Unlock instant, AI-driven research and patent intelligence for your innovation.

Medicinal preparation rehmannia powder with effect of improving animal immunity

A technology for pharmaceutical preparations and animal immunization, which is applied to the field of pharmaceutical preparations Rehmannia glutinosa powder and its preparation, can solve the problems of limited administration routes, poor palatability of powders, low bioavailability, etc., and achieves easy absorption, stable powder properties, and avoidance of mixing materials. effect of the process

Active Publication Date: 2016-11-23
河北正合生物制药有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Powder is a traditional dosage form with a simple production process, but its own defects have seriously hindered its clinical application. For animals that cannot fully digest cellulose, powder has poor palatability and low bioavailability, and it cannot be used in large-scale intensive feeding conditions. However, the route of drug administration to industrial animals, especially pigs and chickens, is subject to multiple restrictions; and traditional mixtures have shortcomings such as poor stability and inconvenient transportation, which also limit their clinical application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal preparation rehmannia powder with effect of improving animal immunity
  • Medicinal preparation rehmannia powder with effect of improving animal immunity
  • Medicinal preparation rehmannia powder with effect of improving animal immunity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A kind of medicinal preparation Rehmannia glutinosa powder with improving animal immune function, its preparation method is as follows:

[0042] Take 1 kg of raw rehmannia root, add 10 kg of water, soak for 1.5 hours, then decoct for 1.5 hours at 80°C under vacuum (-0.02~-0.04MPa), then reflux extraction at 80°C under normal pressure for 3 hours, and then reduce pressure (-0.04MPa) 0.02~-0.04MPa) concentrated to a clear paste with a solid-liquid ratio of 1:1.5 (the relative density of the solid liquid at 60°C is 1.12), and finally in the condition that the inlet air temperature is 145°C and the outlet air temperature is 85°C Carry out spray drying, obtain the rehmannia glutinosa powder of the present invention.

[0043] 150L of clear paste is spray-dried every 3.5 hours. Approximately 43L of clear paste is spray dried per hour.

Embodiment 2

[0045] A kind of medicinal preparation Rehmannia glutinosa powder with improving animal immune function, its preparation method is as follows:

[0046] Take 1kg of raw rehmannia root, add 8kg of water, soak for 1h, then decoct for 2h under vacuum (-0.02~-0.04MPa) at 80°C, then reflux extraction at 80°C under normal pressure for 2h, and then reduce pressure (-0.02~0.04MPa). -0.04MPa) concentrated to a clear paste with a solid-to-liquid ratio of 1:1 (the relative density of the solid-liquid at 60°C is 1.15), and finally sprayed under the condition that the inlet air temperature is 145°C and the outlet air temperature is 85°C Dried to get the rehmannia glutinosa powder of the present invention.

[0047] 150L of clear paste is spray-dried every 3.5 hours. Approximately 43L of clear paste is spray dried per hour.

Embodiment 3

[0049] A kind of medicinal preparation Rehmannia glutinosa powder with improving animal immune function, its preparation method is as follows:

[0050] Take 1 kg of raw rehmannia root, add 12 kg of water, soak for 2 hours, then decoct for 2 hours at 80°C under vacuum (-0.02~-0.04MPa), then reflux at normal pressure at 80°C for 4 hours, and then reduce pressure (-0.02~0.04MPa). -0.04MPa) concentrated to a clear paste with a solid-to-liquid ratio of 1:2 (the relative density of the solid-liquid at 60°C is 1.09), and finally sprayed under the condition that the inlet air temperature is 145°C and the outlet air temperature is 85°C Dried to get the rehmannia glutinosa powder of the present invention.

[0051] 150L of clear paste is spray-dried every 3.5 hours. Approximately 43L of clear paste is spray dried per hour.

[0052] After the trial production of Rehmannia glutinosa powder was completed, we took a pilot product with stable quality and carried out clinical trials with chi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses medicinal preparation rehmannia powder with an effect of improving animal immunity. The rehmannia powder is prepared by the following steps: soaking a raw rehmannia medicinal material for 1-2 hours with 8-12 times weight of water; decocting in vacuum at 75-85 DEG C for 1-2 hours; refluxing and extracting for 1-4 hours at normal pressure and 55-105 DEG C, and concentrating at reduced pressure to obtain clear extract with a material-liquid ratio is 1:1-2; and performing spray drying at an air inlet temperature of 140-150 DEG C and an air outlet temperature of 80-90 DEG C to obtain the rehmannia powder. According to the medicinal preparation rehmannia powder with an effect of improving animal immunity, the traditional Chinese medicinal material raw rehmannia is extracted with water and concentrated to prepare the clear extract with proper density, and is subjected to spray drying to obtain the powder. The preparation process is advanced, water-soluble effective ingredient of the rehmannia is furthest maintained by adopting the water extraction process, and the powder is prepared by spray drying. The medicinal preparation rehmannia powder is convenient to store, transport and clinically apply.

Description

technical field [0001] The invention relates to a veterinary drug preparation, in particular to a medicinal preparation rehmannia powder capable of improving animal immune function and a preparation method thereof. Background technique [0002] In recent years, food safety incidents have occurred frequently, from Sudan red duck eggs in 2006 to melamine milk powder in 2008, to clenbuterol in 2011, and then to the fast-growing chicken and medicinal chicken incidents. Refers to the animal husbandry industry. The country has also attached unprecedented importance to food safety, and the use of certain antibiotics and antiviral drugs is expressly prohibited in the animal husbandry industry. On the other hand, with the rapid development of the livestock and poultry breeding industry, the epidemics of pigs and chickens have become more and more complicated. Infectious diseases show atypical or variable manifestations. Animals after immunization still suffer from the disease due to ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P37/04
CPCA61K36/804A61K2236/331A61K2236/51
Inventor 刘佳刘建伟郭莉武现军张春朴张艳菲刘翠玲董玉青
Owner 河北正合生物制药有限公司