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Pharmaceutical composition and its use

A composition and drug technology, applied in the field of medicine, can solve the problems of limited osteoporosis treatment and unsatisfactory effect, and achieve the effects of improving fatigue, reducing fractures, and reducing the incidence rate

Active Publication Date: 2019-05-14
BEIJING JISHUITAN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment for osteoporosis is quite limited and the effect is not satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The dosage form of the Chinese medicine composition of the present invention is prepared by a conventional preparation method, for example, the preparation process recorded in Fan Biting's "Chinese Medicine Pharmaceutics" (Shanghai Science Press, December 1997, 1st edition), to make a pharmaceutically acceptable conventional dosage form.

[0037] In the application of the present invention, the dosage form of the medicine is selected from one of decoction, tablet, granule, syrup, capsule and oral liquid. In order to realize the above dosage form, it is necessary to add pharmaceutically acceptable adjuvants when preparing these dosage forms, For example: fillers, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, preservatives, bases, etc. Fillers include: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc.; disintegrants include: starch, pregelatinized starch, microcrystalline cellulose, so...

Embodiment 1

[0040] Composition of raw materials: Chuan Duan 10g, Fried Eucommia 10g, Chuan Achyranthes bidentata 20g, Psoralen 10g, Tuyuan 6g, Amomum 6g, Asarum 3g, Guizhi 15g, Clematis 10g, Raw keel 20g, Raw oyster 20g Mother-of-pearl 10g, honeysuckle vine 20g, Qingfeng vine 15g, sarcophagus 10g, frankincense 6g, myrrh 6g, cornus 15g, alisma 10g and centipede 2

[0041] Preparation method: add 600 ml of water to decoct the above raw materials, decoct with strong fire until boiling, continue to decoct with slow fire for 20 minutes, filter, and take 200 ml of juice. Add 500 ml of water, repeat the decoction once for 20 minutes, filter, take 200 ml of juice, combine the two decoctions, mix well, and get a total of 400 ml to obtain a decoction, which is taken warmly twice in the morning and evening.

Embodiment 2

[0043] In 1994, WHO suggested grading and diagnosing osteoporosis based on BMD or BMC (bone mineral content): normal is BMD or BMC within 1 standard deviation (SD) of the mean bone density of normal adults; osteopenia is BMD or BMC decreased by 1-2.5 standard deviations compared with the average bone density of normal adults; osteoporosis was defined as BMD or BMC decreased by more than 2.5 standard deviations compared with the average bone density of normal adults; severe osteoporosis was defined as BMD or BMC decreased by more than 2.5 standard deviations The average bone density of normal adults is reduced by more than 2.5 standard deviations and accompanied by 1 or more fragility fractures. In this diagnostic standard, BMD or BMC can be measured in axial bone or peripheral bone.

[0044] Select 30 patients whose T value is in the range of <2.5, and randomly divide 30 patients with osteoporosis into control group 1 and Gu Yijian two groups, with 15 people in each group, and...

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Abstract

The invention discloses pharmaceutical compositions and uses thereof. Among them, the pharmaceutical composition is made from the following raw materials by weight: 8-12 parts by weight of Chuan Duan, 8-12 parts by weight of Fried Eucommia ulmoides, 16-24 parts by weight of Achyranthes bidentata, and 8-12 parts by weight of Psoralen Parts by weight, Tuyuan 5-7 parts by weight, Amomum villosum 5-7 parts by weight, Asarum 2-4 parts by weight, Guizhi 13-17 parts by weight, Clematis 8-12 parts by weight, Raw dragon bone 16-24 parts by weight 16-24 parts by weight of raw oysters, 8-12 parts by weight of mother-of-pearl, 16-24 parts by weight of honeysuckle, 13-17 parts by weight of green wind vine, 8-12 parts by weight of osmanthus, 5-7 parts by weight of frankincense , 5-7 parts by weight of powdered medicine, 13-17 parts by weight of cornus, 8-12 parts by weight of Alisma and 1-3 parts of centipede. The pharmaceutical composition can not only treat osteoporosis, but also improve patients' symptoms such as fatigue, pain, and difficulty walking, and significantly reduce the incidence of fractures in patients. At the same time, compared with existing drugs for treating osteoporosis, the toxic and side effects are significantly reduced.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition and its application, more specifically to the pharmaceutical composition and the application of the pharmaceutical composition in the preparation of medicines for treating osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic bone disease characterized by low bone mass, destruction of bone microarchitecture, increased bone fragility, and susceptibility to fracture. According to the third American Health and Nutrition Survey data, more than 9.9 million Americans suffer from osteoporosis, and about 43.1 million Americans suffer from osteopenia. One in two white women and one in five men will suffer from an osteoporotic fracture in their lifetime. With the extension of human life span and the arrival of aging society, osteoporosis has become a global health problem, and China is no exception. According to the epidemiological survey...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P19/10A61K35/64A61K35/02A61K35/618A61K35/648A61K35/646
CPCA61K36/8964A61K36/9064A61K35/02A61K35/618A61K35/63A61K35/646A61K35/648A61K36/00A61K36/11A61K36/185A61K36/21A61K36/232A61K36/268A61K36/284A61K36/324A61K36/328A61K36/355A61K36/40A61K36/46A61K36/47A61K36/481A61K36/487A61K36/54A61K36/59A61K36/716A61K36/725A61K36/815A61K36/884A61K2300/00
Inventor 孙成栋田伟
Owner BEIJING JISHUITAN HOSPITAL
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