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Degradable macromolecule network and calcium phosphate bone cement composite bone repair material and preparation method and application thereof

A technology of calcium phosphate bone cement and polymer network, which is applied in additive processing, medical science, prosthesis, etc., to achieve good mechanical properties and biological properties, increase specific surface area, and good designability

Active Publication Date: 2016-12-07
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Degradable macromolecule network and calcium phosphate bone cement composite bone repair material and preparation method and application thereof
  • Degradable macromolecule network and calcium phosphate bone cement composite bone repair material and preparation method and application thereof
  • Degradable macromolecule network and calcium phosphate bone cement composite bone repair material and preparation method and application thereof

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Embodiment 1

[0052] The "partially crystalline calcium phosphate-anhydrous calcium hydrogen phosphate" system bone cement was selected and prepared by 3D printing with a molecular weight of 30kDa and a monomer ratio of PLA:PGA=50:50. PLGA with terminal-COOH could form a three-dimensional connected porous structure network in situ. Equipped with an appropriate device, the calcium phosphate bone cement slurry is poured into the PLGA porous network to prepare a degradable polymer network / calcium phosphate bone cement composite bone repair material. The implementation steps include:

[0053] (1) Use Magics software to design a cylinder model with a diameter of 8 mm and a height of 12 mm, save it as a .stl file, import the .stl file into the Bioplotter RP layering software to layer the cuboid model, and save it as a .bpl file. Weigh 2g of PLGA particles with a molecular weight of 30kDa, monomer ratio PLA:PGA=50:50, and end-COOH, and put them into a stainless steel barrel with a stainless steel f...

Embodiment 2

[0064] The "calcium dihydrogen phosphate + α-tricalcium phosphate + calcium carbonate" system bone cement was selected and prepared by 3D printing with a molecular weight of 110kDa and a monomer ratio of PLA:PGA=50:50. The PLGA with terminal-COOH can form three-dimensional connected pores in situ structured network. Equipped with an appropriate device, the bone cement slurry is poured into the PLGA porous network to prepare a degradable polymer network / calcium phosphate bone cement composite bone repair material. The implementation steps include:

[0065] (1) Use the Magics modeling software to design a cylinder model with a diameter of 8mm and a height of 12mm, save it as a .stl format file, import the .stl file into the BioplotterRP layering software to layer the cuboid model, and save it as a .bpl format document. Weigh 2g of PLGA with a molecular weight of 110kDa, monomer ratio PLA:PGA=50:50, and end-COOH, and put it into a stainless steel barrel with a stainless steel fu...

Embodiment 3

[0075] The "amorphous calcium phosphate + calcium hydrogen phosphate dihydrate" system bone cement was selected, and the molecular weight was 30kDa prepared by 3D printing, the monomer ratio PLA:PGA=75:25, and the PLGA with terminal-COOH could form a three-dimensional connected porous structure network in situ. Equipped with an appropriate device, the bone cement slurry is poured into the PLGA porous network to prepare a degradable polymer network / calcium phosphate bone cement composite bone repair material. The implementation steps include:

[0076] (1) Use the Magics modeling software to design a cylinder model with a diameter of 8mm and a height of 12mm, save it as a .stl format file, import the .stl file into the BioplotterRP layering software to layer the cuboid model, and save it as a .bpl format document. Weigh 2g of PLGA with a molecular weight of 30kDa, monomer ratio PLA:PGA=75:25, and end-COOH, and put it into a stainless steel barrel with a stainless steel funnel. T...

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Abstract

The invention belongs to the technical field of medical materials, and discloses a composite bone repair material of a degradable macromolecule network which can in situ form a three-dimensional interpenetrating porous structure and calcium phosphate bone cement and a preparation method and application of the bone repair material. According to the preparation method, a macromolecule network structure is obtained through printing by means of a 3D printing technology, CPC slurry is injected into the macromolecule network structure, and the repair material is obtained. The degradable macromolecule network which can in situ form the three-dimensional interpenetrating porous structure is printed out through 3D printing, the characteristics, size and porosity of in-situ pore forming are optimized, and the material has a good mechanical property; the macromolecule network is degraded in CPC to in situ form three-dimensional interpenetrating large holes beneficial for bone tissue and blood vessel ingrowth, and therefore new bone tissue and new blood vessels can grow into the CPC; meanwhile, the specific surface area of the CPC is increased, degradation of the CPC is promoted, and therefore the degradability and osteogenesis and blood vessel generation capabilities of the CPC are effectively improved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and particularly relates to a degradable polymer network / calcium phosphate bone cement composite bone repair material capable of forming a three-dimensional interconnected porous structure in situ, a preparation method and application thereof. Background technique [0002] Calcium phosphate cement (CPC) is a new type of bone defect repair material, which has excellent biocompatibility, bioactivity and osteoconductivity, and can be shaped arbitrarily, and can self-cure and Degradable absorption. Through the hydration reaction, CPC finally forms hydroxyapatite (hydroxyapatite, HA), which has the same inorganic composition as human bone tissue, and has excellent biocompatibility. In 1991, CPC was approved by the US Food and Drug Administration (FDA) for clinical use. As a calcium phosphate bone repair material, calcium phosphate bone cement has the following advantages compared with sint...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/58B33Y70/00
Inventor 叶建东钱国文
Owner SOUTH CHINA UNIV OF TECH
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