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Drug composition of cefoperazone

A technology of cefoperazone and composition, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems that have not been reported related to cefoperazone periodontitis, etc., and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-12-07
朱正直
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] So far, there has been no report on the correlation between cefoperazone and its pharmaceutical composition and the treatment of periodontitis

Method used

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  • Drug composition of cefoperazone
  • Drug composition of cefoperazone
  • Drug composition of cefoperazone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Separation, preparation and structure confirmation of compound (I)

[0017] Sources of reagents: Ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd.; methanol, analytically pure, was purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0018] Separation method: (a) pulverize the lotus leaf (2kg), extract with 85% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate to no alcohol odor (3L), and use petroleum ether (3L×3 times) in turn ), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) extraction to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) ) in the ethyl acetate extract was removed with D101 macroporous resin, first eluted with 30% ethanol for 6 column volumes, and then eluted with 85% ethanol for 12 column volumes, collected the 85% eluate, and ...

Embodiment 2

[0022] Example 2: Pharmacological effects

[0023] In this example, a rat model of periodontitis was prepared by cutting and peeling the rat gingiva and feeding white granulated sugar, and the anti-periodontitis effect of the drug in improving the gingival swelling, ulcer and atrophy of the animal was observed.

[0024] 1. Materials and methods

[0025] 1.1 Animals

[0026] Five-week-old SD rats with complete dentition, no caries and periodontal disease, half male and half male, weighing 200±20 g, were selected and provided by Hubei Laboratory Animal Research Center.

[0027] 1.2 Reagents and samples

[0028] Cefoperazone was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, see Example 1 for the preparation method. White granulated sugar, made into 10% sugar water as drinking water, conventional feed, and soaked in this sugar water to make soft feed when feeding. Koutai (Compound Chlorhexidine Gargle), Shen...

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Abstract

The invention discloses a drug composition of cefoperazone and medical application of the drug composition. The drug composition contains cefoperazone and a natural product compound (I) which is novel in structure, and when acting independently, either cefoperazone or the compound (I) has treatmenteffect on periodontitis; when cefoperazone and the compound (I) act jointly, treatment effect is further improved, and the drug composition can be developed into drugs for treating periodontitis. Compared with the prior art, the drug composition has outstanding substantial advantages and remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new use of cefoperazone, in particular to a pharmaceutical composition of cefoperazone and its application in treating periodontitis. Background technique [0002] Cefoperazone is used for the treatment of various infections caused by sensitive enzyme-producing bacteria, such as the treatment of respiratory system, genitourinary system, biliary tract, gastrointestinal tract, chest and abdomen, skin and soft tissue infections, and the treatment of infections caused by influenza bacillus and meningococcus. Intracerebral infection also has better curative effect. [0003] So far, there is no report on the correlation of cefoperazone and its pharmaceutical composition with the treatment of periodontitis. SUMMARY OF THE INVENTION [0004] The object of the present invention is to provide a pharmaceutical composition of cefoperazone, which contains cefoperazone and a natural product, and t...

Claims

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Application Information

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IPC IPC(8): C07C69/78A61K31/546A61K31/235A61P1/02
CPCC07C69/78A61K31/235A61K31/546A61K36/29A61K2300/00
Inventor 朱正直
Owner 朱正直
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