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Hemicellulose-based light response nano hydrogel and preparation method and application thereof

A nano-hydrogel and hemicellulose technology is applied in the field of hemicellulose-based light-responsive nano-hydrogel and its preparation, which can solve the problems of long response time, unenvironmental protection, non-compliance, etc., and achieves good application prospects, biological Good compatibility and high photoresponse efficiency

Active Publication Date: 2016-12-07
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many light-responsive hydrogels reported so far, but these hydrogels have more or less certain deficiencies, and the common performance is that the biocompatibility is not good enough, and they cannot be suitable for organisms and used for biological drug loading. ; The response time is long, and it cannot respond to the light stimulus accurately and timely; the raw material is a synthetic polymer, which is not environmentally friendly and does not conform to the current research concept of green chemistry

Method used

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  • Hemicellulose-based light response nano hydrogel and preparation method and application thereof
  • Hemicellulose-based light response nano hydrogel and preparation method and application thereof
  • Hemicellulose-based light response nano hydrogel and preparation method and application thereof

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Effect test

Embodiment 1

[0030] (1) Into the three-necked flask, pass nitrogen gas, put 40g 1,6-dibromohexane, 12g K 2 CO 3 Add 0.5g KI and 0.5g KI into 125ml acetone, stir well and then slowly heat up to above 60°C; dissolve 4.95g 4-hydroxyazobenzene in acetone, add dropwise to the above reaction system with a constant pressure funnel, drop After adding, it was heated to reflux for 24h. Filter while hot to remove the inorganic salt (filter residue) in the system, wash with acetone and collect the filtrate, evaporate and concentrate the filtrate with a rotary evaporator, add dropwise to cold ethanol to precipitate, filter, and finally recrystallize the solid after drying to obtain yellow flakes The solid is the desired 4-omega-bromohexyloxyazobenzene.

[0031] (2) Under heating conditions, dissolve 1 g of hemicellulose in anhydrous DMSO until completely dissolved into a light yellow transparent solution, then cool down to room temperature, and pass through N 2 Then add 100 μL of 10% alkali solution...

Embodiment 2

[0034] (1) Into the three-necked flask, feed nitrogen, put 15g 1,6-dibromohexane, 4.5g K 2 CO 3 Add 0.2g KI and 0.2g KI into 125mL acetone, stir well and then slowly heat up to above 60°C; dissolve 4.95g 4-hydroxyazobenzene in acetone, and add dropwise to the above reaction system with a constant pressure funnel, dropwise After adding, it was heated to reflux for 24h. Filter while hot to remove the inorganic salt (filter residue) in the system, wash with acetone and collect the filtrate, evaporate and concentrate the filtrate with a rotary evaporator, add dropwise to cold ethanol to precipitate, filter, and finally recrystallize the solid after drying to obtain yellow flakes The solid is the desired 4-omega-bromohexyloxyazobenzene.

[0035] (2) Under heating conditions, dissolve 1 g of hemicellulose in anhydrous DMSO until completely dissolved into a light yellow transparent solution, then cool down to room temperature, and pass through N 2 Then add 100 μL alkali solution w...

Embodiment 3

[0038] (1) Into the three-necked flask, feed nitrogen, mix 40g 1,6-dibromohexane, 12.1g K 2 CO 3 Add 0.5g KI and 0.5g KI into 125ml acetone, stir well and then slowly heat up to above 60°C; dissolve 4.95g 4-hydroxyazobenzene in acetone, add dropwise to the above reaction system with a constant pressure funnel, drop After adding, it was heated to reflux for 24h. Filter while hot to remove the inorganic salt (filter residue) in the system, wash with acetone and collect the filtrate, evaporate and concentrate the filtrate with a rotary evaporator, add dropwise to cold ethanol to precipitate, filter, and finally recrystallize the solid after drying to obtain yellow flakes The solid is the desired 4-omega-bromohexyloxyazobenzene.

[0039] (2) Under heating conditions, dissolve 1 g of hemicellulose in anhydrous DMSO until completely dissolved into a light yellow transparent solution, then cool down to room temperature, and pass through N 2 Then add 100 μL alkali solution with a m...

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Abstract

The invention belongs to the technical field of gel materials and discloses hemicellulose-based light response nano hydrogel and a preparation method and application thereof. The preparation method comprises: reacting 1,6-dibromohexane and 4-hydroxyazobenzene to obtain 4-Omega-bromohexyloxyazobenzene; reacting the 4-Omega-bromohexyloxyazobenzene with hemicellulose to obtain amphiphilic hemicellulose derivative with azobenzene side chains, dissolving the derivative in anhydrous DMSO (dimethylsulfoxide), transferring to a dialysis bag, and dialyzing with distilled water for at least 24 h to obtain the hemicellulose-based light response nano hydrogel. The azobenzene is grafted to hemicellulose molecular chains by means of grafting copolymerization, and the hemicellulose-based light response nano hydrogel is further prepared under hydrophobic association of the side chains; the hydrogel has higher light responding efficiency and good biocompatibility, is better adaptable to human body environment, and has a promising application prospect in terms of targeted slow release therapy for local body lesions after supporting a drug.

Description

technical field [0001] The invention belongs to the technical field of gel materials, and in particular relates to a hemicellulose-based light-responsive nano hydrogel and its preparation method and application. Background technique [0002] With the increasing energy problems, how to make more effective and full use of green energy such as biomass to solve the increasing resource and environmental problems has received widespread attention from the society. [0003] As one of the most widely existing resources in nature, hemicellulose is a renewable, green and environmentally friendly natural polymer material. Due to its complex composition, high degree of branching, low degree of polymerization, and amorphous structure, the theoretical research and practical application of hemicellulose are not as extensive as cellulose and lignin. In the paper industry, hemicellulose and lignin are usually dissolved in the cooking liquor during the cooking stage, and are directly burned ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/14C08B37/14A61K47/36A61K9/06A61K41/00
CPCA61K41/0057A61K47/36A61K9/06C08B37/14C08J3/075C08J2305/14
Inventor 彭新文向志华钟林新
Owner SOUTH CHINA UNIV OF TECH
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