Sugar-containing amphiphilic segmented copolymer and preparation method thereof

A technology of amphiphilic block and copolymer, which is applied in the field of synthesis and preparation of polymer materials, can solve the problems of cumbersome steps of unsaturated sugar-containing monomers, achieve simple polymer grafting means, eliminate synthesis steps and reaction conditions mild effect
CN106336501AActive Publication Date: 2017-01-18SOUTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHWEST UNIV
Publication Date
2017-01-18

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Abstract

The invention discloses a sugar-containing amphiphilic segmented copolymer and also discloses a preparation method of the sugar-containing amphiphilic segmented copolymer. The preparation method specifically comprises the following steps: firstly, a macromolecular chain transfer agent is prepared by a ring opening polymerization method; then, by a reversible addition-fragmentation chain transfer polymerization method and under the action of the macromolecular chain transfer agent, active monomer unsaturated pentafluorophenyl ester polymerization is initiated to prepare an amphiphilic segmented copolymer; and finally, by an active pentafluorophenyl ester-amino reaction method, the segmented copolymer and a sugar-containing polymer containing an amino group react to generate the sugar-containing amphiphilic segmented copolymer. According to the method, the defect that traditional sugar-containing polymer synthesis has complicated steps for preparation of an unsaturated sugar-containing monomer is overcome; reaction steps of the method are simplified; reaction conditions are mild; and the type of a sugar-containing polymer containing an amino group can be selected. The sugar-containing amphiphilic segmented copolymer of the invention has potential application in the aspects of controlled release of drugs and targeting therapy of tumor.
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Description

technical field

[0001] The invention belongs to the technical field of polymer material synthesis and preparation, and relates to an amphiphilic sugar-containing block copolymer and a preparation method thereof. Background technique

[0002] Glycopolymers refer to polymer materials formed by introducing sugar components into polymer molecular chains through different chemical methods. The sugar components can be various monosaccharides (glucose, galactose, mannose), disaccharides (lactose, maltose) and oligosaccharides (maltoheptaose) (Chem.Rev.2016,116,1673-1692; Prog.Polym .Sci.2016,57,64-102). Sugars are widely distributed in living organisms and play a very important role in the activities of living organisms such as immune response, cell growth, embryo formation and intercellular information transmission. Glycopolymers inherit some of the properties of sugar molecules, and have the characteristics of hydrophilicity, biocompatibility, signal transmission, and pathogen ...

Claims

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