Process for manufacturing alpha-tricalcium phosphate-alpha-calcium sulfate hemihydrates bone cement porous bracket through squashing method

A technology of calcium sulfate hemihydrate and tricalcium phosphate, which is applied in the fields of medical science, tissue regeneration, prosthesis, etc., can solve the problems of low uniformity of porosity, inability to mass production, complicated steps, etc., and is suitable for mass production, Reduce the effect of simple preparation and preparation method

Inactive Publication Date: 2017-02-15
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional salting-out method has complicated steps. When forming pores, the powder is usually mixed with the porogen, then solidified liquid is added to shape it, and then the porogen is leached out. The process is slow and the uniformity of pore formation is not high, so it cannot be mass-produced

Method used

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  • Process for manufacturing alpha-tricalcium phosphate-alpha-calcium sulfate hemihydrates bone cement porous bracket through squashing method
  • Process for manufacturing alpha-tricalcium phosphate-alpha-calcium sulfate hemihydrates bone cement porous bracket through squashing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Preparation of α-TCP powder:

[0028] Weigh the calcium hydrogen phosphate powder and the calcium carbonate powder according to the molar ratio of 2:1, use an appropriate amount of absolute ethanol as the medium for wet ball milling, the rotation speed is 400rpm, the ball milling time is 4h, and the mass ratio of ball milling beads to powder is 3:1. The raw material mixture was removed from ethanol by rotary evaporation, and dried in an oven at 60 °C for 24 h. The dried powder is placed in a muffle furnace, calcined at 1400°C for 2 hours, taken out, and rapidly cooled in a blast environment. The cooled powder was wet ball milled with anhydrous ethanol as the medium, the rotation speed was 400 rpm, the ball milling time was 6 h, and the mass ratio of ball milling beads to powder was 4:1. The powder suspension was fully dried in an oven at 80° C. to prepare α-TCP powder.

[0029] (2) Preparation of α-CSH:

[0030] Put 50g of calcium sulfate dihydrate in 150mL of di...

Embodiment 2

[0032] Mix the α-TCP and α-CSH powders prepared in Example 1 at a mass ratio of 7:3, and then mix them with salt particles with a particle size of 100-300 μm at a mass ratio of 5:5 to obtain a bone cement powder, which is placed in A cylindrical mold with a diameter of 6 mm was fully compacted with a tablet press, and after demoulding, it was soaked in a water bath at 37°C for 24 hours to remove salt particles, and a bone cement porous scaffold was obtained. The results of the SEM scanning electron microscope are as follows: figure 1 , figure 2 As shown, the measured porosity is 46%, and the compressive strength is 10MPa.

Embodiment 3

[0034] Mix the α-TCP and α-CSH powders prepared in Example 1 at a mass ratio of 7:3, and then mix them with salt particles with a particle size of 100-300 μm at a mass ratio of 3:7 to obtain a bone cement powder, which is placed in A cylindrical mold with a diameter of 6 mm was fully compacted with a tablet press, and after demoulding, it was soaked in a water bath at 37°C for 24 hours to remove salt particles, and a bone cement porous scaffold was obtained. The measured porosity is 83%, and the compressive strength is 5MPa.

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Abstract

The invention relates to a process for manufacturing an alpha-tricalcium phosphate-alpha-calcium sulfate hemihydrates bone cement porous bracket through a squashing method. The process comprises the following steps: mixing raw materials calcium hydrophosphate and calcium carbonate in molar ratio through a solid-solid reaction process, roasting the raw materials at a temperature ranging from 1250 DEG C to 1400 DEG C, and quickly cooling the raw materials to the room temperature, preparing alpha-TCP powder; putting calcium sulphate dehydrate into distilled water, adding sodium citrate and magnesium sulfate, heating reactants in certain proportion in a sealed container to 130 DEG C, reacting for 6 hours, filtering and drying to prepare alpha-CSH powder; and mixing alpha-TCP and alpha-CSH powder in a mass ratio from (9 to 1) to (5 to 5), taking soluble salt particles or sugar particles with particle diameter being 100 to 300mu m as a pore-foaming agent, sufficiently mixing powder, pressing and forming by use of a tablet press through a proper mould, soaking in 37DEG C water bath, removing the pore-foaming agent during curing, thereby preparing the bone cement porous bracket. According to the process, adopted raw materials are simple and the preparation process is easy, so that the process is suitable for large-scale production.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a method for preparing a porous bone cement scaffold composed of α-TCP [α-tricalcium phosphate] and α-CSH [α-calcium sulfate hemihydrate]. α-TCP, α-CSH powder and an appropriate proportion of filling porogens such as soluble salt, sugar granules, the above-mentioned powders are pressed into a suitable mold with a tablet machine and then directly placed in water to solidify, and the porogens are dissolved at the same time. A bone cement porous scaffold composited with α-TCP and α-CSH was prepared. Background technique [0002] Calcium phosphate bone cement has been widely used in the field of artificial bone repair materials due to its good biocompatibility and osteoinductivity. In the process of repairing bone damage, calcium phosphate bone cement has certain biodegradability in the living body, and the calcium and phosphorus elements released by materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/50A61L27/56
CPCA61L27/12A61L27/025A61L27/50A61L27/56A61L2430/02
Inventor 何丹农杨迪诚严一楠祝闪闪刘训伟金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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