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Triblock copolymer with high biocompatibility and preparation method and application thereof

A biocompatible, tri-block technology, applied in applications, medical science, sensors, etc., can solve problems such as poor controllability of permeation and diffusion, poor water and heat resistance, unfavorable production and long-term storage, and achieve difficult-to-film surface properties Change, hydrolysis resistance, good heat resistance, good heat resistance and stability

Inactive Publication Date: 2017-02-15
MICRO TECH MEDICAL HANGZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, such permeable membranes are mostly made of polyethylene glycol, poly(2-hydroxyethyl methacrylate) and other generally recognized high biocompatibility polymers or their mixtures, but most of them are not suitable for permeation and diffusion. Poor controllability and poor water and heat resistance, will be affected by the surrounding environment to produce changes in properties, so it is not conducive to production and long-term storage

Method used

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  • Triblock copolymer with high biocompatibility and preparation method and application thereof
  • Triblock copolymer with high biocompatibility and preparation method and application thereof
  • Triblock copolymer with high biocompatibility and preparation method and application thereof

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preparation example Construction

[0030] The preparation method of the above-mentioned highly biocompatible tri-block copolymer comprises the following steps:

[0031] Step 1. Add highly hydrophilic soft segment materials, rigid and highly hydrophobic hard segment materials, and flexible polymers into organic solvents, and mix them uniformly at 30-45°C; organic solvents include tetrahydrofuran or isobutanol , the volume of the organic solvent and the total mass ratio of the highly hydrophilic soft segment material, the rigid and highly hydrophobic hard segment material, and the flexible polymer are 2-10ml:1g.

[0032] Step 2: Add a catalyst to the mixed solution in Step 1, and add a block chain extender dropwise, raise the temperature to 55-70° C., and react for 12-20 hours; the catalyst includes triethylenediamine or dibutyltin diisooctoate.

[0033] Step 3, add deionized water to the reaction solution in step 2, and react for 12h-18h; the volume of deionized water and the total mass of the soft segment mater...

Embodiment 1

[0037] Raw materials: polyetheramine, number average molecular weight 1000, mass 25g; polycarbonate diol, number average molecular weight 5000, mass 10g; diamino-terminated polydimethylsiloxane, number average molecular weight 5000, mass 15g; tetrahydrofuran, 100ml; diphenylmethane diisocyanate, mass 12g; deionized water 50ml.

[0038] Step 1: Add polyetheramine, polycarbonate diol, and diamino-terminated polydimethylsiloxane into tetrahydrofuran, and mix well at 40°C.

[0039] Step 2: Add triethylenediamine to the mixed solution in Step 1, and add diphenylmethane diisocyanate dropwise, raise the temperature to 65° C., and react for 12 hours.

[0040] Step 3, adding deionized water to the reaction solution in Step 2, and reacting for 12 hours.

[0041]Step 4: After cooling, the reaction product is washed, filtered and dried to obtain the tri-block copolymer.

Embodiment 2

[0043] Raw materials: amino-terminated polyethylene glycol, number average molecular weight 2000, mass 20g; polycarbonate diol, number average molecular weight 2000, mass 15g; polymethyl methacrylate, number average molecular weight 2000, mass 15g Diamino-terminated polydimethylsiloxane, number average molecular weight 8000, quality 15g; tetrahydrofuran, 500ml; 3g diphenylmethane diisocyanate and 9g dicyclohexylmethane diisocyanate; deionized water 500ml.

[0044] Step 1. Add amino-terminated polyethylene glycol, polycarbonate diol, polymethyl methacrylate, and diamino-terminated polydimethylsiloxane into tetrahydrofuran, and mix well at 30°C.

[0045] Step 2: Add triethylenediamine to the mixed solution in Step 1, and add the mixed solution of diphenylmethane diisocyanate and dicyclohexylmethane diisocyanate dropwise, raise the temperature to 55° C., and react for 14 hours.

[0046] Step 3, adding deionized water to the reaction solution in Step 2, and reacting for 18 hours. ...

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Abstract

The invention discloses a triblock copolymer with high biocompatibility. A general formula of the triblock copolymer is A-b-B-b-C, wherein A, B and C are of block structures, B is a block chain extender, A represents a soft segment material with high hydrophily and is a block formed by at least one of polyethylene glycol, polypropylene glycol and polyether amine; B represents a rigid hard segment material with high hydrophobicity and is a block formed by at least one of polycarbonate and polymethyl methacrylate; C represents a flexible polymer and is a block formed by at least one of polydimethylsiloxane and poly(2-hydroxyethyl methacrylate). A permeable membrane prepared from the triblock copolymer has highly-controlled micromolecule permeability, good water resistance and heat resistance, and adjustable hydrophily and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of block copolymers, in particular to a high biocompatibility tri-block copolymer and its preparation method and application. Background technique [0002] Implantable biosensor refers to a sensor device that can be partially or fully implanted into the human body, which can measure the content of target analyte molecules without the need for additional reagents and pre-separation and treatment of body fluids or blood. The advantage of implantable biosensors is that they can continuously measure some important physiological and pathological parameters in the body that change over time, such as blood oxygen, blood sugar, virus antibodies, etc., so as to more directly reflect the physical signs of the measured object due to environmental changes, Changes in physical activity, diet, and medications. Generally speaking, the sensing part of the implanted sensor needs to interact with the analyte in the tissue to...

Claims

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Application Information

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IPC IPC(8): C08G18/76C08G18/75C08G18/73C08G18/62C08G18/61C08G18/44C08G18/48C08G18/50A61B90/00
CPCC08G18/7671A61B2562/02C08G18/4018C08G18/4063C08G18/44C08G18/482C08G18/5021C08G18/5024C08G18/61C08G18/6225C08G18/6229C08G18/724C08G18/73C08G18/758
Inventor 于非
Owner MICRO TECH MEDICAL HANGZHOU CO LTD
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