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Preparation and application of calcium sulphate cement with osteogenic activity and antibacterial property

A technology of osteogenic activity and bone cement, which is applied in the filling and repairing of human bone tissue, and the field of preparation of injectable bone cement, can solve the problems of limited clinical application of calcium sulfate bone cement, poor osteoinductivity, repair failure, etc., and achieve improvement Bioactivity and biocompatibility, low cost, effect of enhancing osteogenic activity

Inactive Publication Date: 2017-03-08
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Calcium sulfate bone cement also has the problem of poor osteoinductivity in application, and it cannot form a close biochemical connection with the surrounding bone tissue in the early stage, which also causes great limitations to the clinical application of calcium sulfate bone cement
In addition, a common complication of bone defect filling and repair surgery is bacterial infection, bacterial adhesion and bacterial film formation at the interface between bone cement and human tissue, which often lead to repair failure

Method used

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  • Preparation and application of calcium sulphate cement with osteogenic activity and antibacterial property
  • Preparation and application of calcium sulphate cement with osteogenic activity and antibacterial property
  • Preparation and application of calcium sulphate cement with osteogenic activity and antibacterial property

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: In this example, silver strontium hydroxyapatite was prepared, and ammonia water was used to adjust the pH of the mixed solution to 9.0.

[0031] (1) configure silver nitrate solution of the same concentration, strontium nitrate solution, calcium nitrate solution and ammonium phosphate solution, and the solution concentration is 0.3mol / L;

[0032] (2) Add 26.5ml of calcium nitrate solution, 6.67ml of strontium nitrate solution, and 0.33ml of silver nitrate solution into 15.9ml of ammonium phosphate solution dropwise in turn, at a rate of 2ml / min, 10ml / min, and 80ml / min, adjusted with ammonia water pH is 9.0, stir for 30min.

[0033] (3) Put the above mixed solution at 150°C for hydrothermal reaction for 6 hours, stop the reaction, wash 5 times with deionized water and absolute ethanol, filter with suction to obtain a white precipitate, dry at constant temperature for 24 hours at 60°C, and grind it into powder Then sinter at 800°C for 2 hours to obtain silver...

Embodiment 2

[0034] Example 2: In this example, silver strontium hydroxyapatite was prepared, and ammonia water was used to adjust the pH of the mixed solution to 9.5.

[0035] (1) Silver nitrate solution of the same concentration, strontium nitrate solution, calcium nitrate solution and sodium phosphate solution are configured, and the solution concentration is 0.3mol / L;

[0036] (2) Add 26.5ml of calcium nitrate solution, 6.67ml of strontium nitrate solution, and 0.33ml of silver nitrate solution into 15.9ml of ammonium phosphate solution dropwise in turn, at a rate of 2ml / min, 10ml / min, and 80ml / min, adjusted with ammonia water The pH was 9.5, stirred for 30min.

[0037] (3) Put the above mixed solution at 150°C for hydrothermal reaction for 6 hours, stop the reaction, wash 5 times with deionized water and absolute ethanol, filter with suction to obtain a white precipitate, dry at constant temperature for 24 hours at 60°C, and grind it into powder Then sinter at 800°C for 2 hours to ob...

Embodiment 3

[0038] Example 3: In this example, silver strontium hydroxyapatite was prepared, and ammonia water was used to adjust the pH of the mixed solution to 10.0.

[0039] (1) Silver nitrate solution of the same concentration, strontium nitrate solution, calcium nitrate solution and sodium phosphate solution are configured, and the solution concentration is 0.3mol / L;

[0040](2) Add 26.5ml of calcium nitrate solution, 6.67ml of strontium nitrate solution, and 0.33ml of silver nitrate solution into 15.9ml of ammonium phosphate solution dropwise in turn, at a rate of 2ml / min, 10ml / min, and 80ml / min, adjusted with ammonia water The pH was 10.0, stirred for 30min.

[0041] (3) Put the above mixed solution at 150°C for hydrothermal reaction for 6 hours, stop the reaction, wash 5 times with deionized water and absolute ethanol, filter with suction to obtain a white precipitate, dry at constant temperature for 24 hours at 60°C, and grind it into powder Then sinter at 800°C for 2 hours to o...

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Abstract

The invention provides preparation and application of calcium sulphate cement with osteogenic activity and antibacterial property. The calcium sulphate cement comprises a solid phase and a liquid phase, wherein the solid phase comprises the following components in percentages by mass: 80-90% of calcium sulphate and 10-20% of silver-strontium hydroxyl apatite; and the liquid phase is 0.1-1wt% of an aqueous solution of O-carboxymethyl chitosan. The solid-phase calcium sulphate is modified by synthesized strontium-silver-doped hydroxyl apatite in a compounded manner, the doped strontium which is a microelement has double effects of inducing osteogenesis and suppressing osteoclast, the silver as an antibacterial agent can be used widely, and owing to addition of the strontium and the silver, the osteoconduction and the antibacterial property of the calcium sulphate cement are improved. In the liquid phase, O-carboxymethyl chitosan molecules contain abundant hydroxyls (-OH) and carboxyls (-COOH), the biological activity and the biological compatibility of the calcium sulphate cement are improved effectively, and the prepared calcium sulphate cement has the advantages of long injectable time, high compressive strength, small degradation rate and the like.

Description

technical field [0001] The invention relates to the preparation of an injectable bone cement with both osteogenic activity and antibacterial properties, which is mainly used for filling and repairing human bone tissue, and belongs to the field of biomedical materials. Background technique [0002] Bone tissue defect is one of the common clinical diseases. Injectable bone repair materials are injected directly into the defect site during surgery. The material can be arbitrarily shaped at the defect site. In recent years, it has been used as a treatment method for bone defect filling and repair. received a lot of attention. Calcium sulfate (CSC) bone cement, as a traditional bone repair material, has the advantages of injectability, degradability, good osteoconductivity, biocompatibility, etc., and calcium sulfate has a wide range of raw materials and low price. A promising bone repair material. However, the performance of pure calcium sulfate bone cement is not very ideal. ...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/46A61L27/44
CPCA61L27/54A61L27/446A61L27/46A61L27/50A61L2300/102A61L2300/104A61L2400/06A61L2430/02C08L5/08
Inventor 贾莉莉李朝阳骆伟杨贤金崔振铎朱胜利梁砚琴吕维加
Owner TIANJIN UNIV
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