An electrospinning collection device and a method for preparing nanofibers with a gradient orientation structure

A collection device and electrospinning technology, applied in fiber processing, fiber chemical characteristics, filament/thread forming, etc., can solve the problems of irregular arrangement of nanofibers, and achieve the effects of easy assembly, simple parts, and excellent mechanical properties

Active Publication Date: 2019-04-09
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, most of the electrospinning collection methods are collected by flat plates or rollers, and most of the obtained fiber mats are in the form of non-woven fabrics, and the arrangement of nanofibers is irregular.

Method used

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  • An electrospinning collection device and a method for preparing nanofibers with a gradient orientation structure
  • An electrospinning collection device and a method for preparing nanofibers with a gradient orientation structure
  • An electrospinning collection device and a method for preparing nanofibers with a gradient orientation structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh 1.2 g of polycaprolactone, add 10 mL of a mixed solution of dichloromethane and N-N dimethylformamide with a volume ratio of 4:1, and stir for 12 hours. Use a 10mL syringe to absorb the above-prepared spinning solution, and connect it to a needle through a polyethylene catheter. The needle is a 20G needle, connected to a 15kV high-voltage positive voltage, and the conical receiving head of the electrospinning receiving device is connected to a 5kV negative voltage. The magnet connecting the receiving head is a cylindrical magnet with a diameter of 5 mm. The electrospinning collection device was placed under the needle with a distance of 18 cm, and the distance between the two receiving heads was 0.5 cm. The flow rate of the spinning solution was 1.0 mL / h, and the total spinning time was 3 h. The prepared scaffolds were vacuum-dried. figure 2 Parallel-oriented sections of polycaprolactone nanofibrous scaffolds are shown. image 3 The randomly oriented sections...

Embodiment 2

[0040] Weigh 0.012 g of carbon nanotubes, add 10 mL of trifluoroethanol solution to disperse evenly, add 1.2 g of polycaprolactone and stir for 12 hours. Use a 10mL syringe to absorb the above-prepared spinning solution, and connect it to a needle through a polyethylene catheter. The needle is a 20G needle, connected to 15kV high voltage positive electricity. The electrospinning collection device was placed under the needle with a distance of 20 cm, and the distance between the two receiving heads was 7 cm. The conical receiving head of the electrospinning receiving device was connected to a negative voltage of 0 kV. The magnet connecting the receiving head is a cylindrical magnet with a diameter of 15mm. The flow rate of the spinning solution was 1.0 mL / h, and the total spinning time was 2 h. The prepared scaffolds were vacuum-dried. The average diameter of the obtained nanofibers is 242 nm, the standard deviation is 49 nm, and the ultimate tensile strength is as high as ...

Embodiment 3

[0042] Weigh 2 g of polylactic acid-glycolic acid copolymer, dissolve in hexafluoroisopropanol, and stir for 24 hours. Use a 10mL syringe to absorb the above-prepared spinning solution, and connect it to a needle through a polyethylene catheter. The needle is 18G needle, connected to 10kV high voltage positive electricity. The electrospinning collection device was placed under the needle with a distance of 10 cm, and the distance between the two receiving heads was 3 cm. The conical receiving head of the electrospinning receiving device was connected to a negative voltage of 3 kV. The magnet connecting the receiving head is a cylindrical magnet with a diameter of 10mm. The flow rate of the spinning solution was 1.0 mL / h, and the total spinning time was 1 h. The prepared scaffolds were vacuum-dried. The obtained nanofibers have good morphology, the average diameter is 352nm, the standard deviation is 72nm, the angle distribution is between -25°~20°, the degree of orientatio...

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Abstract

The invention discloses an electrostatic spinning collecting device and a preparation method of nanofiber adopting a gradient-oriented structure. The electrostatic spinning collecting device consists of a power supply, a forward and reverse rotation controller, motors, magnets and receiving heads. The preparation method comprises the following steps: dissolving a solute such as polycaprolactone into a mixed solution of dichloromethane and N-N dimethylformamide, uniformly stirring, and adjusting the spinning positive voltage to be 10-20 kV, the negative pressure to be -5 kV to 0 kV, the distance between a needle head and the electrostatic spinning collecting device to be 10-20 cm, and the distance between the two conical receiving heads to be 0.5-7 cm. In the spinning process, parallel fibers are deposited between the receiving heads, while the fibers deposited at the receiving heads are randomly oriented, and a transitional area exists in the middle. Through the electrostatic spinning collecting device and the preparation method, a nanofiber stent adopting the gradient-oriented structure can be obtained; the nanofiber stent adopting the gradient-oriented structure has relatively high mechanical strength, simulates an arrangement mode of collagen fibers in a muscle tendon and a ligament tissue, and can be applied to tissue engineering and tissue repair of the muscle tendon and the ligament.

Description

technical field [0001] The invention belongs to the technical field of electrospinning, and in particular relates to an electrospinning collection device and a method for preparing nanofibers with gradient orientation structures. Background technique [0002] Electrospinning is currently a simple method for preparing nanofibers, which has the advantages of wide source of raw materials and simple equipment. Electrospun nanofibers have high porosity and specific surface area, mimic the structure of extracellular matrix, and are widely used in tissue engineering, drug sustained release and other fields. [0003] Electrospinning is to slowly flow out the polymer solution from the needle through the syringe pump, and at the same time bring thousands of volts or even tens of thousands of volts of high-voltage static electricity, the charged droplets form Taylor cones under the action of the electric field force, when the electric field force overcomes the solution When the surfac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D5/00D01F6/62D01F9/12D01F9/08D01F4/00
CPCD01D5/0076D01D5/0092D01F4/00D01F6/625D01F9/08D01F9/12
Inventor 杜昶林子锋赵秀娟
Owner SOUTH CHINA UNIV OF TECH
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