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Cefquinome sulfate injection and preparation process

A technology of cefquinoxime sulfate and injection, which is applied in the field of medicine, can solve the problems of lack of coordination and synergy in treatment effect, inconvenient use, side effects, etc., and achieves the effects of not easy stratification, good acupuncture, and good stability

Inactive Publication Date: 2017-03-15
SICHUAN MEIJIALONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are some technical problems in the traditional dosage form and process, such as easy layering and sedimentation. In the preparation method, because the particles of cefquinome sulfate are large, the grinding time of the homogenizer is long, so in order to control the fineness, the temperature of the liquid is instantly higher, so that The potency of the finished product drops faster, the sedimentation speed is faster, and it is inconvenient to use
Antioxidants are commonly used antioxidants, which have no coordination and synergistic effect on the therapeutic effect, and there are certain side effects

Method used

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  • Cefquinome sulfate injection and preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The cefquinome sulfate injection formula includes the following components in parts by weight: 2.5 parts of cefquinome sulfate, 2.2 parts of aluminum stearate, 1.2 parts of lecithin, 2.2 parts of span, 0.12 parts of phenol, 0.12 parts of vitamin E, oil Ethyl acetate was added to 100 parts.

[0027] The specific preparation process is as follows:

[0028] (1) Ethyl oleate was sterile filtered with a 0.25um microporous membrane.

[0029] (2) the cefquinoxime sulfate ultrafine pulverization of prescription quantity, particle size after pulverization is 5um, joins 10 parts of ethyl oleate again, in the aluminum stearate of prescription quantity, lecithin, Span;

[0030] (3) Add remaining ethyl oleate and the vitamin E homogenizer of prescription quantity and grind to 5um;

[0031] (4) Add phenol and stir evenly.

[0032] (5) Subpackage can be done.

Embodiment 2

[0034] The cefquinome sulfate injection formula includes the following components by weight: 2.5 parts of cefquinome sulfate, 1.8 parts of aluminum stearate, 0.8 parts of lecithin, 1.8 parts of span, 0.08 parts of phenol, 0.08 parts of vitamin E, oil Ethyl acetate was added to 100 parts.

[0035] The specific preparation process is as follows:

[0036] (1) Ethyl oleate was sterile filtered with a 0.25um microporous membrane.

[0037] (2) the cefquinoxime sulfate ultrafine pulverization of prescription quantity, particle size after pulverization is 15um, then joins 10 parts of ethyl oleate, in the aluminum stearate of prescription quantity, lecithin, Span;

[0038] (3) Add remaining ethyl oleate and the vitamin E homogenizer of prescription quantity and grind to 15um;

[0039] (4) Add phenol and stir evenly.

[0040] (5) Subpackage can be done.

Embodiment 3

[0042] The cefquinome sulfate injection formula includes the following components by weight:

[0043] 2.5 parts of cefquinome sulfate, 2 parts of aluminum stearate, 1 part of lecithin, 2 parts of Span, 0.1 part of phenol, 0.1 part of vitamin E, and ethyl oleate to 100 parts.

[0044] The specific preparation process is as follows:

[0045] (1) Ethyl oleate was sterile filtered with a 0.25um microporous membrane.

[0046] (2) the cefquinoxime sulfate ultrafine pulverization of prescription quantity, particle size after pulverization is 10um, then joins 10 parts of ethyl oleate, in the aluminum stearate of prescription quantity, lecithin, Span;

[0047] (3) Add remaining ethyl oleate and the vitamin E homogenizer of prescription quantity and grind to 10um;

[0048] (4) Add phenol and stir evenly.

[0049] (5) Subpackage can be done.

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Abstract

The invention belongs to the field of the animal medicine, and particularly relates to cefquinome sulfate injection and a preparation process. The formula comprises the following components by weight: 2.5 parts of cefquinome sulfate, 1.8-2.2 parts of aluminum stearate, 0.8-1.2 parts of lecithin, 1.8-2.2 parts of span E, 0.08-0.12 parts of phenol, 0.08-0.12 parts of vitamin E, and 100 parts of ethyl oleate. After the cefquinome sulfate is superfine-grinded, the prepared suspension preparation is not easy to layering and settling, the sedimentation rate is reduced above 50%. The preparation is easy to shake uniformly in use, the needle cleaning property is better, the injection is easy, and the stress after the injection is smaller. A specific pure natural antioxidant is added, so the stability is better, and the content descent rate is reduced by 18%.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a cefquinome sulfate injection and a preparation process. Background technique [0002] Cefquinome Sulfate, English name: Cefquinome Sulfate. Chemical name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo -3-(5,6,7,8-tetrahydroquinolin-1-ylmethyl)-5-thio-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid inner salt sulfuric acid Salt. It is off-white or light yellow crystalline powder; content: ≥99%. It is hygroscopic and slightly soluble in water. Mainly used for bacterial infections of cattle, pigs, poultry and other animals, such as Marcellus hemolyticus, Marcellobacter multocida, Salmonella, Escherichia coli, Streptococcus, Staphylococcus aureus, Corynebacterium, Haemophilus somnus Genus, Serratia marcescens, Actinomyces pyogenes, Klebsiella, Proteus, Citrobacter, Clostridium, Actinomyces pneumoniae, Erysipelas suis, etc. [0003] There are some techn...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K47/24A61K47/22A61P31/04
CPCA61K9/0019A61K9/10A61K31/546A61K47/22A61K47/24
Inventor 杨建平
Owner SICHUAN MEIJIALONG BIOTECH
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