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A method of self-assembling nanofibers using small molecular weight sodium alginate

A technology of sodium alginate and small molecular weight, applied in the direction of nanotechnology, alginate artificial filament, etc., can solve the problems of high cost of electrospinning equipment, difficult control of process parameters, and complicated preparation process of spinning solution. Achieve the effects of long-term preservation, simple instruments/equipment, and low preparation cost

Active Publication Date: 2018-07-06
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] It is not difficult to see that the main problems or shortcomings of electrospinning are: First, the preparation process of the spinning solution is complicated and the control of the process parameters is difficult. Correspondingly, the product quality (performance indicators, fiber morphology, etc.) Second, the cost of electrospinning equipment is high and the operating cost is relatively high; third, the diameter of the prepared nanofibers is relatively large, generally above several hundred nanometers

Method used

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  • A method of self-assembling nanofibers using small molecular weight sodium alginate
  • A method of self-assembling nanofibers using small molecular weight sodium alginate

Examples

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Effect test

Embodiment 1

[0044] Preparation methods include as figure 1 Three steps are shown:

[0045] The first step, the preparation of the sodium alginate of small molecular weight:

[0046] Proportionally, high molecular weight sodium alginate (weight average molecular weight is 313kDa) was added into deionized water, swelled and dissolved by stirring to obtain a sodium alginate solution A with a concentration of 1.5% by mass;

[0047] Then, add hydrogen peroxide to obtain a mixed solution, the mass fraction of hydrogen peroxide in the mixed solution is 1.5%;

[0048] Heat the mixed solution to 65°C in a water bath, and stir for 12 hours;

[0049] Then, according to the volume ratio of the mixed solution and absolute ethanol being 1:2, add absolute ethanol to the mixed solution, precipitate and centrifuge to obtain a solid with small molecular weight sodium alginate as the main component;

[0050] The resulting solid was dissolved in deionized water, followed by dialysis and freeze-drying to o...

Embodiment 2

[0056] Preparation methods include as figure 1 Three steps are shown:

[0057] The first step, the preparation of the sodium alginate of small molecular weight:

[0058] In proportion, sodium alginate with a large molecular weight (weight-average molecular weight of 586kDa) was added to deionized water, swelled and dissolved by stirring, to obtain a sodium alginate solution A with a concentration of 1.5% by mass;

[0059] Then, add hydrogen peroxide to obtain a mixed solution, the mass fraction of hydrogen peroxide in the mixed solution is 1.5%;

[0060] Heat the mixed solution to 65°C in a water bath, and stir for 15 hours;

[0061] Then, according to the volume ratio of the mixed solution and absolute ethanol being 1:2, add absolute ethanol to the mixed solution, precipitate and centrifuge to obtain a solid with small molecular weight sodium alginate as the main component;

[0062] The resulting solid was dissolved in deionized water, followed by dialysis and freeze-dryin...

Embodiment 3

[0070] Preparation methods include as figure 1 Three steps are shown:

[0071] The first step, the preparation of the sodium alginate of small molecular weight:

[0072] In proportion, sodium alginate with a large molecular weight (weight-average molecular weight of 425kDa) was added to deionized water, swelled and dissolved by stirring to obtain a sodium alginate solution A with a concentration of 1.5% by mass;

[0073] Then, add hydrogen peroxide to obtain a mixed solution, the mass fraction of hydrogen peroxide in the mixed solution is 1.5%;

[0074] Heat the mixed solution to 65°C in a water bath, and stir for 5 hours;

[0075] Then, according to the volume ratio of the mixed solution and absolute ethanol being 1:2, add absolute ethanol to the mixed solution, precipitate and centrifuge to obtain a solid with small molecular weight sodium alginate as the main component;

[0076] The resulting solid was dissolved in deionized water, followed by dialysis and freeze-drying ...

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Abstract

The invention discloses a method for self-assembling small-molecular-weight sodium alginate into nanofibers. The method includes the following steps that large-molecular-weight sodium alginate is degraded into small-molecular-weight sodium alginate; then deionized water is added to the small-molecular-weight sodium alginate and the small-molecular-weight sodium alginate is dissolved; finally, the sodium alginate solution is still standing, and the sodium alginate nanofibers stored in a solution system are obtained through self-assembly, that is, accordingly self-assembly happens through degradation, solubilization and gathering of molecular chains of the small-molecular-weight sodium alginate, and the sodium alginate nanofibers uniform in dispersity and capable of being used for preparing hydrogel with high strength and good thixotropy are obtained after multi-stage self-assembly. By simply regulating the molecular weight of sodium alginate, no cross-linking agents or electrolyte salt needs to be added, and the nanofibers can be obtained through self-assembly. The preparation method is simple, direct and efficient, and especially the prepared sodium alginate nanofibers are pure sodium alginate components.

Description

technical field [0001] The invention relates to a method for preparing sodium alginate nanofibers, in particular to a method for self-assembling nanofibers using small molecular weight sodium alginate. Background technique [0002] Sodium alginate (Sodium Alginate, SA), also known as sodium alginate, is composed of β-D-mannuronic acid (M segment) and α-L-guluronic acid (G segment) through 1-4 glycosidic bonds Linked natural linear polymers. [0003] Because sodium alginate has good biocompatibility, degradability, strong hygroscopicity and hemostatic properties, it has broad application prospects in drug release and tissue engineering. Among them, the nanofibers made of sodium alginate have high utilization value in the fields of tissue engineering and drug release due to their very high volume-to-surface area ratio. [0004] In the prior art, sodium alginate nanofibers can only be prepared by electrospinning. [0005] Because the molecular chain of sodium alginate is rig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F9/04B82Y40/00
CPCB82Y40/00D01F9/04
Inventor 隋坤艳谭业强张庆旭王丽男赵志唯潘娜
Owner QINGDAO UNIV
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