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American ginseng wall-breaking pellet and preparation method thereof

A technology of American ginseng and pellets, which is applied in the field of American ginseng broken wall pellets and its preparation, can solve the problems of easy peaks and valleys, incomplete stimulation of drug effects, waste of medicinal materials, etc., and achieve masking of bad smell, significant medicinal value, The effect of increasing the dissolution rate

Inactive Publication Date: 2017-04-26
HUNAN ZHONGJIAN XINYUAN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The traditional methods of taking include boiling, stewing, steaming, slicing and melting, grinding into fine powder, etc. However, although these methods can stimulate the efficacy of the medicine, the stimulation of the efficacy of the medicine is not complete, resulting in a waste of medicinal materials, and prone to peaks and valleys phenomenon, affect the actual effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Step 1. Raw material processing: take 5 parts of American ginseng, wash them, remove impurities, and dry them for later use; take 6 parts of carbomer, 5 parts of ethyl cellulose, 3 parts of stearic acid, and 30 parts of microcrystalline cellulose and add them after crushing Nano-scale grinding machine to make powder for later use;

[0046] Step 2, preparation of suspension: take 1000 parts of purified water, add 10 parts of talcum powder, and 20 parts of plasticizer and fully stir to make a coating suspension;

[0047] Step 3, breaking the wall to make powder: take the American ginseng in step 1 and use the low-temperature airflow crushing method to make the American ginseng wall breaking powder, put the material into the powder machine for coarse grinding, and obtain 80 mesh coarse grains; dry the coarse grains at 0 °C, and then Soak the coarse grains in 9% carbonic acid solution and power on for 40 minutes, the power supply voltage is 5V; then dry the coarse grains at...

Embodiment 2

[0051] Step 1. Raw material processing: take 6 parts of American ginseng, wash them, remove impurities, and dry them for later use; take 7 parts of povidone, 5 parts of ethyl cellulose, 4 parts of stearic acid, and 60 parts of microcrystalline cellulose and add them after crushing Nano-scale grinding machine to make powder for later use;

[0052] Step 2, preparation of suspension: take 1000 parts of purified water, add 20 parts of talcum powder, and 30 parts of plasticizer and fully stir to make a coating suspension;

[0053]Step 3, breaking the wall to make powder: take the American ginseng in step 1 and use the low-temperature airflow crushing method to make the American ginseng wall breaking powder, put the material into the powder machine for coarse grinding, and obtain 80 mesh coarse grains; dry the coarse grains at 0 °C, and then Soak the coarse grains in 10% carbonic acid solution and power on for 20 minutes, the power supply voltage is 6V; then dry the coarse grains at...

Embodiment 3

[0057] Step 1. Raw material processing: Take 8 parts of American ginseng, wash them, remove impurities, and dry them for later use; take 6 parts of carbomer, 6 parts of ethyl cellulose, 5 parts of stearic acid, and 90 parts of microcrystalline cellulose and add them after crushing Nano-scale grinding machine to make powder for later use;

[0058] Step 2, preparation of suspension: take 1000 parts of purified water, add 10 parts of talcum powder, and 25 parts of plasticizer and fully stir to make a coating suspension;

[0059] Step 3, breaking the wall to make powder: take the American ginseng in step 1 and use the low-temperature airflow pulverization method to make American ginseng wall-breaking powder, put the material into a powder machine for coarse grinding, and obtain 80-mesh coarse grains; dry the coarse grains at -5°C, Then soak the coarse grains in 11% carbonic acid solution and power on for 10 minutes, and the power supply voltage is 7V; then dry the coarse grains at...

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Abstract

The invention discloses an American ginseng wall-breaking pellet. The American ginseng wall-breaking pellet is prepared from American ginseng wall-breaking powder, carbomer, ethyecellulose, stearic acid, and microcrystalline cellulose. The invention further discloses a preparation method of the American ginseng wall-breaking pellet. The preparation improves the dissolving speed of effective components of the drug and the absorbing effect in the body, largely improves the bioavailability, obtains the ideal drug release rate and prospective blood concentration, avoids peak-valley phenomenon, and maintains a long acting time.

Description

technical field [0001] The invention belongs to a pellet, in particular to an American ginseng wall-broken pellet and a preparation method thereof. Background technique [0002] American ginseng has the dual effects of nourishing yin and nourishing qi, calming the mind and improving intelligence, clearing heat and promoting body fluid, reducing fire and relieving heat. An old saying goes: "American ginseng is cool in nature and nourishing. Anyone who wants to use ginseng without the warmth of ginseng can use it." Therefore, nourishing but not drying is the special feature of American ginseng. American ginseng has many functions: [0003] 1. Strengthen the myocardium and enhance the activity of the heart. [0004] 2. Strengthen the central nervous system, stabilize the body and mind and restore fatigue, have sedative and hangover effects, enhance memory ability, and have a significant effect on Alzheimer's disease. [0005] 3. It can adjust blood pressure, reduce temporar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/38A61K36/258A61P1/14
CPCA61K9/501A61K9/5089A61K36/258A61K47/38
Inventor 夏钊陈仲慧廖雪松
Owner HUNAN ZHONGJIAN XINYUAN BIO TECH
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