Ticagrelor and aspirin compound tablet and preparation method thereof

A technology of aspirin and ticagrelor, which is applied in the directions of drug combination, pill delivery, pharmaceutical formulation, etc., can solve the problems of poor stability, high viscosity, serious sticking of tableting devices, etc., and achieves reduction of stickiness and less generation of impurities. , the effect of prolonging the storage time

Active Publication Date: 2017-05-10
SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the first technical problem to be solved by the present invention is to overcome the defects that the viscosity of ticagrelor and aspirin in the prior art is high and the tableting device sticks seriously during the tablet making process, thereby providing a kind of ticagrelor Composite tablet with

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ticagrelor and aspirin compound tablet and preparation method thereof
  • Ticagrelor and aspirin compound tablet and preparation method thereof
  • Ticagrelor and aspirin compound tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] This embodiment provides a composite tablet of ticagrelor and aspirin, which includes the following raw materials:

[0046] name The first sheet (mg) can be Second sheet (mg) Ticagrelor 90 - aspirin - 75 stearic acid 7.5 15 Micropowder silica gel 1.5 1.5 Mannitol 120 45 corn starch - 75 Low-substituted hydroxypropyl cellulose 9 - hydrogenated castor oil 3 1.5 Magnesium stearate 3 1.5

[0047] The preparation method of the ticagrelor and aspirin composite tablet of the present embodiment comprises the steps:

[0048] (1) According to the amount of raw materials described in the first sheet in the above table, the required ticagrelor, stearic acid, micronized silica gel, mannitol, low-substituted hydroxypropyl cellulose, hydrogenated castor oil and stearin Magnesium acid mixed to prepare the first granules; according to the amount of raw materials described in the second sheet in the above tab...

Embodiment 2

[0051] This embodiment provides a composite tablet of ticagrelor and aspirin, which includes the following raw materials:

[0052] name The first layer can second sheet Ticagrelor 90 - aspirin - 100 stearic acid 10 20 Micropowder silica gel 1.5 1.5 Mannitol 120 45 pregelatinized starch 80 75 Crospovidone 4 - talcum powder 7 3 Magnesium stearate 2 8

[0053] The present embodiment provides a kind of preparation method of ticagrelor and aspirin composite tablet, comprising the following steps:

[0054](1) According to the amount of raw materials described in the first sheet in the above table, mix the required ticagrelor, stearic acid, micropowder silica gel, mannitol and pregelatinized starch, add absolute ethanol and place Granulated in a wet granulator, the obtained granules were dried at 60°C, mixed with crospovidone, talc powder and magnesium stearate, rolled into tablets, and crushed into granu...

Embodiment 3

[0058] This embodiment provides a composite tablet of ticagrelor and aspirin, which includes the following raw materials:

[0059] name The first layer can second sheet Ticagrelor 90 - aspirin - 100 stearic acid 1 4 Micropowder silica gel 1 2 Mannitol 100 50 lactose 50 70 Carboxymethyl Starch Sodium 12 6 polyethylene glycol 6000 - 4 Magnesium stearate 1 1

[0060] The present embodiment provides a kind of preparation method of ticagrelor and aspirin composite tablet, comprising the following steps:

[0061] (1) According to the amount of raw materials described in the first sheet in the above table, mix the required ticagrelor, stearic acid, micronized silica gel, mannitol, lactose, and sodium carboxymethyl starch, and then add stearin Magnesium acid, stirred evenly, and dry granulated to obtain the first granule.

[0062] (2) According to the amount of raw materials described in the second sheet ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Weightaaaaaaaaaa
Login to view more

Abstract

The invention provides a ticagrelor and aspirin compound tablet and a preparation method thereof. The ticagrelor and aspirin compound tablet is prepared from an anti-sticking agent formed by stearic acid and aerosil in a mass ratio of (5-30) to (1-3). The ticagrelor and aspirin compound tablet has high stability, is easy to store, is less in adhesion between the tablet and a tableting device in a tableting process, and has a high tableting success rate.

Description

technical field [0001] The invention relates to a compound tablet of ticagrelor and aspirin and a preparation method thereof, belonging to the technical field of drug synthesis. Background technique [0002] With the change of people's living environment and eating habits, the incidence of cardiovascular and cerebrovascular diseases is increasing year by year. Thrombotic disease belongs to cardiovascular diseases. It is caused by the narrowing and occlusion of the inner cavity of blood vessels caused by thrombus, which leads to ischemia and infarction of major organs. And peripheral vascular disease, with high incidence and high disability, lethal characteristics. The occurrence of thrombotic diseases is related to vascular intima damage, changes in local blood flow, and changes in blood components. For example, after severe trauma, postpartum, and major surgery, platelets and coagulation factors increase, blood coagulation is greatly increased, and blood in the cardiovascul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/20A61K47/12A61K47/04A61K31/519A61K31/616A61P7/02
CPCA61K9/2009A61K9/2013A61K9/209A61K31/519A61K31/616
Inventor 居丽娜王丹梅邓银来陈言德臧建英袁卫东
Owner SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap