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A kind of royal jelly pellet buccal tablet and preparation method thereof

A technology for jelly pellets and royal jelly, which is applied in the field of royal jelly pellet lozenges and their preparation, can solve the problems of incomplete stimulation of drug effects, easy occurrence of peak-valley phenomenon, influence effect, etc., so as to cover bad odor and improve bioavailability. , the effect of convenient use

Active Publication Date: 2019-09-03
HUNAN ZHONGJIAN XINYUAN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And although the traditional taking method can stimulate the efficacy of the medicine, the stimulation of the efficacy of the medicine is not complete, resulting in a waste of medicinal materials, and it is prone to peak and valley phenomena, which affects the actual effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1, raw material processing: take povidone K30, ethyl cellulose, stearic acid, microcrystalline cellulose and pulverize them, add them into nano-grinding machine for powdering for later use;

[0029] Step 2, powder making: take the royal jelly in step 1 and treat it with electricity for 10 minutes, the power supply voltage is 7V, and then the pre-royal jelly is vacuum freeze-dried at low temperature and hydraulically formed into flakes; the flake royal jelly is added to a powder machine for coarse crushing, and then added to an ultra-fine grinder for crushing , to obtain 300 mesh fine particles; the crushed fine particles are added to a low-temperature air flow mill, and 10 parts of 800 mesh royal jelly powder are obtained after crushing; and the air flow crushing is carried out in a vacuum environment, and the vacuum environment is that the vacuum degree is -0.08MPa; The air pressure for crushing is 0.8MPa, and the working temperature is -3°C; the above steps are ca...

Embodiment 2

[0033] Step 1, raw material processing: take povidone K30, ethyl cellulose, stearic acid, microcrystalline cellulose and pulverize them, add them into nano-grinding machine for powdering for later use;

[0034] Step 2, powder making: take the royal jelly in step 1 and treat it with electricity for 10 minutes, the power supply voltage is 7V, and then the pre-royal jelly is vacuum freeze-dried at low temperature and hydraulically formed into flakes; the flake royal jelly is added to a powder machine for coarse crushing, and then added to an ultra-fine grinder for crushing , to get 300 mesh fine particles; the crushed fine particles are added to the low-temperature airflow mill, and 10 parts of 800 mesh royal jelly powder are obtained after crushing; and the airflow crushing is carried out under anaerobic conditions; the air pressure of the airflow crushing is at 0.8MPa, and the working temperature is -3°C; the above steps are carried out at an ambient temperature of -5°C;

[003...

Embodiment 3

[0038] Step 1, raw material processing: take povidone K30, ethyl cellulose, stearic acid, microcrystalline cellulose and pulverize them, add them into nano-grinding machine for powdering for later use;

[0039] Step 2, powder making: take the royal jelly in step 1 and treat it with electricity for 30 minutes, the power supply voltage is 5V, and then the pre-royal jelly is vacuum freeze-dried at low temperature and hydraulically formed into flakes; the flake royal jelly is added to a powder machine for coarse crushing, and then added to an ultra-fine grinder for crushing , to obtain 400 mesh fine particles; the crushed fine particles are added to a low-temperature airflow mill, and 12 parts of 1000 mesh royal jelly powder are obtained after crushing; and the airflow crushing is carried out in a vacuum environment or anaerobic conditions, and the vacuum environment is that the vacuum degree is -0.08MPa; the air pressure of jet milling is 3MPa, and the working temperature is -7℃; ...

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PUM

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Abstract

The invention discloses a royal jelly pellet lozenge. The royal jelly pellet lozenge is prepared from the following raw materials: royal jelly pellets, saccharose powder, microcrystalline cellulose, stearic acid, mannitol or xylitol. Besides, the invention further discloses a preparation method of the royal jelly pellet lozenge. By virtue of a preparation, the dissolving-out speeds and in-vivo absorbing effects of active ingredients of the medicine are increased, the bioavailability is substantially increased, an ideal drug release speed and expected blood concentration can be obtained, a peak valley phenomenon is avoided, and a relatively long action time can be achieved; and the royal jelly pellet lozenge is capable of refreshing breath and is convenient to take.

Description

technical field [0001] The invention belongs to a buccal tablet, in particular to a royal jelly pellet buccal tablet and a preparation method thereof. Background technique [0002] Royal jelly is good for life and prolonging life, regulating immunity, improving sleep, improving memory, skin care and beauty, etc. It is also a precious natural food of choice for patients with diabetes, cardiovascular and cerebrovascular diseases, tumors, hepatitis, stomach problems, and frail middle-aged and elderly people. [0003] In an "acid" environment, such as gastric acid in the body, the essence of royal jelly - royal jelly will deteriorate. Therefore, royal jelly is not suitable for oral absorption. And although the traditional method of taking can stimulate the efficacy of the medicine, the stimulation of the efficacy of the medicine is not thorough, resulting in a waste of medicinal materials, and the phenomenon of peaks and valleys is prone to occur, which affects the actual effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K35/644A61P39/06A61P37/04A61P25/20A61P25/28A61P17/00
Inventor 夏钊陈仲慧廖雪松
Owner HUNAN ZHONGJIAN XINYUAN BIO TECH
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