Device and method for continuously producing beta-ionone by using microchannel

Abstract

The invention discloses a device and method for continuously producing beta-ionone by using microchannel. The method comprises the following steps: preparing a pseudoionone organic solvent into a pseudoionone solution in volume percentage of 30-70%, adding the pseudoionone solution and concentrated sulfuric acid into a microchannel reactor respectively through two inlets of the microchannel reactor, reacting at a temperature of 25-30 DEG C, enabling reactant to flow out of the microchannel reactor, carrying out phase splitting treatment on the reactant by using a phase splitter to obtain a water phase and an oil phase containing beta-ionone, and treating the oil phase containing beta-ionone to obtain beta-ionone oily liquid. The method is convenient to operate and easily controllable in condition; the produced beta-ionone is high in yield and high in purity; the large-scale industrial production is facilitated; the microchannel reactor has extremely high heat exchange efficiency and is capable of preventing local temperature from excessively high, eliminating hot-spot temperature and improving the purity of the product which is beta-ionone; the continuous product is achieved; the production efficiency is improved; the copious cooling condition is avoided; the energy consumption is reduced; the cost is reduced.

Description

technical field [0001] The invention relates to a device and method for continuously producing β-ionone by using a microchannel. Background technique [0002] β-ionone is an important synthetic spice and an important intermediate for the synthesis of vitamin A in the pharmaceutical industry. It can be cyclized under acidic conditions after condensing citral and acetone to generate pseudo-ionone. According to the position of the double bond of ionone, there are three isomers of α, β and γ. The product of cyclization synthesis is usually a mixture of α-, β-ionone. In the synthesis of vitamin A in the pharmaceutical industry, the purity of β-ionone has a great influence on the product. Therefore, it is the key to the development of β-ionone preparation technology to be able to prepare high-purity β-ionone simply and in large quantities. [0003] [0004] At present, the synthesis of ionone mainly revolves around how to increase the content of β-ionone in the cyclization pr...

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Problems solved by technology

Chinese patent CN 1109462A has introduced the addition of 2-hydroxy-4-octyloxybenzophenone compound as translocation preventive agent in the cyclization reaction, but the phase transfer catalyst and transposition preventive agent used are expensive and cannot be recycled. conducive to industrialization

German patent DE.3328440 proposed a method of producing β-ionone by instant contact between pseudoionone and sulfuric acid at room temperature, but this method requires special equipment and difficult condition control, so it has not been widely used

Chinese patent CN1129209A introduces a method of completing the cyclization reaction under the action of ultrasonic waves, but the ultrasonic device consumes a lot of energy, and it is difficult to realize industrial production

In Chinese patent CN02155069.7, dry ice is added in batches in the cyclization reaction to prevent local overheating, but the processing capacity is small and the production efficiency is not high

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