Polyester type polyurethane material with side chain containing phosphorylcholine group and preparation method thereof
A polyester polyurethane and polyurethane material technology, applied in the field of medical polymer materials, can solve the problems of limited biocompatibility, degradation of toxic substances, and difficulty in enrichment, etc., and achieve high biocompatibility, high mechanical Strength, thrombus avoidance effect
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[0039] Example 1
[0040] 0.01mol poly L-lactide (PLLA, M n =2000) and 0.02mol HDI-BDO-HDI (dissolved in dimethyl sulfoxide: 10g / 30mL) were placed in a three-necked flask, protected by dry nitrogen, mechanically stirred, heated to 80°C, reacted for 4.0h, and cooled to 18 ℃, add 0.01mol Lys-PC and stir. When the viscosity of the system becomes too large and the system cannot be stirred normally, add an appropriate amount of dichloromethane. After stirring for 1h, add dichloromethane to a concentration of about 15wt%. The ice ether settles, suction filtration, and normal temperature. Vacuum drying to constant weight, a polyurethane material A1 containing phosphorylcholine groups in the side chain is obtained.
[0041] Preparation of membrane material: Dissolve A1 in the organic solvent dioxane to prepare a solution with a concentration of 6.5% (g / mL). Use a polytetrafluoroethylene mold to volatilize at 25°C under normal pressure for 80 hours, and remove the membrane from the mold. A...
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[0042] Example 2
[0043] The 0.01mol polyε-caprolactone (PCL, M n =2000) and 0.02mol HDI-BDO-HDI (dissolved in dimethyl sulfoxide: 10g / 30mL) were placed in a three-necked flask, protected by dry nitrogen, mechanically stirred, heated to 85°C, after 3.5 hours of reaction, cooled to 18 ℃, add 0.01mol Lys-PC and stir. When the viscosity of the system becomes too large and the system cannot be stirred normally, add an appropriate amount of dichloromethane. After stirring for 1h, add dichloromethane to a concentration of about 15wt%. The ice ether settles, suction filtration, and normal temperature. After vacuum drying to constant weight, a polyurethane material A2 containing phosphorylcholine groups in the side chain is obtained.
[0044] Preparation of the membrane material: Dissolve A2 in the organic solvent chloroform, prepare a solution with a concentration of 5.5% (g / mL), use a polytetrafluoroethylene mold to volatilize at 24°C and normal pressure for 90 hours, and remove the mem...
Example Embodiment
[0045] Example 3
[0046] The 0.01mol polyε-caprolactone (PCL, M n =1500) and 0.02mol HDI-BDO-HDI (dissolved in dimethyl sulfoxide: 10g / 30mL) were placed in a three-necked flask, protected by dry nitrogen, mechanically stirred, heated to 85°C, and reacted for 3.5 hours, then cooled to 18 ℃, add 0.01mol Lys-PC and stir. When the viscosity of the system becomes too large and cannot be stirred normally, add an appropriate amount of dichloromethane. After stirring for 1.5h, add dichloromethane to a concentration of about 15wt%. The ice ether settles and suction filtration. Vacuum drying at room temperature to constant weight to obtain a polyurethane material A3 containing phosphorylcholine groups in the side chain.
[0047] Preparation of the membrane material: Dissolve A3 in the organic solvent chloroform, prepare a solution with a concentration of 4% (g / mL), use a polytetrafluoroethylene mold to volatilize at 15°C and normal pressure for 60 hours, and remove the membrane from the mol...
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