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Aryl propionic acid type nonsteroidal anti-inflammatory drug patch and preparation method thereof

A technology of non-steroidal anti-inflammatory drugs and aryl propionic acids, applied in the field of medicine, can solve problems such as non-soft adhesion, skin irritation, pain in patients, etc. low effect

Active Publication Date: 2017-05-24
SANCA MEDICAL TECH TIANJIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Another object of the present invention is to provide a method for preparing a patch of arylpropionic acid NSAIDs suitable for people with sensitive skin, especially Asian groups or children, which solves the problem of sticking of existing patches. Not soft, irritating to the skin, easy to cause pain to the patient, and even damage the skin

Method used

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  • Aryl propionic acid type nonsteroidal anti-inflammatory drug patch and preparation method thereof
  • Aryl propionic acid type nonsteroidal anti-inflammatory drug patch and preparation method thereof
  • Aryl propionic acid type nonsteroidal anti-inflammatory drug patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 ibuprofen patch and preparation method thereof:

[0039] prescription:

[0040] Styrene-isoprene-styrene copolymer 50wt.%

[0041] Ibuprofen 11wt.%

[0042] Hydrogenated Rosin 20wt.%

[0043] Liquid paraffin 16.5wt.%

[0044] Azone and propylene glycol (1:5 by volume) 2wt.%

[0045] Antioxidant HBT 0.5wt.%

[0046] Preparation:

[0047] 1) Take styrene-butadiene-styrene block copolymer and butyl acetate at a mass ratio of 1:3, soak the styrene-butadiene-styrene block copolymer in butyl acetate at 25°C 16h, stir evenly, obtain colloid, set aside;

[0048] 2) Take the colloid prepared in step 1), ibuprofen, hydrogenated rosin, liquid paraffin, azone, propylene glycol (volume ratio 1:5), and antioxidant, heat and mix at 60° C. to obtain a drug adhesive layer;

[0049] 3) The backing layer paper, the drug adhesive layer prepared in step 2) and the protective layer PET film are prepared into a drug patch in a coating machine.

Embodiment 2

[0050] Embodiment 2 ibuprofen patch and preparation method thereof:

[0051] prescription:

[0052] Styrene-isoprene-styrene copolymer 40wt.%

[0053] Ibuprofen 15wt.%

[0054] C9 petroleum resin and terpene resin (mass ratio is 1:1) 30wt.%

[0055] Vaseline 12.5wt.%

[0056] Azone and propylene glycol (1:1 by volume) 2wt.%

[0057] Antioxidant HBT0.5wt.%

[0058] Preparation:

[0059] 1) Take styrene-butadiene-styrene block copolymer and ethyl acetate at a mass ratio of 1:5, soak the styrene-butadiene-styrene block copolymer in ethyl acetate at 40°C 24h, stir evenly, obtain colloid, set aside;

[0060] 2) Take the colloid prepared in step 1), ibuprofen, C9 petroleum resin and terpene resin, vaseline, azone, propylene glycol (volume ratio of 1:1), antioxidant, heat and mix at 60°C to obtain the drug adhesive layer;

[0061] 3) The backing layer paper, the drug adhesive layer prepared in step 2) and the protective layer PET film are prepared into a drug patch in a coat...

Embodiment 3

[0062] Embodiment 3: Ketoprofen patch and preparation method thereof

[0063] prescription:

[0064] Styrene-isoprene-styrene copolymer 20wt.%

[0065] Ketoprofen 6wt.%

[0066] C9 petroleum resin and terpene resin (mass ratio is 1:1) 50wt.%

[0067] Lanolin 20wt.%

[0068] Azone and propylene glycol (1:1 by volume) 3wt.%

[0069] Antioxidant 10101wt.%

[0070] Preparation:

[0071] 1) Take styrene-butadiene-styrene block copolymer and ethyl acetate at a mass ratio of 1:1, soak the styrene-butadiene-styrene block copolymer in ethyl acetate at 20°C 24h, stir evenly, obtain colloid, set aside;

[0072] 2) Take the colloid prepared in step 1), ketoprofen, C9 petroleum resin and terpene resin, lanolin, azone and propylene glycol (volume ratio is 1: 1), antioxidant, heat and mix evenly at 40 ° C to obtain Drug adhesive layer;

[0073] 3) The backing layer paper, the drug adhesive layer prepared in step 2) and the protective layer PET film are prepared into a drug patch in ...

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PUM

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Abstract

The invention provides an aryl propionic acid type nonsteroidal anti-inflammatory drug patch and a preparation method thereof. The patch of the invention comprises a backing layer and a drug sticking layer. The drug sticking layer contains a styrene-isoprene-styrol copolymer, a tackifier, a softener, a transdermal penetration enhancer and an anti-oxidant. The patch also comprises an aryl propionic acid type nonsteroidal anti-inflammatory drug. By the new drug delivery form of the aryl propionic acid type nonsteroidal anti-inflammatory drug, the patch of the invention has positive effects on patients who need external application of the aryl propionic acid type nonsteroidal anti-inflammatory drug and is suitable for those who have skin allergy. The problem that existing patches are not soft in adhesion, are irritating to the skin, are easy to cause pain for patients and even damage the skin is solved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an aryl propionic acid non-steroidal anti-inflammatory drug patch and a preparation method thereof, in particular to an ibuprofen patch and a preparation method thereof. Background technique [0002] Transdermal patches are the third generation of drug dosage forms after oral and injections. In the 1980s, with the successful listing of scopolamine patches by Alza Company of the United States, they emerged. These preparations are collectively referred to as "transdermal drug delivery systems", namely Drugs are absorbed through the skin and act systemically or locally. The plaster in my country can be regarded as a patch of the modern new dosage form "transdermal drug delivery preparation". After the Second World War, the rapid development of synthetic rubber, synthetic resin, etc., and the advent of new polymer materials such as polypropylene, etc., provided a basis for the technological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/192A61K47/32A61P29/00
Inventor 崔建平
Owner SANCA MEDICAL TECH TIANJIN