A kind of synthetic method of propyl p-hydroxybenzoate

A technology of propyl hydroxybenzoate and synthesis method, which is applied in the field of biocatalytic synthesis, can solve problems such as unreported research, and achieve the effects of low equipment requirements, low cost, and mild reaction
CN106701848BActive Publication Date: 2020-05-08ANHUI POLYTECHNIC UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ANHUI POLYTECHNIC UNIV
Publication Date
2020-05-08

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Abstract

The invention discloses a synthesis method of propyl p-hydroxybenzoate. The synthesis method comprises immobilized bio-imprinting enzyme. An imprinting system of the bio-imprinting enzyme is prepared from tannase, p-hydroxybenzonic acid and kieselguhr according to a mass ratio of (0.1-1): (1-3): 10. A buffer solution for fixing the immobilized bio-imprinting enzyme is an acetic acid buffer solution which has a pH value of 6.0 and the concentration of 100mM. According to the synthesis method, the propyl p-hydroxybenzoate is catalytically synthesized by using the immobilized bio-imprinting tannase, and a compound solvent system of the n-propyl alcohol-acetic acid buffer solution is used for improving the catalytic efficiency. After the method is adopted, the substrate conversion rate reaches 26.5%. The method is mild in reaction, low in energy consumption and less in pollution, and is an efficient, convenient and fast production way, so that a new way is provided for realizing the green and efficient production of propyl p-hydroxybenzoate.
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Description

technical field

[0001] The invention relates to a method for synthesizing propyl p-hydroxybenzoate, belonging to the technical field of biocatalytic synthesis. Background technique

[0002] Propyl p-hydroxybenzoate is an internationally recognized safe, efficient and broad-spectrum preservative. It has the characteristics of extremely low toxicity, non-irritating and relatively stable in a wide pH range. It has a wide range of antibacterial effects on mold, yeast and bacteria. It has always been a widely used preservative in cosmetics and pharmaceuticals. Propyl p-hydroxybenzoate has a certain influence in experiments in the field of life science research, and can be used in biochemical research and tissue culture. At present, the commonly used production method of propyl p-hydroxybenzoate is mainly based on the esterification reaction of chemical catalyst. The traditional chemical catalysis method is carried out under high temperature, high pressure and strong corrosive c...

Claims

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