Method for determining residue of sulfur dioxide in traditional Chinese medicinal material by using ICP-MS (Inductively Coupled Plasma Mass Spectrometry) method

An ICP-MS, sulfur dioxide technology, applied in measurement devices, analysis materials, material analysis by electromagnetic means, etc., to achieve good preservation, low detection limit, and good reproducibility.

Active Publication Date: 2017-05-31
云南同创检测技术股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Inductively coupled plasma mass spectrometry (ICP-MS) has the characteristics of strong anti-interference ability, high detection sensitivity, fast analysis speed, less sample consumption, and wide dynamic linear range. Method Report on Sulfur Dioxide Residue

Method used

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  • Method for determining residue of sulfur dioxide in traditional Chinese medicinal material by using ICP-MS (Inductively Coupled Plasma Mass Spectrometry) method
  • Method for determining residue of sulfur dioxide in traditional Chinese medicinal material by using ICP-MS (Inductively Coupled Plasma Mass Spectrometry) method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take samples of Radix Paeoniae Alba and Radix Puerariae, and crush them with a cyclone mill to pass through a 40-mesh sieve. Weigh sodium sulfate and dilute it step by step with water to prepare a sulfur element standard working solution with a sulfur element concentration ranging from 0 to 20.0 mg / L, and use distilled water as a standard blank solution. Dilute with distilled water to obtain a 1mol / L hydrochloric acid solution. Dilute with 5% nitric acid solution to obtain a germanium solution with a concentration of 1.0 mg / L.

[0035] Weigh 5 grams of Chinese herbal medicine powder, add 40 mL of 1 mol / L hydrochloric acid solution, shake well, and place on a steam distillation apparatus. The parameters of the steam distillation apparatus are: the steam intensity is 100%, the distillation time is 5 minutes, and the distillation ends When the distillate was about 140mL, it was diluted with distilled water to 200mL to obtain the sample solution to be tested; except that t...

Embodiment 2

[0042] Samples of Chinese medicinal materials Huai Yam and Fritillaria fritillaria were taken and pulverized by a cyclone mill through a 60-mesh sieve. Weigh potassium sulfate and dilute it step by step with water to prepare a standard working solution with a sulfur element content of 0-200.0 mg / L, and use distilled water as a standard blank solution. Dilute with distilled water to obtain a 0.5 mol / L phosphoric acid solution. Dilute with 5% nitric acid solution to obtain a rhodium solution with a concentration of 1.0 mg / L.

[0043] Weigh 3 grams of Chinese medicinal material powder, add 100 mL of 0.5 mol / L phosphoric acid solution, shake well, and place on a steam distillation apparatus. The parameters of the steam distillation apparatus are: the steam intensity is 90%, the distillation time is 6 minutes, and the distillation At the end, the distillate was about 100mL, diluted with distilled water to 200mL to obtain the sample solution to be tested; except that no sample powd...

Embodiment 3

[0050] Samples of Chinese herbal medicine Gastrodia elata and lily were taken and pulverized by a cyclone mill through a 20-mesh sieve. Weigh sodium sulfate and dilute it step by step with water to prepare a sulfur standard working solution of 0-200.0 mg / L, and use distilled water as the standard blank solution. Dilute with distilled water to obtain a 1mol / L sulfuric acid solution. Dilute with 5% nitric acid solution to obtain an indium solution with a concentration of 1.0 mg / L.

[0051] Weigh 10 grams of Chinese herbal medicine powder, add 30 mL of 3 mol / L sulfuric acid solution, shake well, and use an ordinary steam distillation device to carry out steam distillation. When the distillate is about 200 mL, the sample solution to be tested is obtained; except that no sample In addition to the powder, the standard blank solution was obtained in the same way.

[0052] The tuning liquid tunes the ICP-MS to the best working environment, and the working conditions of the instrumen...

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Abstract

The invention discloses a method for determining residue of sulfur dioxide in a traditional Chinese medicinal material by using an ICP-MS (Inductively Coupled Plasma Mass Spectrometry) method. The method comprises: firstly, crushing the traditional Chinese medicinal material, weighing sample powder of the traditional Chinese medicinal material, adding an acid solution, performing distillation and extraction by using a vapor distillation method, absorbing by using distilled water, sizing sulfur dioxide released by distillation, and shaking up to obtain a to-be-detected sample solution; then, preparing a sulfur element standard working solution, determining the concentration of a sulfur element in the to-be-detected sample solution by using the ICP-MS method, and performing calculation to obtain the residual content of the sulfur dioxide in the traditional Chinese medicinal material. The method is high in detection sensitivity, high in analysis speed, small in consumed sample amount, low in detection limit of the sulfur dioxide, and high in adding standard recovery.

Description

technical field [0001] The invention relates to the technical field of inspection of Chinese medicinal materials, in particular to a method for determining residual sulfur dioxide in Chinese medicinal materials. Background technique [0002] Fumigation of Chinese herbal medicines with sulfur, as a relatively traditional process, can play a role in whitening, anti-mildew, anti-moth, and beneficial to the storage of medicinal materials. Sulfur burns during fumigation to produce sulfur dioxide gas. Sulfur dioxide is a strong reducing agent, which may cause changes in the active ingredients in Chinese medicinal materials and affect the quality and curative effect of Chinese medicinal materials. If the pharmaceutical preparation contains excessive sulfur dioxide, it will damage the mucous membrane of the digestive tract and respiratory system of the user who takes the medicine, and also cause damage to the liver, kidney and other organs. The 2015 edition of the "Pharmacopoeia" s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
Inventor 段姚俊袁仕信刘磊候英黄伟初吴建伟和玉凤杨燕
Owner 云南同创检测技术股份有限公司
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