Sodium fructose diphosphate compound and preparation method thereof

A technology of sodium fructose diphosphate and compounds, which is applied in the field of medicine, can solve the problems that cannot reflect the contribution of the new crystallization process safety, and achieve good anti-microbial erosion ability, increased safety, and low hygroscopicity.

Active Publication Date: 2019-04-02
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has introduced sodium acetate in the ethanol system of crystallization, has improved the yield of crystallization, but in test example, fructose-1,6-trisodium diphosphate solid dissolving after crystallization is done hemolysis and irritation test, can't Reflect the contribution of this new crystallization process to its safety

Method used

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  • Sodium fructose diphosphate compound and preparation method thereof
  • Sodium fructose diphosphate compound and preparation method thereof
  • Sodium fructose diphosphate compound and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0053] In parts by weight, the raw materials selected in this embodiment include:

[0054]

[0055] The preparation method is as follows:

[0056] (1) Add the above-mentioned raw materials into the reactor, and react for 10 hours at a pH of 6.0 and a temperature of 37° C.;

[0057] (2) the product of the reaction described in step (1) is filtered through a ceramic membrane, and the filtrate is collected;

[0058] (3) The filtrate described in step (2) is passed through 732 cation exchange resins, after diluting the effluent with deionized water, it is adsorbed by 717 anion exchange resins, after using lye to remove miscellaneous ions, elute with sodium chloride solution, get eluent;

[0059] (4) Concentrate the eluate described in step (3) by nanofiltration, and when the concentration of the solution reaches 35%, add activated carbon for needle decolorization to the solution and filter and adjust the pH to 6.0 to obtain a concentrated solution;

[0060] (5) Add ethanol t...

Embodiment 2

[0064] In parts by weight, the raw materials selected in this embodiment include:

[0065]

[0066] The preparation method is as follows:

[0067] (1) Put the above-mentioned raw materials into the reactor, and react for 8.5 hours under the conditions of pH 6.0 and temperature 37°C;

[0068] (2) the product of the reaction described in step (1) is filtered through a ceramic membrane, and the filtrate is collected;

[0069] (3) The filtrate described in step (2) is passed through 732 cation exchange resins, after diluting the effluent with deionized water, it is adsorbed by 717 anion exchange resins, after using lye to remove miscellaneous ions, elute with sodium chloride solution, get eluent;

[0070] (4) Concentrate the eluate described in step (3) by nanofiltration, and when the concentration of the solution reaches 35%, add activated carbon for needles to the solution for decolorization, filter and adjust the pH to 5.3 to obtain a concentrated solution;

[0071] (5) A...

Embodiment 3

[0075] In parts by weight, the raw materials selected in this embodiment include:

[0076]

[0077] 14 parts of toluene

[0078] 4 parts ammonia water

[0079] Purified water 1800 parts

[0080] The preparation method is as follows:

[0081] (1) Add the above-mentioned raw materials into the reactor, and react for 8 hours under the conditions of pH 6.0 and temperature 37°C;

[0082] (2) the product of the reaction described in step (1) is filtered through a ceramic membrane, and the filtrate is collected;

[0083] (3) The filtrate described in step (2) is passed through 732 cation exchange resins, after diluting the effluent with deionized water, it is adsorbed by 717 anion exchange resins, after using lye to remove miscellaneous ions, elute with sodium chloride solution, get eluent;

[0084] (4) Concentrate the eluate described in step (3) by nanofiltration, and when the concentration of the solution reaches 37%, add activated carbon for needles to the solution for de...

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Abstract

The invention relates to the field of medicine, in particular to a fructose diphosphate compound. An X-ray diffraction spectrum of the fructose diphosphate compound is shown as Figure 1. The invention further provides a preparation method of the fructose diphosphate compound. The preparation method includes: adopting raw materials including beer yeast, glucose, phosphoric acid and magnesium carbonate for fermentation; filtering, and performing ion exchange; decoloring, filtering, crystallizing and drying to obtain 1, 6-fructose diphosphate trisodium hydrate. The fructose diphosphate compound produced by the method is lower in hygroscopicity, higher in stability and conducive to production and application of injections; due to unique crystal form of the fructose diphosphate compound, oral administration bioavailability is improved, and the fructose diphosphate compound is suitable for production and application of tablets.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a sodium fructose diphosphate compound and a preparation method thereof. Background technique [0002] Sodium fructose diphosphate, molecular formula: C 6 h 11 o 12 P 2 Na 3 ·8H 2 O, the structural formula is as follows: [0003] [0004] Sodium fructose diphosphate is white or off-white crystalline powder, which is easy to absorb moisture. Soluble in water, insoluble in organic solvents such as ethanol. Slightly fragrant, slightly salty taste, dry product is stable at room temperature. [0005] Sodium fructose diphosphate is an important intermediate product in the process of glucose metabolism in the human body, and it is a metabolic regulator at the molecular level. Its trisodium salt, that is, this product can increase the concentration of adenosine triphosphate and creatine phosphate in cells by regulating the activity of several enzymes in glucose metabolism, promote the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H11/04C07H1/04A61K31/7024A61P9/10A61P3/08A61K9/14
CPCA61K9/0019A61K9/14C07B2200/13C07H1/04C07H11/04
Inventor 黄毅陈敏钱国佩陈浩张晓鹏
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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