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Drug-loading nano fiber having sheath and containing double-core structural feature and preparation method thereof

A technology with structural characteristics and drug-loaded nanometers, which is applied in the field of materials science, can solve the problems that the slow-release effect of nanofibers cannot be effectively controlled, and achieve the effects of significant technological progress, uniform diameter distribution, and simple preparation process

Inactive Publication Date: 2017-06-13
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a drug-loaded nanofiber with a sheath-containing double-core structure and a preparation method thereof. The drug-loaded nanofiber with a sheath with a double-core structure The preparation method thereof shall solve the technical problem that the slow-release effect of nanofibers in the prior art cannot be effectively controlled

Method used

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  • Drug-loading nano fiber having sheath and containing double-core structural feature and preparation method thereof
  • Drug-loading nano fiber having sheath and containing double-core structural feature and preparation method thereof
  • Drug-loading nano fiber having sheath and containing double-core structural feature and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: Implementation of multi-jet electrospinning process

[0026] Dissolve 8 grams of polyvinylpyrrolidone and 1 gram of ketoprofen in 100 grams of ethanol to prepare the working fluid of the sheath.

[0027] 13 grams of Eudragit E-100 and 1 gram of ketoprofen were dissolved in 100 grams of ethanol to prepare the working fluid on one side of the parallel core.

[0028] Co-dissolve 13 grams of Eudragit L-100 and 3 grams of ketoprofen in 100 grams of ethanol to prepare the working fluid on the other side of the parallel core.

[0029] Put the above solutions into the corresponding syringes respectively, and install them on the corresponding syringe pumps, connect each working fluid to each inlet of the three-stage combined spinning head, and connect the high-voltage spinning head and the high-voltage electrostatic generator.

[0030] The high-voltage electrospinning process was implemented according to the following parameters: the flow rate of the sheath liquid...

Embodiment 2

[0033] Example 2: Characterization analysis of the morphology and structure of three-stage controlled-release electrospun drug-loaded nanofibers

[0034] Field emission scanning electron microscopy (FESEM) was used to observe the surface of the fiber prepared in Example 1 after spraying gold, and the results were as follows Figure 4 shown. The prepared fiber exhibits a good linear state, no beaded structure, smooth fiber surface and uniform fiber accumulation. The diameter is 680 ± 120 nm, the distribution is relatively uniform, and the diameter distribution is relatively concentrated.

[0035] The internal structure of the prepared fiber was observed by high-resolution transmission electron microscope (TEM), and the results were as follows: Figure 5 As shown, the sheath of the nanofiber has a clear structure of parallel double cores, including two parallel inner cores, the outer peripheries of the two inner cores are provided with an outer sheath, the outer sheath and the...

Embodiment 3

[0037] Example 3: The sustained and controlled release performance of ketoprofen provided by three-stage controlled release electrospun drug-loaded nanofibers

[0038] According to the 2015 edition of Chinese Pharmacopoeia Appendix ⅩD Release Test Method 2, the RCZ-8A intelligent dissolution tester was used to conduct the in vitro dissolution test on the drug-loaded nanofibers obtained above. The control speed is 50rpm, and the temperature is 37±0.1°C. In the first 2 hours, 900 mL of artificial gastric juice without enzymes was used as the dissolution medium, and 900 mL of artificial intestinal juice (pH6.8 phosphate buffer solution) without enzymes was used as the dissolution medium later to investigate the properties of nanofibers with drug radial isolation distribution characteristics. Controlled drug release properties in vitro. Sampling 5mL at the scheduled time, filtering through a 0.22µm microporous membrane to obtain a sample of the eluate, and immediately replenishin...

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Abstract

The invention provides a drug-loading nano fiber having a sheath and containing a double-core structural feature. The nano fiber comprises two inner core parts, wherein the periphery of the two inner core parts is provided with an outer sheath part; the outer sheath part and the inner core parts extend in the length direction; the outer sheath part is composed of a water-soluble polymer; one inner core part is composed of a stomach dissolving type polymer, and the other inner core part is composed of an intestine dissolving type polymer; and drugs are contained in the outer sheath part and the two inner core parts. The invention also provides a preparation method of the nano fiber. According to the invention, different polymer base materials are used for the sheath part and the core parts, and three-stage gradual release of loaded drugs can be regulated by the nano fiber under the structural support. The method provided by the invention is simple in preparation process and realizes single-step effectiveness; the parallel structure contained in the prepared nano fiber sheath is clean; and the nano fiber is small in diameter, favorable in linearity, uniform in diameter distribution and smooth in fiber surface.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a technology for establishing a structure-activity relationship of a novel nano-level substance, in particular to a drug-loaded nanofiber with a double-core structure in a sheath and a preparation method thereof. Background technique [0002] High-voltage electrospinning technology (electrospinning) is a top-down nano-manufacturing technology. The jet is formed by overcoming the liquid surface tension and viscoelastic force of the droplets at the tip of the nozzle by applying an electric field force. Under the joint action of Coulomb force and surface tension, the atomized liquid jet is bent, stretched, and split by high frequency, and is stretched tens of millions of times within tens of milliseconds. After solvent volatilization or melt cooling, nanometer particles are obtained at the receiving end. grade fiber. This technology has simple process, convenient operation, wide se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61K49/12A61K49/18A61K31/192
CPCA61K9/0092A61K9/0002A61K31/192A61K47/32A61K49/12A61K49/1884
Inventor 余灯广李海鹏李娇娇王庆邓扬超
Owner UNIV OF SHANGHAI FOR SCI & TECH
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