Nanofiber capable of providing slow controlled release of medicines after pulse and preparation method of nanofiber

A technology of nanofibers and drugs, applied in the field of materials science, can solve problems such as poor effects, and achieve the effect of clear juxtaposition structure, simple preparation process, and smooth fiber surface

Inactive Publication Date: 2017-06-23
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a nanofiber capable of providing slow and controlled drug release after a pulse and a preparation method thereof. The nanofiber capable of providing a slow and controlled release of a drug after a pulse and its preparation method solve the problem of nanofiber control in the prior art. Technical issues with poor efficacy of extended-release drugs

Method used

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  • Nanofiber capable of providing slow controlled release of medicines after pulse and preparation method of nanofiber
  • Nanofiber capable of providing slow controlled release of medicines after pulse and preparation method of nanofiber
  • Nanofiber capable of providing slow controlled release of medicines after pulse and preparation method of nanofiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Implementation of electrospinning process and preparation of side-by-side nanofibers

[0029] Co-dissolve 2 g of paracetamol and 7 g of polyvinylpyrrolidone K60 in 100 ml of absolute ethanol to prepare a side-by-side working fluid of fiber bundles.

[0030] Co-dissolve 4 g of the drug acetaminophen and 20 g of the fiber-forming polymer ethylcellulose in 100 ml of absolute ethanol to prepare the working fluid on one side of the main fiber bundle.

[0031] Put the above two kinds of working fluids into the corresponding syringes 7 and 8 respectively, install them on the respective syringe pumps 2 and 3, and connect them to the two inlets of the parallel spinning head 4, connect the high-pressure spinning head 4 and the high-pressure generator 1.

[0032] The speed of injecting the parallel solution into the parallel spinning head 4 is controlled respectively by two syringe pumps 2 and 3, the parallel flow rate is 1.0 mL / h, the distance between the fiber receiv...

Embodiment 2

[0035] Example 2: Structural and Morphological Characterization of Slow Controlled Release Nanofibers After Drug Pulse

[0036] Field emission scanning electron microscopy (FESEM) was used to observe the surface of the fiber prepared in Example 1 after spraying gold, and the results were as follows image 3 shown. The prepared fiber exhibits a good linear state, no beading structure occurs, the fiber surface is smooth, and the fiber accumulation is uniform. The diameter is 720 ± 150 nm, the distribution is relatively uniform, and the diameter distribution is relatively concentrated.

[0037] The internal structure of the prepared fiber was observed by high-resolution transmission electron microscope (TEM), and the results were as follows: Figure 4 As shown, the bilateral side-by-side structural features of nanofibers are clear. The internal structure of the fiber is as Figure 5 As shown, the drug 33 is evenly distributed on both sides of the Jonas nanofibers. One side 1...

Embodiment 3

[0038] Example 3: Drug controlled release function analysis of slow controlled release nanofibers after drug pulse

[0039] According to the 2015 edition of Chinese Pharmacopoeia Appendix ⅩD Release Test Method 2, the RCZ-8A intelligent dissolution tester was used to conduct the in vitro dissolution test on the drug-loaded nanofibers obtained above. The control speed was 50rpm, the temperature was 37±0.1°C, and the dissolution medium was 900 mL pH7.0 phosphate buffer solution to investigate the drug release performance of nanofibers in vitro. Sampling 5mL at the scheduled time, filtered through a 0.22 µm microporous membrane to obtain the eluate sample, and immediately replenished with the same volume of isothermal fresh medium. After proper dilution of the sample, ultraviolet measurement was carried out at λ = 258 nm using a UV-Vis spectrophotometer, and the dissolution amount and cumulative dissolution percentage of the drug paracetamol were calculated, repeated 6 times. Th...

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Abstract

The invention provides a nanofiber capable of providing slow controlled release of medicines after pulse. The nanofiber comprises a main fiber bundle, wherein a parallel fiber bundle is arranged at the outer side of the main fiber bundle, the main fiber bundle and the parallel fiber bundle extend in the length direction, in the radial cross section, the parallel fiber bundle covers the periphery of the main fiber bundle by 40-70 %, and the main fiber bundle is composed of a medicine and a polymer pharmaceutic adjuvant insoluble in water; the parallel fiber bundle is composed of a medicine and a pharmaceutical adjuvant easily soluble in water. The invention further provides a preparation method of the nanofiber. The preparation method comprises the following steps: blending the medicine and the polymer pharmaceutical adjuvant insoluble in water into a consolute solution, and blending the medicine and the pharmaceutical adjuvant easily soluble in water into a consolute solution; controlling the rate of being injected into parallel spinning heads of the two solutions by adopting two injection pumps, and under the effect of high-voltage static electricity, by taking the outlets of the parallel spinning heads as a template, collecting the nanofiber by adopting a grounded fiber receiving flat plate; and preparing the nanofiber capable of providing slow controlled release of medicines after pulse.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a nanometer material for sustained and controlled drug release, in particular to a nanofiber capable of providing slow and controlled drug release after a pulse and a preparation method thereof. Background technique [0002] High-voltage electrospinning technology (electrospinning) is a top-down nano-manufacturing technology. The jet is formed by overcoming the liquid surface tension and viscoelastic force of the droplets at the tip of the nozzle by applying an electric field force. Under the joint action of Coulomb force and surface tension, the liquid jet is bent, stretched, and split by high frequency, and is stretched tens of millions of times within tens of milliseconds. After solvent volatilization or melt cooling, nano-scale fibers are obtained at the receiving end. This technology has the advantages of simple process, convenient operation, wide selection of materials, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/38A61K31/192A61K31/167A61K31/12D01D5/32
CPCA61K9/0092A61K9/0002A61K31/12A61K31/167A61K31/192A61K47/32A61K47/38D01D5/32
Inventor 余灯广李娇娇李海鹏王庆何溢勇
Owner UNIV OF SHANGHAI FOR SCI & TECH
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