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Nanofiber with medicine material radial and reverse distribution characteristics and preparation method thereof

A technology of distribution characteristics and nanofibers, which is applied in the field of materials science, can solve the problems of poor slow-release effect of nanofibers, and achieve the effect of small nanometer diameter, simple preparation process and smooth fiber surface

Inactive Publication Date: 2017-07-07
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a nanofiber with radial and reverse distribution characteristics of pharmaceutical materials and a preparation method thereof. The nanofiber and preparation method with radial and reverse distribution characteristics of pharmaceutical materials must solve The technical problem that the sustained-release effect of nanofibers in the prior art is not good

Method used

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  • Nanofiber with medicine material radial and reverse distribution characteristics and preparation method thereof
  • Nanofiber with medicine material radial and reverse distribution characteristics and preparation method thereof
  • Nanofiber with medicine material radial and reverse distribution characteristics and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1: Implementation of coaxial electrospinning process

[0024] Put 12 grams of vinyl acetate cellulose and 1 gram of ibuprofen into 100 grams of a mixed solvent composed of acetone and N,N-dimethylformamide at a mass ratio of 3:1 to prepare the working fluid of the outer sheath. Put 6 grams of vinyl acetate cellulose and 3 grams of ibuprofen into 100 grams of a mixed solvent composed of acetone and N,N-dimethylformamide at a mass ratio of 3:1 to prepare the inner core working fluid. The working fluids of the outer sheath and the inner core are respectively filled into the corresponding syringes of the coaxial electrospinning system, quantitatively transported to the coaxial spinning head by the syringe pump, and connected to the spinning head and the high-voltage electrostatic generator. The coaxial high-voltage electrospinning process was implemented according to the following process conditions and parameters: the sheath / core fluid flow rate was 1.0 / 1.0 mL / h...

Embodiment 2

[0028] Example 2: Characterization analysis of the morphology and structure of nanofibers with the characteristics of radial and reverse distribution of pharmaceutical materials

[0029] Field emission scanning electron microscopy (FESEM) was used to observe the surface of the fiber prepared in Example 1 after spraying gold, and the results were as follows image 3 shown. The prepared fiber exhibits a good linear state, no beading structure occurs, the fiber surface is smooth, and the fiber accumulation is uniform. The diameter is 670 ± 110 nm, the distribution is relatively uniform, and the diameter distribution is relatively concentrated.

[0030] The internal structure of the prepared fiber was observed by high-resolution transmission electron microscope (TEM), and the results were as follows: Figure 4 As shown, the core-sheath structure of nanofibers is clear, and the inner core has a larger gray value due to the large drug content and large thickness. The specific str...

Embodiment 3

[0031]Example 3: The sustained and controlled release performance of ibuprofen provided by nanofibers with the characteristics of radial and reverse distribution of drug materials

[0032] According to the 2015 edition of Chinese Pharmacopoeia Appendix ⅩD Release Test Method 2, the drug-loaded nanofibers obtained above were subjected to an in vitro dissolution test using an RCZ-8A intelligent dissolution tester. The control speed is 50rpm, the temperature is 37±0.1℃, and the dissolution medium is 900mL pH7.0 phosphate buffer solution. Under these conditions, the in vitro controlled release performance of nanofiber drugs with the characteristics of radial and reverse distribution of drug materials is investigated. Sampling 5mL at the scheduled time to obtain a sample of the dissolution solution, and immediately replenish the same volume of isothermal fresh medium. After appropriate dilution of the sample, at λ max = 264 nm, the ultraviolet-visible spectrophotometer was used fo...

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Abstract

The invention provides a nanofiber with medicine material radial and reverse distribution characteristics. The nanofiber comprises an inner core part, wherein an outer sheath part is arranged at the periphery of the inner core part; the inner core part and the outer sheath part coaxially extend; medicine and polymer materials are contained in the inner core part and the outer sheath part; the concentration of the medicine is in progressive increase distribution along the fiber diameter direction from outside to inside; the concentration of the polymer materials is in progressive decrease distribution along the fiber diameter direction from outside to inside. An effective implementation method can be provided for slow controlled release material design and preparation of various kinds of novel medicine through the medicine material radial and reverse distribution structure characteristics of the nanofiber. The nanofiber has the advantages that the preparation process is simple; the single step is effective; the core sheath structure of the prepared nanofiber is clear; the nanometer diameter is small; the linearity is good; the diameter distribution is uniform; the fiber surface is smooth.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a technology for establishing a structure-activity relationship of a novel nano-level substance, specifically a nanofiber with a radial and reverse distribution characteristic of a medicinal material and a preparation method thereof. Background technique [0002] High-voltage electrospinning technology (electrospinning) is a top-down nano-manufacturing technology. The jet is formed by overcoming the liquid surface tension and viscoelastic force of the droplets at the tip of the nozzle by applying an electric field force. Under the joint action of Coulomb force and surface tension, the atomized liquid jet is bent, stretched, and split by high frequency, and is stretched tens of millions of times within tens of milliseconds. After solvent volatilization or melt cooling, nanometer particles are obtained at the receiving end. grade fiber. This technology has simple process, convenie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F1/10D01F8/02D01D5/34B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00D01D5/34D01F1/10D01F8/02
Inventor 余灯广张曼郑招斌张瑶瑶张玲玲
Owner UNIV OF SHANGHAI FOR SCI & TECH
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