Preparation method of alpha-ethyl linolenate

A technology of ethyl linolenate and fatty acid ethyl ester, which is applied in the field of separation and preparation of chemical raw materials, can solve problems such as poor realization of industrial production, high equipment requirements, and large solvent consumption, so as to reduce the risk and purity of heavy metal residues High effect with low equipment requirements

Inactive Publication Date: 2017-07-21
武汉藤欣生物工程有限公司
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the column chromatography method, the stationary phase is pure urea, and the mobile phase is petroleum ether, n-hexane, chloroform, ethyl acetate, methyl acetate and other organic solvents, but the solvent consumption is large and the product purity is low
[0008]

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of alpha-ethyl linolenate
  • Preparation method of alpha-ethyl linolenate
  • Preparation method of alpha-ethyl linolenate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1) 1000g linseed oil (α-linolenic acid content 55.6%) is mixed with 400ml absolute ethanol and 40ml sodium ethylate (20% sodium ethylate ethanolic solution) to carry out transesterification, and react at a temperature of 80°C for 1 Hours, after the reaction, ethanol was recovered, and glycerin, alkali and a small amount of ethanol were separated by standing, then washed to neutrality, vacuum-dried and dehydrated to obtain mixed fatty acid ethyl esters with a α-linolenic acid ethyl ester content of 55.3%.

[0034] 2) The mixed fatty acid ethyl ester in step 1) is removed the first-order light component through the first-stage molecular distillation, and obtains the first-stage heavy component;

[0035] 3) removing the second-order light components from the first-level heavy components in step 2) through second-level molecular distillation to obtain the second-level heavy components;

[0036] 4) The second heavy component in step 3) was removed through the third molecular...

Embodiment 2

[0043] 1) After mixing 1000g perilla oil (α-linolenic acid content 59.9%) with 500ml absolute ethanol and 8g NaOH, carry out transesterification reaction, react at a temperature of 80°C for 2 hours, reclaim ethanol after the reaction, and statically Set aside to remove glycerin, alkali and a small amount of ethanol, then wash with water until neutral, dry and dehydrate in vacuum to obtain mixed fatty acid ethyl esters with a α-linolenic acid ethyl ester content of 59.3%.

[0044] 2) The mixed fatty acid ethyl ester in step 1) is removed the first-order light component through the first-stage molecular distillation, and obtains the first-stage heavy component;

[0045] 3) removing the second-order light components from the first-level heavy components in step 2) through second-level molecular distillation to obtain the second-level heavy components;

[0046] 4) The second heavy component in step 3) was removed through the third molecular distillation to obtain 814 g of the thir...

Embodiment 3

[0053] 1) 1000g Eucommia ulmoides seed oil (α-linolenic acid content 60.3%) is mixed with 600ml absolute ethanol and 6g KOH to carry out transesterification reaction, react at a temperature of 80° C. for 2 hours, reclaim ethanol after the reaction, and statically Set aside to remove glycerin, alkali and a small amount of ethanol, then wash with water until neutral, dry and dehydrate in vacuum to obtain mixed fatty acid ethyl esters with a α-linolenic acid ethyl ester content of 59.4%.

[0054] 2) The mixed fatty acid ethyl ester in step 1) is removed the first-order light component through the first-stage molecular distillation, and obtains the first-stage heavy component;

[0055] 3) removing the second-order light components from the first-level heavy components in step 2) through second-level molecular distillation to obtain the second-level heavy components;

[0056] 4) The second heavy component in step 3) was removed through the third level molecular distillation to obta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of alpha-ethyl linolenate, wherein the preparation method includes steps of performing ester exchange reaction on vegetable oil and ethanol, and acquiring mixed fatty acid ester; performing a three-level molecular distillation on the mixed fatty acid ester, and then performing urea complexing reaction with urea and ethanol, and acquiring the high-purity alpha-ethyl linolenate. The preparation method of alpha-ethyl linolenate uses the method of combining three-level molecular distillation-urea complexing-chromatography purification, avoids the use of massive acid and alkali organic solvents; the organic solvent amount is few, and the method is performed by using the existed device, the equipment requirement is low. Moreover, the loss of the alpha-ethyl linolenate is few and the yield is high; the product purity can reach over 95%; the product purity can reach over 95%, so the method is applicable to the industrial production. Meanwhile, the preparation method takes plant oil as the raw material, reduces the requirement on the content of raw material alpha-linolenic acid, and enriches the raw material source; thus the production cost is reduced effectively, and the method has very strong practicability.

Description

technical field [0001] The invention relates to the field of separation and preparation of chemical raw materials, in particular to a preparation method of ethyl α-linolenate. Background technique [0002] α-Linoleic Acid (ALA) is all-cis octadecatrienoic acid (18:3n-3), its molecular formula is C 18 h 30 o 2 , with a molecular weight of 278.4296, belonging to Omega-3 polyunsaturated fatty acids (PUFAs), which cannot be synthesized in the human body and are essential fatty acids. EPA (docosahexaenoic acid) and DHA (eicosapentaenoic acid) (Omega-3 PUFAs) in animals cannot be directly converted by Omega-6 PUFAs, but can be converted by the same series of ALA In other words, ALA can be considered as the precursor of EPA and DHA. ALA undergoes dehydrogenation and carbon chain extension to generate a series of metabolites, among which the important products are EPA and DHA, and ALA has fewer double bonds than EPA and DHA, and its stability is better than that of EPA and DHA. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C67/48C07C67/54C07C69/587C11C3/10
CPCC07C67/48C07C67/54C07C69/587C11C3/10
Inventor 不公告发明人
Owner 武汉藤欣生物工程有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap