Core-shell nanocomposite material with hydroxyapatite-coated silver nanoparticles and preparation method thereof

Abstract

The invention provides a core-shell structure nanometer composite material of hydroxyapatite covered silver nanoparticles. The composite material is the core-shell structure nanometer composite material using silver nanoparticles as cores, using silver nanoparticle covered dopamine coating as an inner shell, and using an inner shell covered hydroxyapatite coating as an outer shell. The invention also provides a preparation method of the material. According to the method, firstly, a C4H11NO3-HCl buffer solution, a calcium salt solution and a phosphate solution are respectively prepared; then, the nanometer particles are uniformly dispersed into the C4H11NO3-HCl buffer solution, so that a layer of uniform polydopamine film is covered on the surface of the silver nanometer particles; then, the polydopamine film is dispersed into the calcium salt solution, so that the hydroxyapatite coating covers the surface of the silver nanometer particles. The material has excellent biocompatibility, lower cell toxicity and permanent antibacterial performance; the material can be used for the in vitro use of medical planting body surface coatings, bone restoration implantation materials and antibacterial auxiliary materials and the like.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a composite material of hydroxyapatite and silver for bone repair and a preparation method thereof. Background technique [0002] Bone repair and replacement surgery is usually a relatively traumatic operation, and the recovery process is relatively long. Bacterial infection is inevitable during the operation and recovery process. In order to avoid bacterial infection, it is usually necessary to use some antibiotics for a long time to prevent bacterial infection and reduce inflammation. probability. In recent decades, antibiotics such as penicillin, streptomycin, trimethoprim and tetracycline have greatly reduced the morbidity and mortality of pathogenic bacterial infection diseases, and have been widely used clinically. However, with the overuse and abuse of antibiotics, the resistance of pathogens to antibiotics is increasing, which may lead to long-term cure of pathogen ...

AI Technical Summary

Problems solved by technology

However, hydroxyapatite itself does not have antibacterial properties, and patients need to take antibiotics to prevent pathogenic bacterial infections

Images