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Composition for treatment of motor neuron disease and use thereof

A motor neuron disease and composition technology, which is applied in nervous system diseases, neuromuscular system diseases, drug combinations, etc., can solve the problem of safe, effective and low-cost drugs or health care products for motor neuron disease

Inactive Publication Date: 2017-09-01
岳茂兴 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no safe, effective and low-cost drug or health care product for motor neuron disease

Method used

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  • Composition for treatment of motor neuron disease and use thereof
  • Composition for treatment of motor neuron disease and use thereof
  • Composition for treatment of motor neuron disease and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A pharmaceutical composition comprising L-ornithine hydrochloride equivalent to 2.5 g of L-ornithine, 1.5 g of aspartic acid and vitamin B 6 10g can be added to 1000mL of 5% glucose sodium chloride injection.

Embodiment 2

[0055] A pharmaceutical composition, its component is compound amino acid injection 1000mL (containing: L-ornithine hydrochloride equivalent to L-ornithine 3.5g, aspartic acid 2.50g, arginine 8.80g, Isoleucine 8.80g, Leucine 13.60g, Lysine Acetate Equivalent to Lysine 7.51g, Methionine 1.20g, Phenylalanine 1.60g, Threonine 4.60g, Tryptophan 1.50g , valine 10.60g, histidine 4.70g, glycine 6.30g, alanine 8.30g, proline 7.10g, asparagine 0.55g, N-acetyl-L- equivalent to cysteine ​​0.60g cysteine, glutamic acid 5.70g, serine 3.70g, N-acetyl-L-tyrosine equivalent to tyrosine 0.70g), and vitamin B 6 16g and vitamin C 3g, vitamins were added to 500mL of 0.9% sodium chloride injection.

Embodiment 3

[0057] A pharmaceutical composition, its component is compound amino acid injection 1000mL (containing: the L-ornithine hydrochloride equivalent to L-ornithine 4.5g, aspartic acid 2.80g, arginine 8.30g, Isoleucine 6.50g, Leucine 12.00g, Lysine Acetate Equivalent to Lysine 7.51g, Methionine 1.60g, Phenylalanine 1.40g, Tryptophan 1.80g, Valine 10.60g , histidine 4.80g, glycine 6.20g, alanine 8.50g, proline 7.10g, asparagine 0.55g, glutamic acid 5.70g, serine 3.70g, N-acetyl equivalent to tyrosine 0.70g -L-tyrosine), and vitamin B 6 10g, vitamin B 1 3mg, vitamin B 2 3mg, vitamin B 3 40mg, pantothenic acid 8mg, biotin 0.4mg, folic acid 0.6mg, vitamin B 12 10 μg; Vitamin C 4g.

[0058] Vitamins can be directly added to compound amino acid injection, or added to 5% glucose sodium chloride injection. If you are a diabetic, you can add vitamins to 0.9% sodium chloride injection.

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PUM

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Abstract

Belonging to the field of pharmacy, the invention discloses a composition for treatment of motor neuron disease and use thereof. Per unit of the composition comprises: ornithinate equivalent to 0.5-8g of L-ornithine, 1-5g of aspartic acid, and 6-20g of vitamin B6. The composition can improve or even reverse the progress of motor neuron disease, and can be used for preparation of drugs or health-care products treating motor neuron disease. The composition has the advantages of safety and no side effect after long-term use, low treatment cost, and good effect, and is suitable for clinical popularization.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a composition for treating motor neuron disease and its application. Background technique [0002] Motor neuron disease (MND) is a group of chronic progressive degenerative diseases that selectively invade the anterior horn cells of the spinal cord, brainstem motor neurons, cortical vertebral cells and vertebral tracts with unknown etiology. It is characterized by progressive degeneration, necrosis, and apoptosis of upper and lower motor neurons. Clinically, both upper and (or) lower motor neurons are damaged, and it is a combination of muscle weakness, muscle atrophy, and vertebral tract signs. Eventually, respiratory failure often leads to death, and sensory and sphincter functions are generally not affected. Due to the different combinations of symptoms and signs, different types of motor neuron diseases are formed, including amyotrophic lateral sclerosis (ALS), spinal muscular atrophy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/4415A61K31/401A61K31/375A61P25/00A61P25/28A61P21/00
CPCA61K9/0019A61K9/0095A61K9/08A61K31/198A61K31/375A61K31/401A61K31/4415A61K47/02A61K2300/00
Inventor 岳茂兴万红贵黄彤舸
Owner 岳茂兴
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