Multi-mode ionization source and application thereof

An ionization source and multi-mode technology, applied in the direction of ion source/gun, circuit, discharge tube, etc., can solve the problems of poor ionization ability of non-polar or weak polar compounds, low analytical sensitivity, and inability to obtain molecular data, etc. Achieve the effects of small size, fast analysis speed, and avoid the process of disassembly and replacement

Active Publication Date: 2017-09-12
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The ionization source characterized by solution electrospray generally has a good analysis effect on polar compounds, but has poor ionization ability on non-polar or weakly polar compounds, and requires the analyte to be (partially) dissolved in a protic solvent; based on The atmospheric pressure desorption ionization technique based on the principle of plasma discharge is only suitable for analyzing some weakly polar or nonpolar small molecular compounds (<1000Da), and the analytical sensitivity of some polar compounds is lower than that of conventional electrospray ionization mass spectrometry
For complex samples containing both polar and non-polar compounds, the traditional single ionization source analysis cannot obtain complete molecular data, and the composite ionization source can often obtain rich information, but the interference and competition between ionization sources cannot be avoided Signal attenuation due to ionization

Method used

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  • Multi-mode ionization source and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0102] Using non-polar saturated alkanes as analytes, mass spectrometry was performed on the ionization source in the plasma ionization mode generated by glow discharge, where the structure of the ionization source was as follows Figure 4 As shown, the ion source is fixed on the three-dimensional adjustable platform, and the three-dimensional adjustable platform and the flowmeter are fixed on the metal plate suspended at the entrance of the mass spectrometer. The inlet of the mass spectrometer, and the linear distance from the inlet to the inlet is controlled at about 5mm. If it is too close, it will easily cause contamination of the inlet of the mass spectrometer, and if it is too far away, the signal will not be optimal. Specific sample analysis methods are as follows:

[0103] (1) the pentane solution of n-pentane and n-hexadecane to be analyzed (V C16H34 :V C5H12 =1:10), a syringe was used to inject 30 μL solution for mass spectrometry analysis, the syringe was connecte...

Embodiment 2

[0108] Using the ionization source of the embodiment of the present invention, in the plasma ionization mode generated by glow discharge, mass spectrometry analysis of complex samples can be performed. In this example, an ionization source is used to analyze complex samples such as paraffin oil. Paraffin oil is a non-polar alkane mixture, and the ESI source standard equipped with the LTQ XL mass spectrometer cannot detect its mass spectrum signal. Utilize the ionization source of embodiment 1 to analyze it, the analysis method is the same as embodiment 1, the main difference lies in the sample processing, in the present embodiment, paraffin oil is dissolved in n-hexane, the supernatant is taken, directly injects the sample, waits When the solution enters the discharge area, the corresponding mass spectrum peak can be detected, and the mass spectrum is as follows Figure 7 (Positive ion mode) shows that m / z 99 and 117 are the oxidation peaks of the solvent n-hexane, and the pea...

Embodiment 3

[0110] In this embodiment, two modes (i.e., electrospray ionization and glow discharge plasma ionization) in the ionization source of the embodiment of the present invention were respectively adopted to carry out mass spectrometry analysis on saturated hexadecanoic acid (palmitic acid). The process is as follows:

[0111] (1) Palmitic acid is dissolved in acetone, and the concentration is about (10 -5 The solution of M) was injected through a syringe pump, and the flow rate of the syringe pump was 3 μL / min.

[0112] (2) The external electrode is grounded, the internal electrode is applied with a high voltage of 2500V, a glow discharge occurs between the two metal tubes, the sample is ionized by plasma, and the mass spectrum obtained is recorded ( Figure 8 a, negative ion mode), see Example 1 for specific operations

[0113] (3) Change the power-on mode, remove the grounded wire, connect the high-voltage wire to the needle of the syringe, analyze the same palmitic acid sampl...

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Abstract

The invention discloses a multi-mode ionization source, a multi-mode ionization source system, a mass spectrum, and a method for analyzing a to-be-tested sample with the mass spectrum. The multi-mode ionization source comprises a capillary tube, an internal electrode, an insulating tube, an external electrode, a tee fitting, an insulating sleeve, a metal ring, a conductive member and a regulating member, wherein the outlet of the internal electrode in the axial direction is located between the insulating tube and the outlet of the outer electrode. The multi-mode ionization source can be easily switched between two modes of electrospray ionization and plasma ionization, which can effectively improve the efficiency of analysis and detection, avoid the complicated dismounting process of the ionization source and realize the highly sensitive detection of components in the complex sample. The multi-mode ionization source is especially suitable for a variety of polar and non-polar small molecule compounds.

Description

technical field [0001] The invention relates to a multi-mode ionization source and its application, in particular to a multi-mode ionization source, a multi-mode ionization source system, a mass spectrometer, and a method for analyzing samples to be measured by using the mass spectrometer. Background technique [0002] Atmospheric desorption ionization mass spectrometry (Ambient mass spectrometry) can directly ionize the sample rapidly under atmospheric pressure (the sample can be subjected to no pretreatment or minimal pretreatment), so as to achieve high-throughput and high-specificity mass spectrometry or quantitative analysis. In recent years, atmospheric pressure desorption ionization mass spectrometry has attracted wide attention. At present, dozens of atmospheric pressure desorption ionization techniques and multi-ionization source coupling techniques have been developed. These techniques are now widely used in food safety, drug analysis, and environmental analysis. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/10G01N27/68
CPCG01N27/68H01J49/107
Inventor 王继云占铃鹏聂宗秀谢小波王振鹏熊彩侨
Owner INST OF CHEM CHINESE ACAD OF SCI
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