Multi-mode ionization source and application thereof
An ionization source and multi-mode technology, applied in the direction of ion source/gun, circuit, discharge tube, etc., can solve the problems of poor ionization ability of non-polar or weak polar compounds, low analytical sensitivity, and inability to obtain molecular data, etc. Achieve the effects of small size, fast analysis speed, and avoid the process of disassembly and replacement
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Embodiment 1
[0102] Using non-polar saturated alkanes as analytes, mass spectrometry was performed on the ionization source in the plasma ionization mode generated by glow discharge, where the structure of the ionization source was as follows Figure 4 As shown, the ion source is fixed on the three-dimensional adjustable platform, and the three-dimensional adjustable platform and the flowmeter are fixed on the metal plate suspended at the entrance of the mass spectrometer. The inlet of the mass spectrometer, and the linear distance from the inlet to the inlet is controlled at about 5mm. If it is too close, it will easily cause contamination of the inlet of the mass spectrometer, and if it is too far away, the signal will not be optimal. Specific sample analysis methods are as follows:
[0103] (1) the pentane solution of n-pentane and n-hexadecane to be analyzed (V C16H34 :V C5H12 =1:10), a syringe was used to inject 30 μL solution for mass spectrometry analysis, the syringe was connecte...
Embodiment 2
[0108] Using the ionization source of the embodiment of the present invention, in the plasma ionization mode generated by glow discharge, mass spectrometry analysis of complex samples can be performed. In this example, an ionization source is used to analyze complex samples such as paraffin oil. Paraffin oil is a non-polar alkane mixture, and the ESI source standard equipped with the LTQ XL mass spectrometer cannot detect its mass spectrum signal. Utilize the ionization source of embodiment 1 to analyze it, the analysis method is the same as embodiment 1, the main difference lies in the sample processing, in the present embodiment, paraffin oil is dissolved in n-hexane, the supernatant is taken, directly injects the sample, waits When the solution enters the discharge area, the corresponding mass spectrum peak can be detected, and the mass spectrum is as follows Figure 7 (Positive ion mode) shows that m / z 99 and 117 are the oxidation peaks of the solvent n-hexane, and the pea...
Embodiment 3
[0110] In this embodiment, two modes (i.e., electrospray ionization and glow discharge plasma ionization) in the ionization source of the embodiment of the present invention were respectively adopted to carry out mass spectrometry analysis on saturated hexadecanoic acid (palmitic acid). The process is as follows:
[0111] (1) Palmitic acid is dissolved in acetone, and the concentration is about (10 -5 The solution of M) was injected through a syringe pump, and the flow rate of the syringe pump was 3 μL / min.
[0112] (2) The external electrode is grounded, the internal electrode is applied with a high voltage of 2500V, a glow discharge occurs between the two metal tubes, the sample is ionized by plasma, and the mass spectrum obtained is recorded ( Figure 8 a, negative ion mode), see Example 1 for specific operations
[0113] (3) Change the power-on mode, remove the grounded wire, connect the high-voltage wire to the needle of the syringe, analyze the same palmitic acid sampl...
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