Stress activity fiber film and preparation method thereof

A technology of active fibers and fiber membranes, applied in the field of biomedical materials, to achieve the effects of promoting functional coordination, ensuring biocompatibility, good piezoelectric effect and biocompatibility

Inactive Publication Date: 2017-09-15
WUHAN HUMANWELL MEDICAL SUPPLIES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned existing problems, the purpose of the present invention is to solve the defects existing in existing biological materials in tissue engineering scaffold materials and wound or scar repair materials, and to obtain polyvinylidene fluoride with piezoelectric properties β crystal phase by electrospinning polyvinylidene fluoride. Vinylidene fluoride nanofibers, electrospun polyvinylidene fluoride fibers and composite nanof

Method used

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  • Stress activity fiber film and preparation method thereof

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preparation example Construction

[0027] A method for preparing a stress-activated fiber membrane, comprising preparing a silk fibroin solution or a silk fibroin powder dispersion, a medical polymer synthetic material solution, and a polyvinylidene fluoride solution, characterized in that: the stress-activated The preparation method of sex fiber film is carried out as follows:

[0028]a. Take the prepared silk fibroin solution or silk fibroin powder dispersion with a diameter less than 500nm and mix it with the medical polymer synthetic material solution to obtain a uniform and stable mixed solution or suspension, and suck it into the electrospinning machine Spinning liquid tube, wherein the mass ratio of silk fibroin and medical polymer synthetic material is 1 / 20~1 / 1, the total solute mass concentration of silk fibroin and medical polymer synthetic material is 7wt%~15wt%, take configuration A good concentration is 7wt%-15wt% polyvinylidene fluoride solution sucked into another spinning solution tube for elect...

Embodiment 1

[0039] a. taking hexafluoroisopropanol as a solvent and a silk fibroin solution with a mass concentration of 5wt%, and N,N-dimethylformamide as a solvent with a mass concentration of 20% polyurethane (PU) solution to mix to obtain silk fibroin The mass ratio with the medical polymer synthetic material polyurethane (PU) is 1 / 20, the total solute mass concentration of silk fibroin and the medical polymer synthetic material polyurethane (PU) is a mixed solution of 7wt%, and the mixed solution is sucked into the electrospinning The spinning liquid tube used is to suck the polyvinylidene fluoride solution with N,N-dimethylformamide as the solvent concentration of 7wt% into the spinning liquid tube for electrospinning.

[0040] b. Build the electrospinning device, use the rotating roller as the collection plate, and place two sets of electrospinning push pumps and corresponding high-voltage power supplies on the left and right sides of the rotating roller and on the reciprocating mov...

Embodiment 2

[0044] a. with hexafluoroisopropanol as a solvent, a mass concentration of 10wt% silk fibroin solution, and dimethylacetamide as a solvent mass concentration of 10wt% polycaprolactone (PCL) solution mixed to obtain silk fibroin and The mass ratio of medical polymer synthetic material polycaprolactone (PCL) is 1 / 10, and the total solute mass concentration of silk fibroin and medical polymer synthetic material polycaprolactone (PCL) is a mixed solution of 10wt%, and The mixed solution was sucked into the spinning liquid pipe for electrospinning, and the polyvinylidene fluoride solution with dimethylacetamide as the solvent concentration of 10 wt% was sucked into the spinning liquid pipe for electrospinning.

[0045] b. Build the electrospinning device, use the rotating roller as the collection plate, and place two sets of electrospinning push pumps and corresponding high-voltage power supplies on the left and right sides of the rotating roller and on the reciprocating moving tabl...

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Abstract

The present invention relates to a stress activity fiber film and a preparation method thereof, and belongs to the field of biomedical materials, wherein the stress activity fiber film comprises polyvinylidene fluoride nanometer fiber and composite nanometer fiber, the composite nanometer fiber comprises silk fibroin and a medical polymer synthesis material, a mass ratio of the silk fibroin to the medical polymer synthesis material in the stress activity fiber film is 1/20-1/1, a mass ratio of the polyvinylidene fluoride to the medical polymer synthesis material is 1/99-5/95, and by using the mixed solution of an electrospinning silk fibroin solution or a silk fibroin powder dispersion solution and a medical polymer synthesis material solution and a polyvinylidene fluoride solution, the interpenetrating nonwoven structure fiber film comprising the composite nanometer fiber (comprising the silk fibroin and the medical polymer synthesis material) and the polyvinylidene fluoride nanometer fiber is obtained. According to the present invention, the fiber film has characteristics of uniform and stable micro-structure and good biocompatibility, and can be widely used in tissue engineering scaffolds and wound or scar repair materials, wherein the fiber film is endowed with the stress activity due to the good piezoelectricity of the polyvinylidene fluoride nanometer fiber.

Description

technical field [0001] The invention relates to a stress-activated fiber membrane and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Responsiveness generally refers to the general term for the characteristics of organisms responding to external stimuli and transforming or transmitting such stimuli. Fibrous membranes have been widely used in tissue engineering scaffolds for tissue repair in vivo and wound or scar care on the body surface. However, the current tissue engineering scaffolds used for in vivo tissue repair are limited to space-occupying replacement repair or space-occupying reconstruction, which provide physical space and matrix environment for tissue growth, and cannot respond to physiological loads, electromagnetic effects, Physical stretching, compression or biochemical stimuli make the corresponding response activation, and the fibrous membrane used for wound or scar care on the body surface is also...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/56A61L27/16A61L27/22A61L27/18A61L31/14A61L31/04A61L31/06
Inventor 柏自奎周应山向春彭国富龚年华郭强
Owner WUHAN HUMANWELL MEDICAL SUPPLIES
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