Stress activity fiber film and preparation method thereof

Abstract

The present invention relates to a stress activity fiber film and a preparation method thereof, and belongs to the field of biomedical materials, wherein the stress activity fiber film comprises polyvinylidene fluoride nanometer fiber and composite nanometer fiber, the composite nanometer fiber comprises silk fibroin and a medical polymer synthesis material, a mass ratio of the silk fibroin to the medical polymer synthesis material in the stress activity fiber film is 1 / 20-1 / 1, a mass ratio of the polyvinylidene fluoride to the medical polymer synthesis material is 1 / 99-5 / 95, and by using the mixed solution of an electrospinning silk fibroin solution or a silk fibroin powder dispersion solution and a medical polymer synthesis material solution and a polyvinylidene fluoride solution, the interpenetrating nonwoven structure fiber film comprising the composite nanometer fiber (comprising the silk fibroin and the medical polymer synthesis material) and the polyvinylidene fluoride nanometer fiber is obtained. According to the present invention, the fiber film has characteristics of uniform and stable micro-structure and good biocompatibility, and can be widely used in tissue engineering scaffolds and wound or scar repair materials, wherein the fiber film is endowed with the stress activity due to the good piezoelectricity of the polyvinylidene fluoride nanometer fiber.

Description

technical field [0001] The invention relates to a stress-activated fiber membrane and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Responsiveness generally refers to the general term for the characteristics of organisms responding to external stimuli and transforming or transmitting such stimuli. Fibrous membranes have been widely used in tissue engineering scaffolds for tissue repair in vivo and wound or scar care on the body surface. However, the current tissue engineering scaffolds used for in vivo tissue repair are limited to space-occupying replacement repair or space-occupying reconstruction, which provide physical space and matrix environment for tissue growth, and cannot respond to physiological loads, electromagnetic effects, Physical stretching, compression or biochemical stimuli make the corresponding response activation, and the fibrous membrane used for wound or scar care on the body surface is also...

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Problems solved by technology

[0005] In view of the above-mentioned existing problems, the purpose of the present invention is to solve the defects existing in existing biological materials in tissue engineering scaffold materials and wound or scar repair materials, and to obtain polyvinylidene fluoride with piezoelectric properties β crystal phase by electrospinning polyvinylidene fluoride. Vinylidene fluoride nanofibers, electrospun polyvinylidene fluoride fibers and composite nanofibers of electrospun silk fibroin and medical polymer synthetic materials on the same collection roller at the same time, to obtain silk fibroin and medical polymer synthetic materials The interpenetrating non-woven structure composed of composite nanofibers and polyvinylidene fluoride nanofibers has a piezoelectric and active fiber membrane. This fiber membrane can be widely used in tissue engineering scaffold materials and wound or scar repair materials.

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