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Corn bran starch hollow capsule and preparation method thereof

A technology of corn bran and hollow capsules, which is applied in the direction of capsule transportation, etc., can solve the problems of affecting the market competitiveness of starch hollow capsules, restricting the market application of starch hollow capsules, and the unsafe feeling of gelatin raw materials, so as to facilitate market promotion, Excellent water retention, the effect of improving cost advantages

Inactive Publication Date: 2017-09-22
中象新材料(大连)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the vast majority of medical empty capsules use gelatin as raw material. Gelatin is made by boiling and hydrolyzing animal bones, skins, and tendons. Gelatin raw materials have created a sense of insecurity, especially after entering the 21st century, some lawbreakers have been exposed in my country, and illegal use of industrial gelatin with heavy metals exceeding the standard to replace pharmaceutical gelatin to prepare empty capsules pushes this insecurity. reached the top
[0003] In recent years, starch as an alternative material has become a key research object in the field of capsules, but due to its insufficient mechanical properties and the shortcomings of easy drying, dehydration and embrittlement, the market application of starch hollow capsules is limited.
For this reason, various functional materials must be added, such as hydroxypropyl methylcellulose ether, carboxymethylcellulose ether, hydroxyethyl cellulose ether, hydroxyethyl methylcellulose ether, to make up for the above-mentioned shortcomings of starch, It’s just that hydroxypropyl methylcellulose ether, carboxymethyl cellulose ether, hydroxyethyl cellulose ether, and hydroxyethyl methylcellulose ether use cotton as raw material, which is expensive and seriously affects the market competitiveness of starch hollow capsules.

Method used

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  • Corn bran starch hollow capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of corn bran carboxymethyl cellulose ether: In a 50L reaction kettle, add 25L of 92% ethanol, add 3.5kg of sodium hydroxide under stirring, heat to 70°C for 30 minutes, cool to 35°C and add 5kg of corn bran powder, alkalized for 0.5 hour, vacuumed to -0.05Mpa, and pumped for 10 minutes. Add 7.85kg of 50% chloroacetic acid ethanol solution, start to heat up, rise to 55°C in 30 minutes, react for 30 minutes, rise to 78°C in 15 minutes, and react for 2 hours. Cool to 45°C, centrifuge and wash to obtain 5.2kg corn bran carboxymethyl cellulose ether.

[0034] (2) Preparation of hollow capsules: the formula of the raw material combination is as follows:

[0035] raw material

[0036] According to the above formula, adopt spraying or granulation process to make a raw material combination, add 4 times the mass of water, stir evenly, heat to 80°C to completely dissolve and gelatinize, and form a glue, then cool down to 50°C, 50°C Under a constant temp...

Embodiment 2

[0038] According to the formula of Example 1, investigate the improvement effect of the amount of corn bran carboxymethyl cellulose ether on the friability, according to "Chinese Pharmacopoeia" 2015 edition, carry out the detection of friability, the test results are shown in the following table:

[0039]

[0040] Note: Use corn starch to make up the difference between the amount of corn bran carboxymethyl cellulose ether.

Embodiment 3

[0042] (3) Preparation of corn bran hydroxypropyl cellulose ether: In a 50L reactor, add 25L of 92% isopropanol, add 3.5kg of sodium hydroxide under stirring, heat to 70°C for 30 minutes, cool to 35°C Add 5kg corn bran powder at ℃, alkalinize for 0.5 hour, vacuumize to -0.05Mpa, and pump for 10 minutes. Add 1.8kg of propylene oxide, stir and react at room temperature for 20 minutes, heat up to 45-55°C, react for 2 hours, cool to 25°C, centrifuge, wash to obtain 5.5kg of corn bran hydroxypropyl cellulose ether.

[0043] (4) Preparation of hollow capsules: the raw material formula is as follows:

[0044] raw material

[0045] According to the above formula, adopt spraying or granulation process to make a raw material combination, then add 5 times the mass of water, stir evenly, heat to 70°C to completely dissolve and gelatinize, and form a glue, then cool down to 40°C, 40°C ℃ in a constant temperature water bath, let it stand for 2.5 hours, and the defoaming is comple...

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Abstract

A corn bran starch hollow capsule and a preparation method thereof belong to the field of medicinal edible hollow capsules. According to the preparation method of the corn bran starch hollow capsule, corn bran cellulose ether is blended with a variety of raw starches or modified starches, gelatinizer, plasticizer, opacifier and coloring agent and treated through spraying or pelletizing processes to obtain the raw material composition of the starch hollow capsule; the raw material composition is dissolved and heated in water into a gelatin solution to obtain the corn bran starch empty capsule. By means of the corn bran cellulose ether, the prepared corn bran starch empty capsule is excellent in water-retaining property and friability.

Description

technical field [0001] The invention relates to a hollow corn bran starch capsule and a preparation method thereof, belonging to the field of medical edible hollow capsules. Background technique [0002] At present, the vast majority of medical empty capsules use gelatin as raw material. Gelatin is made by boiling and hydrolyzing animal bones, skins, and tendons. Gelatin raw materials have created a sense of insecurity, especially after entering the 21st century, some lawbreakers have been exposed in my country, and illegal use of industrial gelatin with heavy metals exceeding the standard to replace pharmaceutical gelatin to prepare empty capsules pushes this insecurity. to the top. [0003] In recent years, starch as an alternative material has become a key research object in the field of capsules, but due to its insufficient mechanical properties and the shortcomings of easy drying, dehydration and embrittlement, the market application of starch hollow capsules is limited....

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/38
CPCA61K9/4816A61K47/36A61K47/38
Inventor 冯有愉夏盛钦冯麒合冯超
Owner 中象新材料(大连)有限公司
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