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Novel liquid embolization material and preparing method thereof

A liquid and embolization technology, used in medical science, surgery, etc., can solve the problems of "sticky tubes, inability to tightly adhere to the walls of diseased blood vessels, etc., and achieve the effects of increasing density, dense embolization, and improving development efficiency.

Inactive Publication Date: 2017-09-22
向建平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Liquid embolic materials in the prior art include: (1) adhesive liquid embolic material n-butyl cyanoacrylate viscous material, which has the disadvantage of being prone to "pipe sticking"; (2) non-adhesive liquid embolic material, mainly Onyx glue, etc., its disadvantages include the nature of onyx glue itself so that it cannot be tightly bonded to the diseased vessel wall
Moreover, neither of these two types of materials can embolize microvascular aneurysms and vascular malformations where complex microcatheters are difficult to fully place.

Method used

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  • Novel liquid embolization material and preparing method thereof
  • Novel liquid embolization material and preparing method thereof
  • Novel liquid embolization material and preparing method thereof

Examples

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preparation example Construction

[0029] agarose-coated Fe 3 o 4 Methods for the preparation of nanoparticles.

[0030] see figure 2 , figure 2 is agarose-coated Fe 3 o 4 Flowchart of the preparation of nanoparticles. First execute step S1, 400 grams of FeCl 3 ·6H 2 O was dissolved in a glass reaction vial containing 2 L of ethylene glycol under ultrasonic conditions; then step S2 was performed, and 40 g of agarose and 200 g of NH were added thereto at a temperature of 160 °C 4 Ac, stir for 1 hour to obtain a mixed solution; then perform step S3, transfer the mixed solution to an autoclave equipped with polytetrafluoroethylene; further perform step S4, at 2atm (standard atmospheric pressure) to 3atm, 200 ° C temperature conditions React for 12 hours; cool to room temperature after the reaction to obtain a black product; then perform step S5, repeatedly wash the black product with ethanol and water several times, then collect the black product through a magnetic field; finally perform step S6, and col...

Embodiment 1

[0032] see image 3 , image 3 It is the preparation flowchart of the liquid embolism material of embodiment one. First perform step S11, take 100 grams of the above-mentioned black powder and 8 grams of EVOH polymer and disperse them in 100 ml of dimethyl sulfoxide solvent under ultrasonic conditions; then perform step S12, mechanically stir for 2 hours to obtain a liquid embolism material, the Liquid embolization material contains a large amount of Fe encapsulated in agarose 3 o 4 Nano-composite particles with nanoparticles as the core and EVOH polymer as the shell. This liquid embolic material is low viscous, with a viscosity value around 30 centipoise.

[0033] see Figure 4 , Figure 4 It is a schematic diagram of the embolization of the liquid embolic material in the AVM of this embodiment. In this embodiment, after the liquid embolic material 100 is injected into the arteries of the AVM 100 through the microcatheter 110, due to the low viscosity and strong penetr...

Embodiment 2

[0035] see Figure 5 , Figure 5 It is the preparation flowchart of the liquid embolic material of embodiment two. First perform step S21, take 100 grams of the above-mentioned black powder and 20 grams of EVOH polymer and disperse them in 100 ml of dimethyl sulfoxide solvent under ultrasonic conditions; then perform step S22, mechanically stir for 2 hours to obtain a liquid embolism material, the Liquid embolization material contains a large amount of Fe encapsulated in agarose 3 o 4 Nano-composite particles with nanoparticles as the core and EVOH polymer as the shell. This liquid embolic material is highly viscous, with a viscosity value of up to 1000 centipoise.

[0036] see Image 6 , Image 6 It is a schematic diagram of the embolization of the liquid embolism material in the cerebral aneurysm in this embodiment. In this embodiment, the liquid embolic material 200 is injected into the position of the cerebral aneurysm 240 from the blood vessel 230 through the micro...

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Abstract

The invention provides a novel liquid embolic material and a preparation method thereof. The liquid embolic material comprises Fe3O4 nanoparticles wrapped in agarose, EVOH polymers and a dispersant, and the EVOH polymer is wrapped on the surface of the Fe3O4 nanoparticles wrapped in agarose to form agarose The sugar-wrapped Fe3O4 nanoparticles are the core and the EVOH polymer is the shell of the nanocomposite particles, and the nanocomposite particles are dispersed in the dispersant. Utilizing the superparamagnetic effect of Fe3O4 nanoparticles, the liquid embolic material can be targeted and positioned under the guidance of an external magnetic field, and it can embolize complex microvascular aneurysms and complex microvascular aneurysms that are difficult to fully place with microcatheters. of vascular malformations.

Description

technical field [0001] The invention relates to a medical liquid composition, in particular to a liquid embolism material and a preparation method thereof. Background technique [0002] A localized weak bulge in the wall of an intracranial artery forms a so-called cerebral aneurysm, much like the bulge on a well-worn bicycle inner tube. The causes of brain aneurysms are not fully understood, and inherited weakness of the artery walls may be a factor in the formation of aneurysms. The incidence of aneurysms in children has been clinically observed to be very low, and most aneurysms may be caused by the continuous wear and tear of the arterial wall with age. Sometimes severe head trauma or infection can also cause an aneurysm to form. According to the latest understanding, the formation of aneurysms is closely related to the hemodynamics in cerebral vessels, and potential risk factors also promote the formation of aneurysms, including smoking and high blood pressure. Statis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/02A61L31/04A61L31/18
CPCA61L31/14A61L31/028A61L31/042A61L31/048A61L31/18
Inventor 向建平
Owner 向建平
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