A kind of preparation method of panaxadiol saponin and panaxadiol type saponin monomer
A technology of panaxadiol saponins and ginsenosides is applied in the preparation of steroids, the preparation of sugar derivatives, chemical instruments and methods, etc., and can solve the problems of strong dead adsorption, high cost of fillers, poor selectivity, etc., and achieves high separation, high The effect of large adsorption capacity and large loading capacity
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Embodiment 1
[0024] Embodiment 1: The preparation method of this Panaxadiol Saponin is as follows:
[0025] (1) After the American ginseng was crushed to 60 mesh, an ethanol solution with a concentration of 60% of crude drug mass 7 times the mass was added to the raw material and extracted by cold soaking at room temperature for 12 hours. % ethanol solution for extraction for 12 hours, and after filtration, add 3 times the mass percentage of the crude drug to the residue in an ethanol solution with a concentration of 60% for extraction for 12 hours; combine the three extracts and concentrate under reduced pressure at 60°C to recover the solvent, and dilute the concentrated solution to 5 times the crude drug with purified water Diatomaceous earth filter after measuring, collect filtrate;
[0026] (2) Pass the filtrate of step (1) through a macroporous adsorption resin (ZGCAD45) column with a pore size of 50-60 μm to adsorb ginseng triol saponins, collect the effluent from the upper column, ...
Embodiment 2
[0030] Embodiment 2: the preparation method of this Panaxadiol Saponin is as follows:
[0031](1) After ginseng is used as the raw material and crushed to 60 mesh, an ethanol solution with a concentration of 8 times the mass percentage of the crude drug is added to the raw material and extracted by cold soaking at room temperature for 12 hours. % ethanol solution for extraction for 12 hours, after filtration, add 4 times the mass percentage of the crude drug to the residue in an ethanol solution with a concentration of 70% for extraction for 12 hours; combine the 3 extracts and concentrate under reduced pressure at 60°C to recover the solvent, and dilute the concentrated solution to 4 times the crude drug with purified water Diatomaceous earth filter after measuring, collect filtrate;
[0032] (2) Pass the filtrate of step (1) through a 50-65 μm pore size macroporous adsorption resin (IIZ-803) column to adsorb ginseng triol saponins, collect the effluent from the upper column,...
Embodiment 3
[0036] Embodiment 3: the preparation method of ginseng diol type saponin monomer is as follows:
[0037] (1) After taking Panax notoginseng as the raw material and crushing it to 60 mesh, add an ethanol solution with a concentration of 75% of the mass percentage of the crude drug to 7.5 times the mass percentage of the raw material, cold soak and extract at room temperature for 12 hours, and add a concentration of 5.5 times the mass percentage of the crude drug mass to the filter residue after filtration Extract with 75% ethanol solution for 12 hours, add 3.5 times the mass percentage of crude drug to the filter residue to extract with 75% ethanol solution for 12 hours; combine 3 extracts and concentrate under reduced pressure to recover the solvent, and dilute the concentrated solution to 5 times the crude drug amount with purified water After diatomaceous earth filtration, collect filtrate;
[0038] (2) Pass the filtrate of step (1) through a macroporous adsorption resin (D4...
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