Electro-spinning jet directional coating device and process for preparing polymer tube through directional coating device

Abstract

The invention discloses an electro-spinning jet directional coating device and a process for preparing a polymer tube through the directional coating device. The device comprises a micro injection pump, a metal receiving device and a high-voltage power supply, wherein the micro injection pump is connected with an injector, the injector is connected with a metal jet nozzle through a polytetrafluoroethylene tube, an electric field shielding tube is arranged on the periphery of the metal jet nozzle, and the metal jet sprayer and the electric field shielding tube are connected with the same electrode of the high-voltage power supply through wires; the vertical distance between the metal receiving device and the tip of the metal jet nozzle is smaller than the vertical distance between a jet change portion and the top of the metal jet nozzle, and the metal receiving device is connected with a grounding wire of the high-voltage power supply. The tube prepared through the device is uniform in thickness and can be accurately controlled.

Description

technical field [0001] The invention relates to an electrospinning jet directional coating device and a process for preparing polymer pipes by using the directional coating device, belonging to the fields of medical biological materials and tissue engineering. Background technique [0002] Polymer tubing is widely used in the field of biomedicine, such as drainage tubes, nerve guides, etc., especially degradable medical polymer tubing, which can be degraded into physiologically inert small molecular compounds in the body, and then metabolized, absorbed or excreted by the body. When used in clinical applications such as implantable medical devices, drug slow and controlled release devices, tissue engineering scaffolds, etc., it will slowly degrade after implantation, without the need for secondary surgery to remove it, which can reduce the pain of patients and simplify treatment procedures. The clinical requirements of medical polymer tubing are relatively high, and the dimen...

AI Technical Summary

Problems solved by technology

However, the electrospinning jet is difficult to orientate the microfibrils to a specific part of the receiver due to the mutual repulsion of the charges and the whipping of the jet due to aerodynamic factors.

Chinese patent document CN 101363137 A discloses an electrospinning device for preparing aligned nanofibers, including a high-voltage power supply, a syringe, a syringe pump for pushing the syringe, and a collection device; the collection device is an open fiber collector, which is executed by The unit and the control unit are composed of two parts: the execution unit is an open drum, the control unit includes a drive motor and a speed controller, and the motor drives the drum to rotate through a coupling; the invention obtains oriented nanofibers through the high-speed rotation of the collecting device , but still affected by jet whipping, the degree of orientation needs to be improved

At present, electrospinning technology is also applied in the preparation of polymer tubes. For example, Chinese patent document CN 103432630 A discloses a preparation method of a double-network interwoven composite nerve conduit. The preparation method uses degradable chemical polymer materials as raw materials, Electrospinning equipment is used to make hollow fiber mesh tubes, which are then immersed in a hydrophilic biopolymer solution. After freeze-drying, pH value treatment, and drying, a double-network interwoven composite nerve guide is obtained; however, the tubes prepared by the method of the invention The thickness is not uniform, and the dimensions such as inner diameter and wall thickness are not easy to control, which has certain application limitations

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