Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Multifunctional ambient composite ion source and using method thereof

A composite ion and open technology, applied in the direction of ion source/gun, particle separation tube, particle separator tube parts, etc., can solve the problems of sample loss, unusable helium gas, narrowing of material range, etc., and achieve the goal of working Highly effective, effect that increases target range

Active Publication Date: 2017-09-22
PEKING UNIV
View PDF8 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The DEMI ion source has the following problems: 1. A long capillary used in the combined device is used as a sample transmission line. The design of this device has low ionization efficiency, which will cause a certain loss of samples; memory effects when compounding samples
The ESI / APCI ion source has the following problems: this type of ion source uses DESI nebulizer gas as a dielectric discharge gas at the same time, resulting in the unusable helium gas for mass spectrometry and narrowing the range of ionizable substances

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Multifunctional ambient composite ion source and using method thereof
  • Multifunctional ambient composite ion source and using method thereof
  • Multifunctional ambient composite ion source and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Using the single DESI ion source function of the present invention to detect three lipid molecules, PC, SM and LPC.

[0049] Specific steps are as follows:

[0050] (1) Device construction and experimental preparation. The measured substances are lipid molecules PC, SM and LPC, which are dissolved in methanol solution with a concentration of 1 mg / mL. Take 2-10μL samples and spot on the glass slide and place the glass slide in front of the entrance of the mass spectrometer. see figure 1 , the double-layer capillary 2 selected by the DESI ion source is a fused silica capillary, wherein the inner diameter of the inner tube 7 is 50 μm, and the inner diameter of the outer tube 8 is 250 μm. The incident angle of the electrospray generated by the DESI ion source is 50°, the front end of the ion source is 1 mm from the sample height, and the distance from the sample to the entrance of the mass spectrometer is 2 mm. The DESI electrospray voltage is set to 4000V, ...

Embodiment 2

[0053] Embodiment 2: Using the function of a single DBDI ion source in the present invention, combined with a vacuum pump to detect pesticide molecules under the assistance of a ring heater.

[0054] Specific steps are as follows:

[0055] (1) Device construction and experimental preparation. The substances to be detected were three pesticide molecules, namely atraton, diquat, and ametryn, which were dissolved in methanol solution at a concentration of 1 μg / mL. The sample is ionized by direct dipping. Such as Figure 5 Shown is a schematic diagram of the experimental device, wherein the tube dielectric layer 3 is a quartz tube with an inner diameter of 4 mm and a thickness of 1 mm, and the diameter of the needle electrode 1 is 0.8 mm. The ion source is placed horizontally and collinear with the mass spectrometer inlet 13 (the mass spectrometer inlet 13 is connected to the vacuum pump 12 to form a negative pressure), and the distance from the mass spectrometer inlet 13 is 2 ...

Embodiment 3

[0058] Embodiment 3: Using the function of a single DBDI / LTP ion source in the present invention, combined with laser desorption, to detect four molecules such as quinine under the assistance of a vacuum pump.

[0059] Specific steps are as follows:

[0060] (1) Device construction and experimental preparation. The detected substances were quinine, chloramphenicol, rhodamine B, and Sudan III, which were dissolved in methanol solution at a concentration of 3 mg / mL. Such as Figure 10 Shown is a schematic diagram of the experimental device, wherein the tube dielectric layer is a quartz tube with an inner diameter of 4 mm, a thickness of 1 mm, and a needle electrode diameter of 0.8 mm. Place the ion source horizontally and collinearly with the entrance of the mass spectrometer 13, the distance from the entrance of the mass spectrometer 13 is 2 cm, take 2-10 μL of sample and apply it on the TLC plate 16 and place the TLC plate 16 in front of the entrance of the mass spectrometer...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The inside diameter ofaaaaaaaaaa
Thicknessaaaaaaaaaa
Outer diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a multifunctional ambient composite ion source and a using method thereof. The purpose of realizing one-time high-throughput mixture detection is realized in an ambient mass spectrometry. The composite ion source comprises a pin electrode, a pipe electrode, a conductive ring-shaped electrode, a double-layer capillary pipe and a pipe dielectric layer, wherein the pin electrode and the pipe electrode form an electrode pair to be inserted in the pipe dielectric layer for realizing DART (analysis in real time) and other DC discharge ion sources; the conductive ring-shaped electrode is wound on the outer surface of the pipe dielectric layer, and together with the pin electrode, forms another electrode pair for realizing DBDI (dielectric barrier discharge ionization) and other AC discharge ion sources; and the double-layer capillary pipe is inserted in the pipe dielectric layer and extends from the other end to form a DESI (desorption electrospray ionization) ion source. A laser source can be added as an auxiliary device for desorption. Influences of memory effects are eliminated, helium and other high-energy gases with high ionization efficiency can be used, multiple ionization modes can be used alone and can be used compositely, and the multifunctional ambient composite ion source and the using method have the advantage of high-throughput detection.

Description

technical field [0001] The invention relates to a mass spectrometer open type ionization technology, in particular to a method for building and using a multifunctional open type composite ion source device. Background technique [0002] Open mass spectrometry (ambient mass spectrometry, AMS) technology is a technology that can directly ionize samples in an open laboratory environment. Samples can be analyzed directly with no or only simple pretreatment. Therefore, open mass spectrometry simplifies the workflow and improves the usability of mass spectrometry instruments. Since the advent of the two most typical ionization techniques: desorption electrospray ionization (DESI) and real-time direct analysis (analysis in real time, DART), a variety of ionization techniques have emerged, such as , dielectric barrier discharge ionization (dielectric barrier discharge ionization, DBDI), low temperature plasma (low temperature plasma, LTP), flowing atmospheric pressure afterglow di...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): H01J49/10G01N27/62G01N27/68
CPCG01N27/62G01N27/68H01J49/107
Inventor 白玉艾万鹏刘虎威聂洪港
Owner PEKING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com