Borane compound that can be used for antibacterial therapy and its preparation method

A technology of borane compound and dodecaborane, which is applied in the field of borane compound and its preparation, can solve limitations and other problems, and achieve the effects of short synthesis path, sensitive drug-resistant bacteria, and mild reaction conditions
CN107266486BActive Publication Date: 2019-04-02ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2019-04-02

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Abstract

The invention provides a borane compound used for antibacterial treatment. The borane compound is a dodecaborane substituted amide or a dodecaborane-oxazole. The preparation method comprises: (1) taking a mono-aminated dodecaborane as a raw material and performing an acylation reaction with an acyl chloride compound under the effect of sodium hydride to obtain a dodecaborane substituted amide; and (2) performing oxidative coupling on the dodecaborane substituted amide obtained in the step (1) under the effect of (diacetoxyiodo)benzene to obtain a dodecaborane-oxazole. The invention also provides an application of the borane compound in preparing antibacterial agents. The borane compound has extremely high antibacterial activity on certain Gram negative bacteria, and has a huge prospect.
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Description

Technical field

[0001] The invention relates to the field of antibacterial drugs, in particular to a borane compound that can be used for antibacterial therapy and a preparation method thereof. Background technique

[0002] In recent decades, the emergence and spread of antibiotic-resistant pathogens has accelerated, resulting in a rapid increase in the level of antibiotic resistance. At present, antibiotic resistance of pathogens has become a global public health problem. Therefore, it is very necessary to develop new types of antibacterial compounds. To this end, the World Health Organization (WHO) has listed a global priority list of antibiotic-resistant pathogens to guide the priority development of new antibiotics and effective antibiotic treatments to solve the urgent problem of antibiotic-resistant pathogens.

[0003] In recent years, a large number of studies have evaluated the antibacterial activity of existing antibacterial drug derivatives, such as the new fluoroketola...

Claims

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