5results about How to "Short synthesis path" patented technology

The invention relates to the field of fluorescent dyes, in particular to a near-infrared fluorescent dye for brain imaging as well as a preparation method and application of the near-infrared fluorescent dye. The near-infrared fluorescent dye for brain imaging has the advantages of novel structure, good biocompatibility, large Stokes shift, high light stability, high fluorescence signal-to-noise ratio and the like; the near-infrared fluorescent dye prepared by the invention is simple in preparation process, mild in reaction condition, short in synthesis path and beneficial to industrial production, and has a wide application prospect.

The invention belongs to the technical field of flow batteries, and relates to an electrolyte containing a polyanionic electrolyte additive and a flow battery. Comprising a viologen compound, a supporting electrolyte, a solvent and a polyanionic electrolyte additive, the polyanionic electrolyte additive accounts for 0.1%-20% of the electrolyte in percentage by mass; molecules of the polyanionic electrolyte additive are rich in various functional groups with negative charges, and the polyanionic electrolyte additive is used for interfering the pi-pi accumulation behavior of viologen molecules; the polyanionic electrolyte additive is a polymer containing a repetitive unit, and is sodium polystyrenesulfonate, sodium polyacrylate, poly (2-acrylamido-2-methyl sodium propanesulfonate) or sodium alginate. By introducing a polymer carrying high-density negative charges in the structure or aggregated inorganic anions, multiple regulation and control effects on viologen molecules in a water-phase environment are realized, aggregation behaviors of reduced molecules of the viologen molecules are remarkably inhibited, and chemical and electrochemical stability of the electrolyte is improved.

The invention relates to a glutathione probe, a preparation method and application thereof, and a bifunctional glutathione probe, which consumes bimolecular glutathione through a sequential activation strategy, so that high fluorescence enhancement is realized, and the accuracy of glutathione response imaging is realized. The Cy-ResNPs shows selective accumulation in mitochondria, the level of reactive oxygen species (ROS) is effectively improved by consuming glutathione, including induction of superoxide anions, and efficient photodynamic therapy is achieved. Intracellular oxidative stress storms induced by a variety of pathways promote iron apoptosis, cell apoptosis, and lethal toxicity in cancer cells. Finally, the Cy-ResNPs realizes accurate diagnosis and effective treatment in transplantable and rapid proliferative melanoma tumors. The research has important significance for tumor therapeutic research by consuming the intelligent small molecular fluorescent agent of glutathione in the future.

This invention belongs to the field of medicinal chemistry, specifically relating to a method for synthesizing ivcarboxylate. The specific technical solution includes: a method for synthesizing ivcarboxylate, comprising: reductive amination of a chiral amine with a benzyl-protected nitrogen atom with a pyrrolidone, followed by catalytic hydrogenation to remove the protecting group, thereby obtaining ivcarboxylate. The preparation method provided by this invention has a short synthetic route, relatively mild preparation conditions, and great application potential.

The invention discloses a beta amyloid protein probe and a preparation method and application thereof.A skeleton of the beta amyloid protein probe can effectively improve the ICT effect of the probe, so that the probe has larger emission wavelength and has larger fluorescence intensity enhancement multiple before and after being combined with A beta protein, and meanwhile, the fluorescence intensity enhancement multiple is larger after being combined with A beta protein. A nitrogen-containing six-membered aromatic ring is used as an electron acceptor, so that the probe has better electron-withdrawing capability, large steric hindrance of the electron acceptor can enhance limitation on molecular torsion after the probe enters a hydrophobic cavity of A beta protein, a more efficient ICT effect is triggered by the probe and a thiophene-containing pi bridge, and meanwhile, the probe can be used for detecting the A beta protein. The nitrogen-containing six-membered aromatic ring can be well combined with a beta-shaped sheet structure of the A beta protein, and the combining capacity of the probe and the A beta protein and the selectivity of the A beta protein are effectively improved, so that the probe can be applied to marking of the A beta protein and preparation of imaging agents for marking the A beta protein.