33results about How to "Short synthesis path" patented technology

The invention discloses a nitrogen-containing organic phosphorous acid corrosion inhibitor and a synthesis method thereof. The structural formula of the nitrogen-containing organic phosphorous acid corrosion inhibitor is shown by the formula I and the formula II; and the synthesis method of this type of compound comprises the following steps that aldehyde / ketone, melamine, hypophosphorous acid and hypophosphite are subjected to Mancini reaction to produce corresponding nitrogen-containing organic phosphonic acid, nitrogen-containing organic phosphonic acid is used as the acid corrosion inhibitor of carbon steel, galvanized steel and stainless steel, the dosage is 20-500 mg / L, the pH value of a corrosive medium is 0-7, the using temperature is 10-280DEG C, and metal materials can be protected effectively. The synthesis method of the nitrogen-containing organic phosphorous acid corrosion inhibitor has the following advantages that raw materials are easy to get, the price is low, the reaction condition is mild, the synthetic path is short, and the affect on environmental ecology is small.

The invention discloses a preparation method of 4-(tert-butyl 1-piperazinecarboxylate-4-yl)aniline. The preparation method of the 4-(tert-butyl 1-piperazinecarboxylate-4-yl)aniline comprises the following steps that aniline, piperazine-1-tert-butyl formate and acridine salt photocatalysts are added into a solvent; illumination reaction is performed under the condition of oxidizing agent existence;the 4-(tert-butyl 1-piperazinecarboxylate-4-yl)aniline is generated. The preparation method of the 4-(tert-butyl 1-piperazinecarboxylate-4-yl)aniline has the advantages that the 4-(tert-butyl 1-piperazinecarboxylate-4-yl)aniline is synthesized in one step; on one hand, the synthesis path of the 4-(tert-butyl 1-piperazinecarboxylate-4-yl)aniline is effectively shortened; the generation of by-products is effectively reduced; the target product yield is improved; on the other hand, only photocatalysts and oxidizing agents are used, so that the preparation method is safe and achieves an environment-friendly effect; the cost is low.

The invention discloses a method for preparing a floriform metal fluoride nano material. The method comprises the following steps: 1) calcining a carbon nitride compound so as to obtain g-C3N4; 2) performing ultrasonic dispersion on g-C3N4 into an alcohol solvent so as to obtain a g-C3N4 dispersion; 3) adding a metal salt into the g-C3N4 dispersion, performing uniform mixing, further adding hydrofluoric acid, and performing uniform mixing so as to obtain a mixed solution; and 4) adding the mixed solution into a reaction kettle, performing a solvothermal reaction, further filtering the reactionliquid, and performing washing and drying on a solid obtained through filtration. The method disclosed by the invention can be adopted to prepare the floriform metal fluoride nano material and is cheap in raw material, easy in raw material obtaining, short in synthesis route, short in time, simple in operation and low in production cost, and in addition, the prepared floriform metal fluoride nanomaterial is small in particle size and thus is large in specific surface area, rich in active site and good in electrochemical activity and catalysis activity.

The invention provides a method for preparation of fluorescent silica nanoparticles. The method includes: a), mixing indocyanine type fluorescent dye with an organic silicon source compound to obtain a precursor solution; b), allowing the precursor solution to react under constant temperature to obtain the fluorescent silica nanoparticles. The water-soluble fluorescent silica nanopartricles are prepared with the one-step method which is performed completely in water phase, so that the method is safe in operation, rapid and convenient, low in toxicity and safe and easy in obtaining raw materials; the water-soluble fluorescent silica nanoparticles are quite good in monodispersity, high in fluorescent property and quantum yield, good in stability, good in water solubility, capable of serving as fluorescence indicators widely applied to biological detection and analysis and hopeful to be used for optical related industrial production such as laser and organic light emitting diodes.

The invention provides a borane compound used for antibacterial treatment. The borane compound is a dodecaborane substituted amide or a dodecaborane-oxazole. The preparation method comprises: (1) taking a mono-aminated dodecaborane as a raw material and performing an acylation reaction with an acyl chloride compound under the effect of sodium hydride to obtain a dodecaborane substituted amide; and (2) performing oxidative coupling on the dodecaborane substituted amide obtained in the step (1) under the effect of (diacetoxyiodo)benzene to obtain a dodecaborane-oxazole. The invention also provides an application of the borane compound in preparing antibacterial agents. The borane compound has extremely high antibacterial activity on certain Gram negative bacteria, and has a huge prospect.

The invention belongs to the field of organic synthesis and provides a preparation method of bromhexine hydrochloride. The present invention uses 2-aminobenzoate compounds as raw materials to obtain bromhexine hydrochloride after bromination reaction, reduction reaction, condensation reaction and salt-forming reaction, the synthetic route is short, the cost is low, the intermediate is stable, and it is environmentally friendly Pollution, high purity, high yield, in line with pharmaceutical standards, suitable for industrial expansion of production.

The invention discloses a 3-substituted oxazole-fused caged dodecaborane compound, a preparation method and application thereof. The structure of the 3-substituted oxazole fused caged dodecaborane compound is as shown in formula (I), and the R 1 Be menthyl or camphoryl; The R 2 for H, C 6‑20 Aryl, C 1‑15 Alkyl, ‑C(O)O‑C 1‑5 Alkyl or ‑C(O)O‑C 6‑20 Aryl, the C 6‑20 Aryl is optionally replaced by 1, 2 or 3 H, F, Cl, Br, I, OH, NH 2 , NO 2 , CN, C 1‑5 Alkyl, C 1‑5 Alkoxy, -O-C(O)-C 1‑5 Alkyl, ‑C(O)‑NH‑C 1‑5 Alkyl, ‑NH‑C(O)‑C 1‑5 Alkyl, ‑C(O)O‑C 1‑5 Alkyl, C 6‑20 Aryl or 5-12 membered heteroaryl substituted; said A + For metal cations, quaternary ammonium cations or phosphorus cations. The preparation method utilizes menthyl and camphoryl as a directing group, selectively activates the 3-position B-H bond, and prepares the compound of formula (I); the stereoselectivity is high, and the yield is good, which increases the chance of discovering new antibacterial drug candidates . The compound of formula (I) provided by the invention has high-efficiency and broad-spectrum antibacterial effects.

The invention provides a cross-linked polyethylene and its preparation method and application, and relates to the technical field of modification and processing of polyethylene. The cross-linking modification and recycling processing of polyethylene are realized through the reversibility and cyclicity of Diels-Alder reaction between furan-modified polyethylene and organic cross-linking agent, hybrid cross-linking agent or inorganic cross-linking agent, respectively. The preparation method of the novel recyclable cross-linked polyethylene of the invention is simple, the raw material is cheap, the physical properties of the cross-linked polyethylene are greatly improved, and the resistance to environmental stress cracking, corrosion resistance, weather resistance, creep resistance and the like are significantly improved. The cross-linked waste can be de-crosslinked through twin-screw melt processing to achieve reverse Diels-Alder reaction to achieve recycling, reducing environmental pollution and resource waste, and endowing it with the performance of recycling while improving the performance of polyethylene.

The invention discloses a method for preparing 4-(6-aminopyridin-3-yl) piperazine-1-carboxylate tert-butyl ester. The method for preparing 4-(6-aminopyridin-3-yl) piperazine-1-carboxylate tert-butyl ester comprises the following steps: 2-aminopyridin, piperazine-1-formate tert-butyl ester and NSP-SA-NHS photo catalyst is added to the solvent, and the light reaction is carried out under the condition of the presence of an oxidizing agent to generate 4-(6-aminopyridin-3-yl) piperazine-1-carboxylate tert-butyl ester. According to the method, 4-(6-aminopyridin-3-yl) piperazine-1-carboxylate tert-butyl ester is synthesized by one step. On the one hand, the synthetic route of 4-(6-aminopyridin-3-yl) piperazine-1-carboxylate tert-butyl ester is effectively shortened, the generation of by-productsis effectively reduced and the yield of the target product is improved. On the other hand, only photo catalyst and oxidizing agent are used, so that the preparation method is safe and environment-friendly and low in cost.

The invention provides a high-entropy rare earth co-doped nanometer low heat transfer powder material and a preparation method thereof, comprising the following steps: (1) putting rare earth source, boron source and intermediate into a high pressure reaction kettle, and flushing hydrogen , heat up to 320-340 ℃ and fully stir for activation, extract and layer the obtained product, carry out suction filtration washing, drying, then wet grinding, spray granulation of the obtained slurry, and granulate the obtained slurry. The spherical powder is dry-milled to obtain a precursor; (2) the precursor is loaded into a rotary kiln for calcination, a hydrogen-nitrogen mixture is introduced into the rotary kiln, the temperature is raised to 900-1200°C, the temperature is kept for 30-450min, and the temperature is lowered. and (3) removing impurities from the initial product to obtain the high-entropy rare earth co-doped nanometer low heat transfer powder material. The high-entropy rare earth co-doped nanometer low heat transfer powder material of the present invention has small scattered and fluffy particle size, low required temperature and low energy consumption.