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Core-shell type molecularly imprinted polymer capable of recognizing erythrosine and preparation method

A molecular imprinting, polymer technology, applied in separation methods, alkali metal compounds, chemical instruments and methods, etc., to achieve fast and accurate specific identification, overcome mass transfer, overcome slow kinetics effects

Inactive Publication Date: 2017-10-20
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the advantages and characteristics of molecularly imprinted polymers, if it is used as an adsorbent in the detection of erythrosin, the recovery rate of erythrosine will be greatly improved, and there is no information about erythrosine molecularly imprinted polymers. Related articles of research significance

Method used

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  • Core-shell type molecularly imprinted polymer capable of recognizing erythrosine and preparation method
  • Core-shell type molecularly imprinted polymer capable of recognizing erythrosine and preparation method
  • Core-shell type molecularly imprinted polymer capable of recognizing erythrosine and preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027] Example 1: Silica surface amination modification

[0028] Accurately weigh 1g of solid sodium hydroxide, add 100mL of ultrapure water to dissolve, and prepare a sodium hydroxide aqueous solution with a concentration of 0.25 moL / L; accurately measure 6.18mL of hydrochloric acid, add 93.82mL of ultrapure water to dilute, and prepare a concentration of 2moL / L of hydrochloric acid aqueous solution.

[0029] (1) Activation of silica: Accurately weigh 10g of silica microspheres into a 250mL round bottom flask, add 100mL of NaOH (0.25 mol / L), place on a magnetic stirrer, stir and corrode at room temperature for 30 min, then Eluted with ultrapure water; the alkali-treated silica was then refluxed with 100 mL, 2 moL / L HCl at 90°C for 8 h, and then eluted with ultrapure water until neutral and dried.

[0030] (2) Silica surface amination: Weigh 10 g of activated silica into a 250 mL round bottom flask, add 100 mL of toluene, and then add 5 mL of 3-aminopropyltriethoxysilane (A...

example 2

[0031] Example 2: Preparation of erythrosine molecularly imprinted polymers and non-molecularly imprinted polymers

[0032] Accurately weigh 0.2375mmoL of erythrosine and dissolve it in 50 mL of methanol:water=4:1 (v / v), and add the functional body 4-VP (0.95mmoL) into the solution, stir and incubate at room temperature for 2 h, then Surface-modified silica (1 g), cross-linking agent EGDMA (4.75 mmoL), and initiator AIBN (0.014 g) were added in sequence, mixed by ultrasonic waves, then put into a round-bottomed flask, stirred magnetically at room temperature for 10 min, and then added Install a three-way glass tube, and pass through nitrogen (60min) to remove oxygen.

[0033] Place the airtight container containing the above reaction solution on a magnetic stirrer, adjust the appropriate speed and continue to stir, heat in an oil bath at 70°C, take it out after 24 hours of reaction, and the reaction solution polymerizes to prepare the erythrosine molecularly imprinted polymer ...

example 3

[0035] Example 3: Adsorption kinetics experiment

[0036] Accurately weigh 7.2 mg of erythrosine solid sample, dissolve it in 12 mL of ultrapure water, and mix it by ultrasonic to prepare an erythrosine aqueous solution with a concentration of 600 μg / mL. Take 10 4mL centrifuge tubes and mark the serial number, then weigh 10 mg of the prepared MIP microspheres and NIP microspheres and place them in them, 5 tubes for each of the two types of microspheres. Add 1mL of 600 μg / mL erythrosin aqueous solution to each centrifuge tube, ultrasonically mix, and then stand at room temperature for adsorption. Take samples when the adsorption time is 5, 15, 30, 45, and 60 min, centrifuge to get the supernatant, measure its absorbance at 533nm with an ultraviolet-visible spectrophotometer (Uv-vis), and calculate it by the formula (1) The adsorption capacity (Q) was observed to observe the change rule of the adsorption capacity with the adsorption time.

[0037]

[0038] Among them, Q is ...

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Abstract

The invention relates to a core-shell type molecularly imprinted polymer capable of recognizing erythrosine and a preparation method, which belong to the technical field of molecularly imprinted function materials, and concretely relates to a polymer material with a specific recognition function on the artificially synthesized pigment erythrosine prepared based on a molecularly imprinted technology. Amino-modified silicon dioxide is adopted as a core, an erythrosine pigment molecule is adopted as a template, and a layer of imprinted layer is used for coating the surface thereof. The core-shell type molecularly imprinted polymer capable of recognizing the erythrosine and the preparation method provided by the invention have the advantages that imprinted loci are located on the surface of the polymer, the template is easy to elute from the polymer, the defects of dynamics slow and mass transfer during an adsorption / desorption process are overcome, the specific recognition can be quickly and accurately carried out on the erythrosine, the operation step can be simplified, the usage amount of a solvent is reduced, and the recovery rate is improved.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted functional materials, and is a polymer material with a specific recognition function for artificially synthesized pigment erythrosin prepared based on molecular imprinting technology, which can be specifically identified and separated by erythrosin. Background technique [0002] As a synthetic pigment, erythrosine is often used in food to improve its sensory properties due to its strong coloring power, good stability and low cost. For most synthetic food colorants, it is not a nutrient and cannot be absorbed by the human body, and its preparation often uses benzene and toluene as raw materials, undergoes a series of sulfonation and nitration reactions, and may be mixed during the synthesis process. Heavy metals such as arsenic and lead, if abused, will pose a huge threat to the health of consumers. my country has clear standards and limits for the use of food coloring agents. At pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/20C08F226/06C08J9/28C08L33/08C08K9/02C08K9/06C08K7/18B01J20/26B01J20/28B01J20/30B01D15/38
CPCB01D15/3852B01J20/268B01J20/28021C08F220/20C08J9/28C08J2333/08C08K7/18C08K9/02C08K9/06C08F226/06C08L33/08
Inventor 谢卫红刘静静张瑞严恒
Owner HUBEI UNIV OF TECH
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