Blood-fat-lowering simvastatin sustained-release tablet and preparation method thereof
A technology for simvastatin and sustained-release tablets, applied in the field of simvastatin sustained-release tablets and their preparation, can solve the problems of large fluctuation of blood drug concentration, short drug effect time, short half-life and the like, achieve delayed release, control of blood lipids, low cost effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0035] A blood lipid-lowering simvastatin sustained-release tablet, consisting of a core containing simvastatin and a coating layer wrapped outside the core, the core comprising the following materials in parts by weight: 12 parts of simvastatin, tangerine 50 parts of carbide of leather;
[0036] The present invention also provides a preparation method of the simvastatin sustained-release tablet, comprising the following steps:
[0037] (1) Soak the orange peel in salt water for 40 minutes, dry it, and carbonize it in an inert gas to obtain a porous carbon material. The concentration of the salt water is 10 g / mL, and the carbonization temperature is 600 ° C. The time is 5 hours;
[0038] (2) Mix simvastatin, porous carbon material, polyethylene glycol, castor oil, magnesium stearate, microcrystalline cellulose, gum arabic, ascorbic acid, and sodium dehydroacetate evenly, granulate, dry, and tablet , made into a tablet core containing simvastatin;
[0039] (3) Add 5 parts of...
Embodiment 2
[0042] A blood lipid-lowering simvastatin sustained-release tablet, consisting of a tablet core containing simvastatin and a coating layer wrapped outside the tablet core, the tablet core includes the following materials in parts by weight: 10 parts of simvastatin, aloe 50 parts of carbides;
[0043] The simvastatin sustained-release tablet also contains the following substances: microcrystalline cellulose, preservatives, antioxidants;
[0044] The present invention also provides a preparation method of the simvastatin sustained-release tablet, comprising the following steps:
[0045] (1) Soak Aloe Vera in salt water for 30 minutes, after drying, carbonize in an inert gas to obtain a porous carbon material, the concentration of the salt water is 5g / mL, the carbonization temperature is 300°C, and the carbonization time for 4 hours;
[0046] (2) After mixing simvastatin, porous carbon material, polyethylene glycol, glycerin, magnesium stearate, talcum powder, starch, karaya gu...
Embodiment 3
[0050] A blood lipid-lowering simvastatin sustained-release tablet, which consists of a tablet core containing simvastatin and a coating layer wrapped outside the tablet core, and the tablet core includes the following materials in parts by weight: 8 parts of simvastatin, laver 80 parts of carbides;
[0051] The present invention also provides a preparation method of the simvastatin sustained-release tablet, comprising the following steps:
[0052] (1) Soak laver in salt water for 10 minutes, after drying, carbonize in an inert gas to obtain a porous carbon material, the concentration of the salt water is 15g / mL, the carbonization temperature is 700°C, and the carbonization time for 8 hours;
[0053] (2) Mix simvastatin, porous carbon material, polyvinylpyrrolidone, glycerin, micropowdered silica gel, sucrose, arabinogalactan, and butyl hydroxyanisole hydroperoxide evenly, granulate, dry, and tablet. into a tablet core containing simvastatin;
[0054] (3) Add 5 parts of hyd...
PUM
Property | Measurement | Unit |
---|---|---|
Concentration | aaaaa | aaaaa |
Concentration | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com