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Preparation method for health product resveratrol

A technology for resveratrol and health care products, applied in the field of health care products, can solve the problems of being inconsistent with environmental protection, prone to side reactions, difficult to control the reaction, etc., and achieves good cycle repeatability, simple post-processing and purification, and mild reaction conditions. Effect

Inactive Publication Date: 2017-11-10
安徽世华化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acetylation protection has the advantage of easy deprotection, but it needs to use a large amount of acetic anhydride when protecting the group, which is uneconomical and causes a lot of pollution; due to the presence of alkenyl in the substrate, debenzylation protection and demethylation protection The Lewis acid catalysis method is always used, the reaction is not easy to control, side reactions are prone to occur, and a large amount of waste water is generated during post-treatment, which does not conform to the concept of green environmental protection

Method used

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  • Preparation method for health product resveratrol
  • Preparation method for health product resveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Get 4.94g triphenylphosphine gold chloride and 3.87g and two (trifluoromethanesulfonate group) silver ammonium in the reaction flask of 50ml band magnetic stirrer, after replacing reaction flask with argon gas 5 times, add 8.4g di Chloromethane, stirred at room temperature for 1 h. After completion of the reaction, suction filter the mother liquor into a new 100ml reaction flask, wash the filter cake with 8.4g of dichloromethane, and dry the by-product silver chloride; combine the filtrates to obtain a dichloromethane solution of MHZ001. Add 20g of γ-alumina to the dichloromethane solution of the obtained MHZ001, adjust the data of the rotary evaporator to 40°C, 0.01MPa, and evaporate the impregnation solution to dryness to obtain the γ-Al-MHZ001 catalyst, which can be used by recovering the dichloromethane.

[0025] Take 34.8g of the prepared 3,5,4'-triallyloxystilbene and place it in a 250ml reaction flask with a magnetic stirrer, add 84g of dichloromethane and stir t...

Embodiment 2

[0027] Get 4.94g triphenylphosphine gold chloride and 3.87g and two (trifluoromethanesulfonic acid group) silver ammonium in the reaction flask of 100ml band magnetic stirrer, after replacing reaction flask with argon gas 5 times, add 42g dichloro methane, stirred at room temperature for 1 h. After completion of the reaction, suction filter the mother liquor into a new 100ml reaction flask, wash the filter cake with 8.4g of dichloromethane, and dry the by-product silver chloride; combine the filtrates to obtain a dichloromethane solution of MHZ001. Add 20g of γ-alumina to the dichloromethane solution of the obtained MHZ001, adjust the data of the rotary evaporator to 40°C, 0.01MPa, and evaporate the impregnation solution to dryness to obtain the γ-Al-MHZ001 catalyst, which can be used by recovering the dichloromethane.

[0028] Take 34.8g of the prepared 3,5,4'-triallyloxystilbene and place it in a 250ml reaction flask with a magnetic stirrer, add 168g of dichloromethane and s...

Embodiment 3

[0030] Get 4.34g tri-tert-butylphosphine gold chloride and 3.87g and two (trifluoromethanesulfonic acid group) silver ammonium in the reaction bottle of 50ml band magnetic stirrer, after replacing reaction bottle with argon gas 5 times, add 8.4g Dichloromethane was stirred at room temperature for 1 h. After the reaction is complete, suction filter the mother liquor into a new 100ml reaction flask, wash the filter cake with 8.4g of dichloromethane, and dry the by-product silver chloride; combine the filtrates to obtain a dichloromethane solution of MHZ002. Add 20g of γ-alumina to the dichloromethane solution of the obtained MHZ001, adjust the data of the rotary evaporator to 40°C, 0.01MPa, and evaporate the impregnation solution to dryness to obtain the γ-Al-MHZ002 catalyst, which can be used by recovering the dichloromethane.

[0031] Take 34.8g of the prepared 3,5,4'-triallyloxystilbene and place it in a 250ml reaction flask with a magnetic stirrer, add 84g of dichloromethane...

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Abstract

The present invention provides a preparation method of health care product resveratrol. 1. The deprotection method used in the present invention is green, environmentally friendly and pollution-free. economic value. 2. The catalyst used in the present invention has good cycle repeatability, which can reach more than 50 times. 3. The method involved in the present invention requires simple operation, mild reaction conditions, strong specificity, simple post-treatment and purification of the product, and is suitable for industrial production. 4. The resveratrol prepared by the method involved in the present invention has no impurities and extremely high purity.

Description

technical field [0001] The invention relates to the technical field of health products, in particular to a preparation method of the health product resveratrol. Background technique [0002] Resveratrol is an emerging raw material for health products, and its health functions include anti-oxidation, anti-aging, anti-inflammation and anti-cancer. At present, the main source of commercially available resveratrol is Polygonum cuspidatum plant extract, which has high production cost, low utilization rate, large solvent loss, large solid waste, and insufficient production capacity to meet market demand. The chemical synthesis method has the characteristics of cost-effective, high-yield and high-purity. The chemically synthesized resveratrol can perfectly make up for the market demand. It is imminent to develop and optimize the method of synthesizing resveratrol. At present, the most mainstream method for synthesizing resveratrol is the Wittig-Honor method, and its hydroxyl prote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/055C07C39/21
CPCC07C37/055C07C41/16C07C41/22C07C41/30C07F9/4056C07F9/4075
Inventor 孔令航马家松王斌马祥梅石建军胡劲松孙徽
Owner 安徽世华化工有限公司
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