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Preparation method for health product pterostilbene

A technology for red sandalwood and health care products, applied in the field of health care products, can solve the problems of not conforming to green environmental protection, difficult to control reaction, prone to side reactions, etc. Effect

Inactive Publication Date: 2017-11-10
安徽世华化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acetylation protection has the advantage of easy deprotection, but it needs to use a large amount of acetic anhydride when protecting the group, which is uneconomical and causes a lot of pollution; due to the presence of alkenyl in the substrate, debenzylation protection and demethylation protection The Lewis acid catalysis method is always used, the reaction is not easy to control, side reactions are prone to occur, and a large amount of waste water is generated during post-treatment, which does not conform to the concept of green environmental protection

Method used

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  • Preparation method for health product pterostilbene
  • Preparation method for health product pterostilbene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Get 4.94g triphenylphosphine gold chloride and 3.87g and two (trifluoromethanesulfonate group) silver ammonium in the reaction flask of 50ml band magnetic stirrer, after replacing reaction flask with argon gas 5 times, add 8.4g di Chloromethane, stirred at room temperature for 1 h. After completion of the reaction, suction filter the mother liquor into a new 100ml reaction flask, wash the filter cake with 8.4g of dichloromethane, and dry the by-product silver chloride; combine the filtrates to obtain a dichloromethane solution of MHZ001. Add 20g of γ-alumina to the dichloromethane solution of the obtained MHZ001, adjust the data of the rotary evaporator to 40°C, 0.01MPa, and evaporate the impregnation solution to dryness to obtain the γ-Al-MHZ001 catalyst, which can be used by recovering the dichloromethane.

[0025] Take the prepared 3,5-dimethoxy-4'-allyloxystilbene 29.6g and place it in a 250ml reaction flask with a magnetic stirrer, add 84g of dichloromethane and st...

Embodiment 2

[0027] Get 4.94g triphenylphosphine gold chloride and 3.87g and two (trifluoromethanesulfonic acid group) silver ammonium in the reaction bottle of 50ml band magnetic stirrer, after replacing reaction bottle with argon gas 5 times, add 42g dichloro methane, stirred at room temperature for 1 h. After completion of the reaction, suction filter the mother liquor into a new 100ml reaction flask, wash the filter cake with 8.4g of dichloromethane, and dry the by-product silver chloride; combine the filtrates to obtain a dichloromethane solution of MHZ001. Add 20g of γ-alumina to the dichloromethane solution of the obtained MHZ001, adjust the data of the rotary evaporator to 40°C, 0.01MPa, and evaporate the impregnation solution to dryness to obtain the γ-Al-MHZ001 catalyst, which can be used by recovering the dichloromethane.

[0028] Take the prepared 3,5-dimethoxy-4'-allyloxystilbene 29.6g and place it in a 250ml reaction flask with a magnetic stirrer, add 168g of dichloromethane ...

Embodiment 3

[0030] Get 4.34g tri-tert-butylphosphine gold chloride and 3.87g and two (trifluoromethanesulfonic acid group) silver ammonium in the reaction bottle of 50ml band magnetic stirrer, after replacing reaction bottle with argon gas 5 times, add 8.4g Dichloromethane was stirred at room temperature for 1 h. After the reaction is complete, suction filter the mother liquor into a new 100ml reaction flask, wash the filter cake with 8.4g of dichloromethane, and dry the by-product silver chloride; combine the filtrates to obtain a dichloromethane solution of MHZ002. Add 20g of γ-alumina to the dichloromethane solution of the obtained MHZ001, adjust the data of the rotary evaporator to 40°C, 0.01MPa, and evaporate the impregnation solution to dryness to obtain the γ-Al-MHZ002 catalyst, which can be used by recovering the dichloromethane.

[0031] Take the prepared 3,5-dimethoxy-4'-allyloxystilbene 29.6g and place it in a 250ml reaction flask with a magnetic stirrer, add 84g of dichloromet...

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Abstract

The invention provides a preparation method for a health product pterostilbene. According to the invention, 1, a deprotection method used in the invention is green, environment-friendly and pollution-free, the preparation method is almost free of production of waste gas, waste water and industrial residues, and the product 1,4-pentadiene has economic value; 2, a catalyst used in the invention has good cycle repeatability and can be cyclically used 50 times or more; 3, the preparation method is simple in operation requirements, mild in reaction conditions, good in specificity, simple in post-treatment and purification of the product, and suitable for industrial production; and 4, the pterostilbene prepared by using the method is free of impurities like 3-methoxy-4',5-dihydroxystilbene and resveratrol and has high purity.

Description

technical field [0001] The invention relates to the technical field of health care products, in particular to a preparation method of the health care product pterostilbene. Background technique [0002] Pterocarpus stilbene is an emerging raw material for health products, and its health functions include anti-oxidation, anti-aging, anti-inflammation and anti-cancer. The main source of currently commercially available red sandalwood stilbene is blueberry plant extract and red sandalwood plant extract, which have high production costs, low utilization rate, large solvent loss, large solid waste, and insufficient production capacity to meet market demand. The chemical synthesis method has the characteristics of economical efficiency, high yield and high purity. The chemically synthesized pterostilbene can perfectly meet the market demand, and it is imminent to develop and optimize the method of synthesizing pterostilbene. At present, the most mainstream method for synthesizing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/26C07C43/23
CPCC07C41/26C07C41/16C07C41/22C07C41/30C07F9/4056C07F9/4075
Inventor 孔令航马家松王斌马祥梅石建军胡劲松孙徽
Owner 安徽世华化工有限公司
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