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Preparation method and application of a tumor-targeted photothermal therapy nanocarrier

A photothermal therapy and tumor-targeting technology, which is applied in the field of preparation of nanocarriers for tumor-targeted photothermal therapy, can solve the problems of normal cell damage, patient trauma and complications, and achieve good photothermal therapy effect and good photothermal therapy effect. The effect of simple and convenient conversion characteristics and preparation methods

Active Publication Date: 2019-12-06
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods all have great risks, which are likely to bring great trauma and complications to patients, and at the same time, they are likely to cause great damage to normal cells while killing cancer cells.

Method used

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  • Preparation method and application of a tumor-targeted photothermal therapy nanocarrier
  • Preparation method and application of a tumor-targeted photothermal therapy nanocarrier
  • Preparation method and application of a tumor-targeted photothermal therapy nanocarrier

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A method for preparing a tumor-targeted photothermal therapy nanocarrier, comprising the following steps:

[0041] S1. Preparation of GO-MoS 2 Composite: get ammonium molybdate 0.265g, sodium sulfide 1.152g, dissolve in 25ml water respectively, obtain ammonium molybdate and sodium sulfide solution; get 2.5ml (mass concentration is 1%) graphene oxide sol, dilute to 100ml, GO solution was obtained; the ammonium molybdate solution was added to the GO solution, magnetically stirred for 30 minutes, then the sodium sulfide solution was slowly added, and 10ml of 5mol / L hydrochloric acid was added dropwise, and the reaction was carried out for 1 hour;

[0042] S2. Then add 2 g of L-cysteine ​​to the reaction solution, adjust the pH to 4.5, put it into a hydrothermal kettle and react at 200° C. for 24 hours;

[0043] S3, after the reaction solution is cooled, centrifuge and wash at 3500 rpm for 5 min (repeat 6 times), discard the supernatant; obtain sample A;

[0044] S4. Modi...

Embodiment 2

[0049] Repeat Example 1, the only difference is: in the preparation of GO-MoS 2 In the compound process, adjust the addition of sodium sulfide to 0.58g or 2.30g, and the rest of the steps are the same as in Example 1, and MoS can be obtained 2 Samples with different loading ratios.

Embodiment 3

[0051] Repeat Example 1, the only difference is: in the preparation of GO-MoS 2 In the composite process, the graphene oxide powder obtained by the modified Hammers method is used instead of the graphene oxide sol, and the rest of the steps are the same as in Example 1, and GO-MoS can also be prepared 2 The complex can be used to compare the effect of different raw materials on the cytotoxicity of the vector.

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Abstract

The invention discloses a preparation method of a tumor targeted photothermal therapy nanocarrier. The method comprises steps as follows: with GO as a carrier, loading MoS2 on GO with a hydrothermal method, and performing PEG modification to obtain the GO-MoS2 composite carrier. A composite of GO and MoS2 is taken as a phototherapeutic drug carrier for the first time, the preparation method is simple and convenient, and conditions are mild; the prepared GO-MoS2 drug-carrying composite has good photothermal conversion characteristic and higher drug carrying ratio which is higher than or equal to 80%. The drug release rate of the GO-MoS2 drug-carrying composite is 78% under laser power of 1.8 W / cm<2> in the presence of NIR laser. Compared with a conventional photothermal therapy nano-drug carrier, the GO-MoS2 drug-carrying composite has higher photo-thermal conversion rate due to synergistic effect of the two materials.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a preparation method and application of a tumor-targeted photothermal therapy nanocarrier. Background technique [0002] As a major disease that threatens human life and health, cancer has long been characterized by low cure rate, high recurrence and high mortality. From the statistical point of view, from 2010 to 2015, the number of new cancer cases in my country has shown a clear upward trend, with about 300,000 new cases every year, and the number of deaths has also increased year by year. In 2015, it was 2.814 million cases. . The global cancer incidence has also been on the rise since 2008. In 2012, the number of cases was 14 million, and the number of cases is expected to reach 24 million in 2035. And in recent years, due to people's high life pressure, irregular work and rest diet, and more opportunities to be exposed to carcinogenic factors, new cancer ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/60A61K47/04A61K47/02A61P35/00
CPCA61K31/704A61K41/0052A61K47/02A61K2300/00
Inventor 乐园林谡轩陈鹏沈煜栋
Owner BEIJING UNIV OF CHEM TECH
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