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Curcumin porous silicon and preparation method thereof

A technology of porous silicon and curcumin, applied in the field of curcumin, can solve the problems of undiscovered curcumin, achieve the effects of improving bioavailability, water solubility and stability, and easy modification

Inactive Publication Date: 2017-11-24
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, porous silicon has been widely used as a carrier of insoluble substances due to its unique advantages such as huge specific surface area and volume, good chemical stability, controllable size and nanopores, and easy modification. No research on loading curcumin with porous silicon as a carrier was found

Method used

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  • Curcumin porous silicon and preparation method thereof
  • Curcumin porous silicon and preparation method thereof
  • Curcumin porous silicon and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A curcumin porous silicon comprises a carrier, a main drug and an inducer; the carrier is porous silicon, the main drug is curcumin, and the inducer is sodium nitrite.

[0027] A preparation method of curcumin porous silicon, comprising the following steps:

[0028] (1) Pretreatment of silicon wafers

[0029] Select a P-type boron-doped single crystal silicon wafer with a resistance of 0.0008-0.0012ohm, and cut it into spare silicon wafers of 3×3cm. The silicon wafers are ultrasonically treated with acetone, methanol, and deionized water under ultrasonic waves, and then placed in NH with a volume ratio of 1:1:5 4 OH, H 2 o 2 、H 2 O mixed solution and HCl, H with a volume ratio of 1:1:5 2 o 2 , H 2 Heating in a water bath in the O mixture, the heating temperature of the water bath is 75°C, and the heating time of the water bath is 15 minutes; after washing, soak in ethanol for later use;

[0030] (2) Preparation of porous silicon

[0031] The above-mentioned pre...

Embodiment 2

[0038] A curcumin porous silicon comprises a carrier, a main drug and an inducer; the carrier is porous silicon, the main drug is curcumin, and the inducer is sodium nitrite.

[0039] A preparation method of curcumin porous silicon, comprising the following steps:

[0040] (1) Pretreatment of silicon wafers

[0041] Select a single crystal silicon wafer doped with P-type boron, with a resistance of 0.0008-0.0012ohm, and cut it into spare silicon wafers of 3×3cm. The silicon wafers are ultrasonically treated with acetone, methanol, and deionized water under ultrasonic waves, and then placed successively. In NH with a volume ratio of 1:1:5 4 OH, H 2 o 2 、H 2 O mixed solution and HCl, H with a volume ratio of 1:1:5 2 o 2 、H 2 Heating in a water bath in the O mixture, the heating temperature of the water bath is 75°C, and the heating time of the water bath is 15 minutes; after washing, soak in ethanol for later use;

[0042] (2) Preparation of porous silicon

[0043] The ab...

Embodiment 3

[0047] A curcumin porous silicon comprises a carrier, a main drug and an inducer; the carrier is porous silicon, the main drug is curcumin, and the inducer is sodium nitrite.

[0048] A preparation method of curcumin porous silicon, comprising the following steps:

[0049] (1) Pretreatment of silicon wafers

[0050] Select a single crystal silicon wafer doped with P-type boron, with a resistance of 0.0008-0.0012ohm, and cut it into spare silicon wafers of 3×3cm. The silicon wafers are ultrasonically treated with acetone, methanol, and deionized water under ultrasonic waves, and then placed successively. In NH with a volume ratio of 1:1:5 4 OH, H 2 o 2 、H 2 O mixed solution and HCl, H with a volume ratio of 1:1:5 2 o 2 、H 2 Heating in a water bath in the O mixture, the heating temperature of the water bath is 75°C, and the heating time of the water bath is 15 minutes; after washing, soak in ethanol for later use;

[0051] (2) Preparation of porous silicon

[0052] The ...

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Abstract

The invention relates to curcumin porous silicon and a preparation method thereof. The curcumin porous silicon comprises a carrier, a main medicine and an inducer, wherein the carrier is a porous silicon body, the main medicine is curcumin, and the inducer is sodium nitrite. According to the preparation method, a silicon wafer is subjected to ultrasonic treatment under ultrasonic waves through acetone, methanol and deionized water and water bath heating, and after washing, a silicon wafer for standby application is obtained; the treated silicon wafer is prepared into a porous silicon thin film through an electrochemical etching method, and the porous silicon thin film is stripped; after stripping, ultrasonic treatment and vacuum drying are conducted to prepare porous silicon particles; the porous silicon particles are added into a curcumin and sodium nitrite solution to obtain a suspension solution; and the suspension solution is subjected to still standing in a water bath and loaded for 3-21 h, the water bath temperature is 20-65 DEG C, and the curcumin porous silicon is prepared and obtained. The porous silicon has a certain slow-release effect, and the curcumin porous silicon can effectively improve the water solubility and stability of the curcumin and meanwhile improve the bioavailability of the curcumin.

Description

technical field [0001] The invention belongs to the field of curcumin, and in particular relates to a curcumin porous silicon and a preparation method thereof. Background technique [0002] Curcumin is a natural phenolic pigment extracted from turmeric, a ginger plant. Studies have shown that curcumin has good biological activities in anti-inflammation, antibacterial, anti-oxidation, and inhibition of tumor cell proliferation. It is a food functional factor with wide application value. However, curcumin has poor water solubility, easy oxidation, unstable chemical structure, high metabolic rate in biological systems, rapid elimination in the system, and short half-life, which make its bioavailability low, and curcumin has a spicy taste and is difficult to drink. . These problems have become the main obstacles for curcumin from the laboratory to the practical application. One of the biggest challenges in the development of curcumin for functional food development and clinic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K31/12A61P29/00A61P31/04A61P39/06A61P31/10A61P35/00A23L33/105A23L33/16
CPCA61K47/02A23L33/105A23L33/16A61K31/12A23V2002/00A23V2250/2112A23V2250/1628A23V2200/30A23V2200/308
Inventor 郑铁松李建林林清霞李玮张月金岩昊李奕辰李亚维张莉
Owner NANJING NORMAL UNIVERSITY
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