Blaps rynchopetera fairmaire extract E as well as preparation method and pharmaceutical application thereof

A technology of rostral pipa and pipa, applied in the field of pyridine compound rostral pipa and its preparation, to achieve potential social and economic benefits, convenient raw material sources, and easy-to-obtain raw material sources

Inactive Publication Date: 2017-11-24
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Except that the inventor of this patent has conducted a preliminary study on the anti-tumor and antibacteri...

Method used

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  • Blaps rynchopetera fairmaire extract E as well as preparation method and pharmaceutical application thereof
  • Blaps rynchopetera fairmaire extract E as well as preparation method and pharmaceutical application thereof
  • Blaps rynchopetera fairmaire extract E as well as preparation method and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 :Preparation and structure identification of beaktail Lutein A

[0029] 1.1 Experimental equipment and materials

[0030] NMR spectrum was measured by Bruker AV-400 nuclear magnetic resonance spectrometer (δ is ppm, TMS is internal standard, J is Hz); MS spectrum is measured by Agilent G3250AA LC / MSD TOF electrospray time-of-flight mass spectrometer; Rotary evaporator uses Heidolph, Germany; the circulating condensate pump adopts Japan's EYELA; the analytical balance adopts the pioneer manufactured by Ohaus Instrument (Shanghai) Co., Ltd. Sephadex LH-20 for column chromatography was purchased from Amphamacia Biotechnology (China) Co., Ltd.; ODS reversed-phase material was purchased from Merck; column-layer silica gel and thin-layer chromatography silica gel plates were Produced by Qingdao Ocean Chemical Plant. The elution solvents for chromatography are industrially pure solvents or chemically pure solvents that have been re-evaporated; the solvent used in the d...

Embodiment 2

[0043] Example 2 :Detection of the ability of compounds of formula (I) to scavenge 1,1-diphenyl-dipicrylhydrazine (DPPH) free radicals

[0044] 2.1 Experimental principle and experimental purpose

[0045] DPPH is a relatively stable lipid free radical with a free electron on its N, and its ethanol solution is purple. Scanning at the full wavelength shows that it has a maximum absorption peak at 517nm. After adding antioxidants, DPPH captures an electron to pair with free electrons, the purple fades and becomes a colorless substance, and the absorption peak at 517nm disappears. The degree of fading has a quantitative relationship with the number of electrons it accepts. That is, the absorption value of DPPH decreases when it is redox, and the lower the absorbance, the stronger its antioxidant effect. According to this principle, the ability of the sample to provide hydrogen atoms, scavenge free radicals, and resist oxidation can be measured.

[0046] 2.2 Methods and results

[00...

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Abstract

The invention relates to a blaps rynchopetera fairmaire extract E as well as a preparation method and pharmaceutical application thereof and in particular relates to the blaps rynchopetera fairmaire extract E which is separated from pharmaceutical insects blaps rynchopetera fairmaire, and application of a compound to preparation of an antioxidant. A structural formula of the blaps rynchopetera fairmaire extract E is bi-2-hydroxymethyl-5-pyridyl ether and the blaps rynchopetera fairmaire extract E has the bioactivity of remarkably eliminating DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radicals (an IC50 value is 44.12+/-8.80 micrograms/millimeter). The blaps rynchopetera fairmaire extract E provided by the invention has the novelty and great potential of being developed into the innovative antioxidant and can be expectedly developed into the antioxidant for preventing and controlling physiological changes and diseases related to the free radical.

Description

Technical field [0001] The invention relates to the field of medical technology. Specifically, the present invention relates to a pyridine compound Beaconium A which is isolated from a medicinal insect Beaconium and a preparation method and medical use thereof. The compound has the activity of scavenging DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radicals, and can be expected to develop into an antioxidant that prevents physiological changes or diseases related to free radicals. Background technique [0002] Free radicals are active molecules produced by the human body during life activities. Under normal circumstances, the body's antioxidant defense system can scavenge free radicals to maintain a balance between production and elimination. When the production and removal of free radicals is out of balance, it will cause body damage, induce various diseases, and accelerate aging. Free radicals can cause a variety of human diseases: oxidative damage to brain tissue by free radic...

Claims

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Application Information

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IPC IPC(8): C07D213/66A61K31/444A61P39/06
CPCC07D213/66
Inventor 巫秀美尹田鹏肖怀罗建蓉李万平何苗罗情刘熙刘光明
Owner DALI UNIV
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