A kind of ceftaroning nano-suspension freeze-dried powder and preparation method thereof

A nano-suspension, cefuroxime technology, applied in the field of cefuroxime preparations, can solve the problems of cefuroning insoluble in water, high organic solvent content, unfavorable popularization and application, etc., to improve chemical stability, stable Good performance, easy to popularize and apply
CN107412170BActive Publication Date: 2020-08-21SOUTH CHINA AGRI UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2020-08-21

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Abstract

The invention discloses cefalonium nanosuspension freeze-dried powder and a preparation method of the cefalonium nanosuspension freeze-dried powder. The cefalonium nanosuspension freeze-dried powder is prepared from the following components in parts by weight: 1-5 parts of cefalonium raw drug, 0.1-0.5 part of a surfactant, 0.1-0.5 part of a suspending aid, and 1-10 parts of a freeze-drying protective agent. The cefalonium nanosuspension freeze-dried powder prepared by adopting the preparation method disclosed by the invention has good stability, and is uniform in particle size distribution and good in redispersibility, and the solubility and bioavailability of cefalonium can be improved; an organic solvent is not used in a formula, the use of auxiliary materials is little, the toxic and side effects are small, a preparation process is simple, and the popularization and application are convenient. The cefalonium nanosuspension freeze-dried powder disclosed by the invention has good inhibitory activity for clinical isolates of staphylococcus aureus, streptococcus and escherichia coli.
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Description

technical field

[0001] The invention relates to a preparation of cefuroxime, in particular to a cefuroxime nano-suspension freeze-dried powder and a preparation method thereof. Background technique

[0002] The molecular formula of ceftaroline is C 20 h 18 N 4 o 5 S 2 , with a molecular weight of 458.5. Cefalonine belongs to the first generation of semi-synthetic cephalosporin broad-spectrum antibiotics. It is a specific drug for the prevention and treatment of mastitis in dry milk cows. It has the advantages of broad antibacterial spectrum, strong bactericidal power, less allergic reactions, and low toxicity. Its mechanism of action is to lose its activity by binding to one or more penicillin-binding proteins located on the cell wall of sensitive bacteria, thereby hindering the synthesis of the cell wall of the bacteria, changing the permeability of the cell wall, increasing the osmotic pressure of the cells in the bacteria, and breaking the cell membrane. Body lysis ...

Claims

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