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Multi-vitamin element calcium preparation and preparing method thereof

A multi-dimensional element and calcium preparation technology, which is applied in pill delivery, pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, etc., to achieve good absorption effect, resist bone loss, and scientific steps

Inactive Publication Date: 2017-12-08
SHANGHAI NUOCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The human body excretes calcium from sweat and urine every day. The consumed calcium must also be supplemented from the daily intake of nutrients to achieve the balance of calcium in the body. However, since calcium is a nutrient that is not easily absorbed, Therefore, it is an essential nutrient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Process steps:

[0043] (1) Preparation of raw and auxiliary materials: Prepare calcium carbonate, vitamin D3, magnesium oxide, binder, and disintegrant according to the proportioning ratio. The formula ratio is as follows in parts by weight: calcium carbonate: 65 parts, vitamin D30.06 parts, magnesium oxide 17 parts, copper sulfate 0.2 parts, zinc sulfate 1.6 parts, binder 10 parts, disintegrant 2.14 parts, lubricant 1 part, 3 parts of coating powder; the binder is pregelatinized starch, the disintegrant is sodium carboxymethyl starch, and the lubricant is silicon dioxide.

[0044] (2) Preparation and pre-mixing of raw and auxiliary materials: take each component drug according to the weight of the formula ratio, first mix vitamin D3 and binder in equal amounts, and then add calcium carbonate, magnesium oxide, the remaining binder and disintegrant The solution is mixed.

[0045] (3) Granulation: put the mixed materials into a wet granulator, add purified water for mi...

Embodiment 2

[0053] Process steps:

[0054] (1) Preparation of raw and auxiliary materials: Prepare calcium carbonate, vitamin D3, magnesium oxide, binder, and disintegrant according to the proportioning ratio. Wherein the formula ratio is as follows by weight: calcium carbonate: 70 parts, vitamin D3 0.06 parts, magnesium oxide 16 parts, copper sulfate 0.2 parts, zinc sulfate 1.4 parts, binding agent 8 parts, disintegrant 1.34 parts, lubricant 1 part, 2 parts of coating powder; the binder is povidone K30, the disintegrant is sodium carboxymethyl starch, and the lubricant is magnesium stearate.

[0055] (2) Preparation and pre-mixing of raw and auxiliary materials: take each component drug according to the weight of the formula ratio, first mix vitamin D3 and binder in equal amounts, and then add calcium carbonate, magnesium oxide, the remaining binder and disintegrant The solution is mixed.

[0056] (3) Granulation: Put the mixed materials into a wet granulator, add purified water for mi...

Embodiment 3

[0064] Process steps:

[0065] (1) Preparation of raw and auxiliary materials: Prepare calcium carbonate, vitamin D3, magnesium oxide, binder, and disintegrant according to the proportioning ratio. Wherein the formula ratio is as follows by weight: calcium carbonate: 73.5 parts, vitamin D3 0.06 parts, magnesium oxide 16 parts, copper sulfate 0.2 parts, zinc sulfate 1.4 parts, binding agent 5 parts, disintegrant 1.34 parts, lubricant 0.5 part, 2 parts of coating powder; the binder is microcrystalline cellulose, the disintegrant is sodium carboxymethyl starch, and the lubricant is magnesium stearate.

[0066] (2) Preparation and pre-mixing of raw and auxiliary materials: take each component drug according to the weight of the formula ratio, first mix vitamin D3 and binder in equal amounts, and then add calcium carbonate, magnesium oxide, the remaining binder and disintegrant The solution is mixed.

[0067] (3) Granulation: Put the mixed materials into a wet granulator, add pur...

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PUM

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Abstract

The invention discloses a multi-vitamin element calcium preparation. The multi-vitamin element calcium preparation comprises calcium carbonate, vitamin D, magnesium oxide, copper sulfate and zinc sulfate; the weight ratio of vitamin D and calcium carbonate is 8*10<4>-9*10<4>; the weight ratio of vitamin D and magnesium oxide is 3.5*10<3>-3.8*10<3>; and the weight ratio of zinc sulfate and copper sulfate is 7-8.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a multidimensional element calcium preparation and a preparation method thereof. Background technique [0002] With the improvement of people's living standards and awareness of health care, as well as changes in people's eating habits and dietary structure, such as the intake of fat and refined sugar, insufficient intake of vegetables and fruits, and unbalanced diets, etc. Nutrient deficiency. [0003] Calcium is one of the most common elements in the human body. It is called "reinforced concrete in life". The content of calcium in the human body accounts for 1.5-2% of the total body weight, of which bones and teeth account for about 99%. Body fluids and soft tissues make up 1%. It plays a vital role in human metabolism, cell function, nervous system operation, and protein hormone synthesis. [0004] Necessary Calcium Intake Calcium is originally present in the 60 trillion cell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/34A61K9/28A61P3/02A61P19/10A23L33/155A23L33/16A61K33/10A61K31/59A61K33/08A61K33/30
CPCA23V2002/00A61K9/28A61K31/59A61K33/08A61K33/10A61K33/30A61K33/34A61K2300/00A23V2200/306
Inventor 胡炜
Owner SHANGHAI NUOCHENG PHARMA
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