Biomass-based nanoparticle as well as preparation method and application thereof

A nano- and biomass-based technology, applied in chemical instruments and methods, instruments, analytical materials, etc., can solve the problems of cumbersome processing, expensive instruments, and high cost of medicines, and achieve simple and easy-to-operate preparation processes, great application potential, detect sensitive effects

Active Publication Date: 2017-12-08
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used copper detection methods include atomic absorption spectrometry, ion chromatography, inductively coupled plasma mass spectrometry, etc. Although these methods are accurate and sensitive, they have disadvantages such as expensive instruments, cumbersome processing, long analysis time, and high drug costs.

Method used

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  • Biomass-based nanoparticle as well as preparation method and application thereof
  • Biomass-based nanoparticle as well as preparation method and application thereof
  • Biomass-based nanoparticle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A preparation method of biomass-based nanoparticles, the specific steps are as follows:

[0037] (1) Add 0.005 g of polycarboxylated cellulose nanocrystals (EOCN, carboxyl content 1 mmol / g) into 5 mL of water, ultrasonically disperse for 10 min, and then stir at room temperature until fully mixed to obtain a mixed solution;

[0038] (2) Pre-dissolve 0.02g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride / N-hydroxysuccinimide mixture (EDC / NHS, mass ratio 1:1) The catalyst solution was obtained in 5 mL of water, and then the catalyst solution was added dropwise to the mixed solution, and reacted at 18°C ​​for 60 minutes to obtain a reaction solution;

[0039] (3) Then add 0.0025g of 5-aminofluorescein to the reaction solution and react in the dark at 18°C ​​for 48 hours. After the reaction, centrifuge, pour off the supernatant, and pass the precipitated product through N,N-dimethylformamide, methanol After centrifuging and washing with acetone in turn, the pre...

Embodiment 2

[0043] A preparation method of biomass-based nanoparticles, the specific steps are as follows:

[0044] (1) Add 0.15 g of polycarboxylated cellulose nanocrystals (carboxyl content 0.1 mmol / g) into 15 mL of water, ultrasonically disperse for 15 min, and then stir at room temperature until fully mixed to obtain a mixed solution;

[0045] (2) Dissolve 0.03g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride / 4-dimethylaminopyridine mixture (EDC / DMAP, mass ratio 1:1) in advance The catalyst solution was obtained in 20mL of water, and then the catalyst solution was added dropwise to the uniformly dispersed mixed solution, and reacted at 25°C for 30 minutes to obtain a reaction solution;

[0046] (3) Then add 0.3g of 7-amino-4-methylcoumarin to the reaction solution and react in the dark at 25°C for 24 hours. After the reaction is completed, centrifuge, pour off the supernatant, and pass the precipitated product through N,N-Di After methylformamide and methanol were centrifu...

Embodiment 3

[0049] A preparation method of biomass-based nanoparticles, the specific steps are as follows:

[0050] (1) Add 0.2 g of polycarboxylated cellulose nanocrystals (carboxyl content 3 mmol / g) into 2 mL of N,N-dimethylformamide, ultrasonically disperse for 30 min, and then stir at room temperature until fully mixed to obtain a mixed solution;

[0051] (2) Dissolve 2g of 4-(4,6-dimethoxytriazin-2-yl)-4-methylmorpholine hydrochloride (DMTMM) in 40mL N,N-dimethylformamide Obtain a catalyst solution, then add the catalyst solution dropwise to the mixed solution, and react at 50°C for 10 minutes to obtain a reaction solution;

[0052] (3) Then add 2g of 7-amino-4-methylcoumarin to the reaction solution and react in the dark at 25°C for 24 hours. After the reaction, centrifuge, pour off the supernatant, and pass the precipitated product through N,N-dimethyl After centrifugation and washing with methyl formamide and methanol in sequence, the precipitated product was freeze-dried to obta...

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Abstract

The invention relates to a biomass-based nanoparticle for rapid ion detection and a preparation method thereof. The biomass-based nanoparticle is obtained by grafting a fluorescent molecule to carboxyl cellulose nanocrystal. The biomass-based nanoparticle can be directly used for copper ion concentration detection and analysis, pH of test solution and temperature do not need to be adjusted, rapid detection can be carried out on the spot, lower detection limit is 0.1ppm, whether drinking water for a human body and sewage discharged by a factory accord with the national standard or not can be directly detected, and the biomass-based nanoparticle has the advantages of sensitivity, no toxicity, environmental friendliness, good compatibility, low cost and simple technology compared with the traditional method.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a biomass-based nanoparticle and a preparation method and application thereof. Background technique [0002] Copper is one of the essential trace elements in the human body, and it plays an important role in the central nervous system, but excessive intake of copper ion concentration can lead to oxidative stress and many serious neurodegenerative diseases, such as Menkers syndrome, Amyotrophic lateral sclerosis, etc. As a non-biodegradable heavy metal, Cu 2+ It is easy to accumulate in the vital organs of humans and animals, and has a serious impact on organisms and the environment. my country has strict standards for the concentration of copper ions in human drinking water and industrial wastewater (Class I standard), which must not exceed 0.5 μg / mL, so the detection of copper ions is particularly important. Common copper detection methods include atomic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B11/20C09K11/06G01N21/64
CPCC08B11/20C09K11/06C09K2211/145G01N21/64G01N2021/6419
Inventor 黄进张燕洁夏涛陈瑶瑶
Owner WUHAN UNIV OF TECH
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