Totally biodegradable short fibre enhanced medical hydrogel body dressing and preparation method thereof

An all-biological, gel-based technology, applied in the medical field, can solve problems such as weak mechanical strength, and achieve the effects of low cost, improved mechanical properties, and low requirements for molding equipment

Inactive Publication Date: 2017-12-12
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gelatin and sodium alginate are often used as the matrix of gel dressings, but the mechanical strength of this matrix is ​​weak

Method used

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  • Totally biodegradable short fibre enhanced medical hydrogel body dressing and preparation method thereof
  • Totally biodegradable short fibre enhanced medical hydrogel body dressing and preparation method thereof
  • Totally biodegradable short fibre enhanced medical hydrogel body dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Weigh 1.2g of sodium alginate and 1.2g of hydroxymethyl cellulose, add 97.6g of deionized water, stir evenly for wet spinning, control the diameter to 10μm-50μm, and the aspect ratio to 1:2-1.

[0025] (2) Use a balance to weigh 1.90g of sodium alginate and add it to 150g of deionized water, stir it with a magnetic force at 30°C to dissolve completely, add 1.76g of sodium periodate solid, and react in the dark for 48 hours, and the temperature is not higher than 30°C, then add 0.41g Ethylene glycol was used to terminate the reaction, and 500 g of ethanol and 3.0 g of sodium chloride were added to allow static sedimentation, suction filtration, and drying in a vacuum oven at 40°C for 48 hours.

[0026] (3) Add 1.2g of sodium alginate, 1.2g of hydroxymethyl cellulose, and 2.4g of gelatin into 85g of deionized water, and stir magnetically at 50°C until completely dissolved.

[0027] (4) Weigh 1.2g of 1,2-propanediol and 4.8g of glycerol, add the system obtained in step...

Embodiment 2

[0030] (1) Weigh 0.2g of sodium alginate and 2.4g of hydroxymethyl cellulose, add 97.4g of deionized water, stir evenly for wet spinning, control the diameter to 10μm-50μm, and the aspect ratio to 1:2-1.

[0031] (2) Add 0.2g of sodium alginate, 2.4g of hydroxymethyl cellulose, and 1.2g of gelatin into 78.5g of deionized water, and stir magnetically at 30°C until completely dissolved.

[0032] (3) Weigh 3g of 1,2-propanediol and 9g of glycerol, add the system obtained in step (3), and stir to dissolve completely. Weigh 1.2g of partially oxidized sodium alginate prepared in step (2) of case 1, and stir magnetically at room temperature until the partially oxidized sodium alginate is completely dissolved and the system is free of stratification. Weigh and add 5.0 g of short fiber, the length is about 50 μm, and the aspect ratio is 1:1, stir magnetically at room temperature, and mix well.

[0033] (4) Take 50g of the above-mentioned homogeneous system and pour it into a petri dis...

Embodiment 3

[0035] (1) Weigh 0.6g of sodium alginate and 1.8g of hydroxymethyl cellulose, add 97.6g of deionized water, stir evenly and perform wet spinning, control the diameter to 10μm-50μm, and the aspect ratio to 1:2-1.

[0036] (2) Add 0.6g of sodium alginate, 1.8g of hydroxymethyl cellulose, and 1.8g of gelatin into 81.62g of deionized water, and stir magnetically at 40°C until completely dissolved.

[0037] (3) Weigh 1.75g ​​of 1,2-propanediol and 7.84g of glycerol, add the system obtained in step (3), and stir to dissolve completely. Weigh 0.6g of partially oxidized sodium alginate prepared in step (2) of case 1, and stir magnetically at room temperature until the partially oxidized sodium alginate is completely dissolved and the system is free of stratification. Weigh and add 1.0 g of short fiber, the length is about 20 μm, the aspect ratio is 2:1, magnetically stir at room temperature, and mix well.

[0038] (4) Take 50g of the above-mentioned homogeneous system and pour it int...

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Abstract

The invention relates to a totally biodegradable short fibre enhanced medical hydrogel body dressing and a preparation method thereof. A hydrogel system is enhanced by adopting short fibres; a substrate is formed by blending partially oxidized sodium alginate/sodium alginate/gelatine/hydroxymethyl cellulose solution; and the short fibres are prepared from the sodium alginate and hydroxymethyl cellulose by wet spinning. The hydrogel obtained by the preparation has outstanding mechanical performance, excellent toughness and high water resistance, and is biodegradable; raw materials are easily obtained; a process flow is simple; and conditions are mild. The mechanical performance can be controlled by regulating the concentration of calcium ions and the content of the enhancing short fibres.

Description

technical field [0001] The invention relates to a preparation method of a hydrogel dressing reinforced by degradable short fibers for medical use, and particularly relates to a fully biodegradable medical hydrogel reinforced by sodium alginate---hydroxymethylcellulose short fibers A preparation method of a dressing belongs to the technical field of medicine. Background technique [0002] Medical polymer hydrogel wound dressing is a new type of dressing developed in recent years. Compared with traditional gauze dressings, it has significant advantages, such as: it can keep the wound moist for a long time, has strong coverage, is degradable, has excellent biocompatibility, and is non-toxic. Adhesion with the skin, etc. But at the same time, there are shortcomings that need to be overcome urgently, such as: the strength of the material is low, and the water resistance is not good. [0003] Sodium alginate is a polysaccharide extracted from brown algae and is one of the natura...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J7/06C08J3/075C08J3/24
CPCA61L26/0004A61L26/0052A61L26/0061A61L26/008C08J3/075C08J3/246C08J7/06C08J2301/28C08J2389/00C08J2401/28C08J2405/04C08L5/04C08L1/28C08L89/00
Inventor 马贵平李禄禄聂俊高易李哲夫
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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