A kind of chitosan-based composite nerve guide and its preparation method and application
A nerve conduit, chitosan technology, applied in prosthesis, tissue regeneration, medical science and other directions, can solve problems such as unfavorable nerve growth and repair, unfavorable nerve growth, etc. good support effect
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Embodiment 1
[0022] Embodiment 1: Preparation of acylated chitosan tube: take by weighing 2 g of acylated chitosan powder (90.5% acetyl group molar percentage), add 100 ml of 80% formic acid solution, stir and dissolve, and prepare a mass volume ratio of 2% acylated chitosan glue. Make a hollow acylated chitosan tube with a wall thickness of 0.5 mm and a diameter of 4 mm on a tube making machine, place the dry acylated chitosan tube in 2% NaOH aqueous solution for acid-base neutralization, wash with water until the pH is neutral, Dry to produce acylated chitosan tubes.
[0023] In the preparation of the acylated chitosan tube, the same effect can be achieved by using the following acylated chitosan, the acylated chitosan can be acetyl chitosan, propionyl chitosan, butyryl shell Polysaccharide, hexanoyl chitosan, octanoyl chitosan, caproyl chitosan, lauroyl chitosan, palmitoyl chitosan and other aliphatic or aromatic acyl chitosan or one or more Mixtures, or acylated shells containing one...
Embodiment 2
[0026] Embodiment 2: Preparation 1 of chitosan-based composite nerve guide
[0027]Weigh 2 g of acetylated chitosan powder (90.5% molar content of acyl groups), add 100 ml of 80% formic acid solution as a solvent, stir and dissolve, and prepare an acylated chitosan glue solution with a concentration of 2% by mass. Make a hollow acylated chitosan tube with a wall thickness of 0.05 mm, a lumen diameter of 2 mm, and a length of 10 cm on a tube making machine, dry it naturally, and place the dried acylated chitosan tube in 2% NaOH aqueous solution for acid-base Neutralize, wash with water until the pH is neutral, and dry to prepare the acylated chitosan tube 1.
[0028] The polysaccharide fiber calcium alginate fiber loaded with calcium is taken, and the calcium alginate fiber is loosely filled in the acylated chitosan tube 1 along the direction, and the chitosan-based composite nerve guide 1 is prepared.
Embodiment 3
[0029] Embodiment 3: Preparation 2 of chitosan-based composite nerve guide
[0030] Weigh 5 g of butyrylated chitosan powder (125.2% molar content of acyl groups), add 100 ml of acetone solution as a solvent, stir and dissolve, and prepare an acylated chitosan glue solution with a concentration of 5% by mass. A hollow acylated chitosan tube with a wall thickness of 0.5 mm, a lumen diameter of 4 mm, and a length of 10 cm was made on a tube making machine, and heated and dried at 50° C. to obtain an acylated chitosan tube 2 .
[0031] The calcium-loaded polysaccharide fiber carboxymethyl cellulose calcium fiber is taken, and the carboxymethyl cellulose calcium fiber is loosely filled in the acylated chitosan tube 2 along the direction to prepare the chitosan-based composite nerve guide 2 .
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