A kind of chitosan-based composite nerve guide and its preparation method and application

Abstract

The invention discloses a chitosan-based composite nerve conduit as well as a preparation method and an application thereof. The chitosan-based composite nerve conduit is formed by compositing an acrylated chitosan conduit wall and internal filler of calcium-supported polysaccharide fiber. Acrylated chitosan is one of or a mixture of more of aliphatic or aromatic acrylated chitosans, and the mole percentage of acryl groups is larger than 0 and smaller than 300%; the calcium-supported polysaccharide fiber is calcium carboxylate, calcium sulfonate or calcium succinate supported polysaccharide fiber. The chitosan-based composite nerve conduit is used as a nerve conduit or a nerve bridging conduit for defective nerve repair. The degradation time of the acrylated chitosan conduit wall is longer than that of the chitosan conduit wall, the support effect of the nerve conduit is enhanced and prolonged, meanwhile, degradation inflammation reactions are slight, and the in-vivo biological tissue compatibility is good; the calcium-supported polysaccharide fiber is beneficial to guide of growth of nerve fiber and a good growth environment is provided.

Description

technical field

[0001] The invention relates to a nerve repair medical material, in particular to a chitosan-based composite nerve guide and its preparation method and application, belonging to the field of biomedical materials. Background technique

[0002] Peripheral nerve defects caused by mechanical trauma, traffic accidents, etc. are one of the common traumatic manifestations. After nerve injury, the distal limbs dominated by the affected nerves suffer from loss of sensory and motor functions, resulting in physical disabilities and serious quality of life for patients. decline. The defect of a small segment of nerve can be restored by the self-repair ability of the nerve, while the repair of a long segment of defective nerve cannot be repaired by itself. It needs to be modified by surgical autologous nerve transplantation or implantation of nerve bridges to guide the growth of the proximal regenerated nerve. . Nerve conduits are a hotspot in the research of nerve brid...

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