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Polyurethane porous thin film containing grapheme as well as preparation method and application thereof

A porous film and graphene technology, applied in medical science, prosthesis, etc., can solve the problems of increased risk of wound infection, limited drainage capacity, and can not be used for a long time, to prevent external bacterial infection, easy to control performance, good air permeability Effect

Inactive Publication Date: 2017-12-19
重庆石墨烯研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this artificial skin also has disadvantages in clinical use: it cannot be used for a long time, and its mechanical strength is poor. In the later stage of treatment, the upper layer of silicone rubber must be removed, which is prone to infection and additionally increases the pain of patients; the upper layer of silicone rubber film is a dense film. , limited drainage, accumulation of exudate, and the need for frequent replacements, leading to an increased risk of wound infection
And the price is expensive, the cost is higher

Method used

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  • Polyurethane porous thin film containing grapheme as well as preparation method and application thereof
  • Polyurethane porous thin film containing grapheme as well as preparation method and application thereof
  • Polyurethane porous thin film containing grapheme as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Dissolve three parts of 25g medical grade polyurethane in 150mL of N,N-dimethylformamide at 60℃, and then add 50mL of graphite oxide to the concentration of 0.25mg / mL, 0.5mg / mL, 2.5mg / mL respectively. The alkene solution was stirred for 2 hours, 60 g of sodium citrate with a particle size of 75-150 μm was added, and the mixture was mechanically stirred for 1 hour. Degas the above solution at room temperature and a vacuum of 0.06 MPa for 20 minutes. Pour the defoamed suspension evenly into a polytetrafluoroethylene mold with a coating film thickness of 2 mm, and then put it in anhydrous ethanol at 25° C. for phase separation and solidify into a film. The cured porous membrane is washed in deionized water at 25°C, and the porogen is fully filtered out. The porous membrane from which the porogen is filtered out is placed in a blast oven at 40°C for drying to obtain a graphene-containing polyurethane porous membrane.

[0041] Structural characterization and performance testi...

Embodiment 2

[0055] Dissolve 25g of medical grade polyurethane in 150mL of N,N-dimethylformamide at 60°C, then add 50mL of 0.5mg / mL graphene oxide solution and stir for more than 2h. Degas the above solution at room temperature and a vacuum of 0.06 MPa for 20 minutes. Pour the degassed solution evenly into a polytetrafluoroethylene mold with a coating film thickness of 1 mm, and then put it in anhydrous ethanol at 25°C for phase separation and solidify into a film. The cured polyurethane porous membrane was washed in deionized water at 25°C. The porous film was dried in a 40°C blast oven to obtain a graphene-containing polyurethane porous film.

Embodiment 3

[0057] Dissolve three parts of 25g medical grade polyurethane in 150mL N,N-dimethylformamide at 60℃, and then add 50mL graphene oxide solution with concentration of 5mg / mL, 10mg / mL and 25mg / mL respectively. Stir for 2h, add 60g of sodium citrate with a particle size of 75-150μm, and mechanically stir for 1h. Degas the above solution at room temperature and a vacuum of 0.06 MPa for 20 minutes. Pour the defoamed suspension evenly into a polytetrafluoroethylene mold with a coating film thickness of 2 mm, and then put it in anhydrous ethanol at 25° C. for phase separation and solidify into a film. The cured porous membrane is washed in deionized water at 25°C, and the porogen is fully filtered out. The porous membrane from which the porogen is filtered out is placed in a blast oven at 40°C for drying to obtain a graphene-containing polyurethane porous membrane.

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Abstract

The invention discloses a polyurethane porous thin film containing grapheme as well as a preparation method and application thereof. The preparation method comprises the following steps: adding polyurethane into a solvent for dissolution, adding a grapheme solution, adding a pore-foaming agent and obtaining a suspension after mechanical stirring for a certain time; performing vacuum de-foaming on the suspension, casting into a film on a mold, curing into a film in an anhydrous ethanol coagulation bath and then putting in deionized water for soaking, so that the pore-foaming agent is dissolved and completely removed; taking out a thin film and putting in an air blast baking oven for drying to obtain the polyurethane porous thin film containing the grapheme. The film can be used for artificial skin and has the advantages of being good in water and gas permeability, high in water absorption rate, excellent in mechanical property, good in biological affinity and the like.

Description

Technical field [0001] The invention relates to a graphene-containing polyurethane porous film, a preparation method and application thereof, and belongs to the technical field of bioengineering materials. Background technique [0002] The skin is the largest organ of the human body and a natural barrier to protect the body. For patients with severe skin defects, a large amount of body fluid loss and wound infection are the main factors that threaten the lives of patients. It is particularly important to prepare an artificial skin with certain strength, toughness, and waterproof and breathable performance close to real skin, which can alleviate patients' pain and save patients' lives. [0003] Medical polyurethane has excellent mechanical properties and excellent water resistance. At the same time, it has good biocompatibility, blood compatibility, tissue compatibility, anticoagulation, non-toxicity, and non-teratogenic effects. In addition, polyurethane has greater freedom of mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26C08L75/04C08K3/04A61L27/18A61L27/08A61L27/50A61L27/56A61L27/60
CPCA61L27/08A61L27/18A61L27/50A61L27/56A61L27/60C08J9/26C08J2201/0422C08J2375/04C08K3/04C08K2201/011C08L75/04
Inventor 夏和生罗高兴蒋瑶珮杨涛王颖
Owner 重庆石墨烯研究院有限公司
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