Momordica charantia polypeptide pharmaceutical composition for treating diabetes ulcer and preparation method thereof

A technology for diabetic ulcers and bitter gourd polypeptides, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems such as the inability to guarantee the stability and significance of product efficacy, the lack of quality controllability and content of key ingredients of raw materials, etc. Recover islet cell function, improve human immunity, and have a significant effect

Inactive Publication Date: 2017-12-26
李玉保 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although it has been recognized that balsam pear is a plant raw material with hypoglycemic effect, and it is used in the treatment of diabetes and its complications, there are some problems: one is the above-mentioned literature and other related medicines for the treatment of diabetic ulcers, Most of the various formula raw materials are directly crushed, without the quality controllability and content of the key components of the raw materials and the preparation process, and the stability and significance of the product efficacy cannot be guaranteed; ingredients

Method used

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  • Momordica charantia polypeptide pharmaceutical composition for treating diabetes ulcer and preparation method thereof
  • Momordica charantia polypeptide pharmaceutical composition for treating diabetes ulcer and preparation method thereof
  • Momordica charantia polypeptide pharmaceutical composition for treating diabetes ulcer and preparation method thereof

Examples

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Effect test

Embodiment 1

[0060] Embodiment 1 provides a kind of bitter gourd polypeptide pharmaceutical composition for treating diabetic ulcer, and its specific steps are as follows:

[0061]Preparation of bitter gourd polypeptide extract: choose fresh bitter gourd with long growth period, greenish yellowish color and plump bitter gourd seeds as raw material, first wash the raw material of bitter gourd with tap water, and then wash with electrolytic high-concentration ozone water, the ozone concentration in the cleaning water is 15mg / L, water flow 300L / h, to reduce pesticide residues and microbial residues. Beat and crush the cleaned bitter gourd raw material into a liquid material passing through a 20-mesh screen; pour the beaten and crushed bitter gourd raw material into an ultrasonic assisted extraction tank, add 8 times the mass of purified water at 50°C, and use buffer salt to adjust the system pH=7, ultrasonic-assisted countercurrent extraction was carried out 3 times, 30 minutes each time. U...

Embodiment 2

[0064] Embodiment 2 provides a kind of bitter melon polypeptide pharmaceutical composition for the treatment of diabetic ulcers, and its specific steps are as follows:

[0065] Preparation of balsam pear polypeptide protein extract: select fresh balsam pear with long growth period, greenish yellowish color and plump balsam pear seeds as raw material, wash the balsam pear raw material with tap water first, and then wash with electrolytic high-concentration ozone water, the ozone concentration in water is 20mg / L, the water flow rate is 450L / h to reduce pesticide residues and microbial residues. Beating and crushing the washed bitter gourd raw material into a liquid material passing through a 20-mesh sieve. Pour the beaten and crushed bitter gourd raw materials into an ultrasonic-assisted extraction tank, add 5 times the mass of purified water at 38°C, use buffer salt to adjust the pH of the system to 6.7, and perform ultrasonic-assisted countercurrent extraction twice, each tim...

Embodiment 3

[0068] Embodiment 3 provides a kind of bitter gourd polypeptide pharmaceutical composition for treating diabetic ulcer, and its specific steps are as follows:

[0069] Preparation of bitter gourd polypeptide protein extract: select dried bitter gourd or sliced ​​bitter gourd with greenish yellowish color and plump flesh as raw material, and crush the raw material of bitter gourd into coarse powder passing through a 20-mesh sieve. Pour the pulverized bitter melon raw material into an ultrasonic-assisted extraction tank, add 10 times the mass of purified water at 52°C, use buffer salt to adjust the pH of the system to 6.8, and conduct ultrasonic-assisted countercurrent extraction twice, each time for 45 minutes. Use a high-speed tubular centrifuge for centrifugation, and remove the slag to obtain a centrate. The centrifugate was filtered through a ceramic microfiltration membrane system with a molecular weight cut-off of 0.2 μm, the operating temperature was 35° C., and the pres...

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Abstract

The invention provides a momordica charantia polypeptide pharmaceutical composition for treating diabetes ulcer and a preparation method thereof, belonging to the technical field of diabetes drugs. The momordica charantia polypeptide pharmaceutical composition for treating the diabetes ulcer is prepared from the following raw materials in parts by weight: 3 to 5 parts of momordica charantia polypeptide extract, 2 to 4 parts of grape seed extract, 2 to 4 parts of galla chinensis extract, 2 to 4 parts of radix puerariae extract and 0.08 to 0.2 part of vitamin C; the content of momordica charantia polypeptide protein in the momordica charantia polypeptide extract is 20% or above; the content of procyanidine in the grape seed extract is 60% or above; the content of tannin in the galla chinensis extract is 80% or above; the content of radix puerariae total flavonoid in the radix puerariae extract is 60% or above. The invention further provides the preparation method of the momordica charantia polypeptide pharmaceutical composition for treating the diabetes ulcer. The momordica charantia polypeptide pharmaceutical composition for treating the diabetes ulcer provided by the invention is a pure plant preparation, and can be used for effectively relieving and treating the diabetes concurrent ulcer.

Description

technical field [0001] The invention relates to the technical field of medicines for diabetes and its complications, in particular to a bitter melon polypeptide pharmaceutical composition for treating diabetic ulcers and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards and the rapid development of the social economy, the number of diabetic patients in my country has shown a rapid growth trend. At present, the incidence of diabetes in my country is as high as 9.6%, and the number of diabetic patients has exceeded 110 million, and the number of patients is still increasing year by year. Diabetes is called diabetes in ancient times, and it refers to a syndrome characterized by polydipsia, polyuria, polyphagia, weight loss, fatigue, and sweet urine. Diabetes is a disease characterized by polydipsia, polyphagia, polyuria, and emaciation due to deficiency of yin, dryness and heat, and deficiency of five viscer...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K36/42A61K36/87A61K9/48A61K9/06A61K9/14A61P3/10A61P17/02A61K31/375A61K35/64A61K35/644
CPCA61K9/0014A61K9/06A61K9/146A61K9/4866A61K31/375A61K35/63A61K35/644A61K36/42A61K36/488A61K36/54A61K36/57A61K36/87A61K38/011A61K47/36A61K2236/31A61K2236/51A61K2236/53A61K2300/00
Inventor 何静仁李玉保
Owner 李玉保
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